Clonal anergy in self-reactive α/β T cells is abrogated by heat-shock protein-reactive γ/δ T cells in aged athymic nude mice

1990 ◽  
Vol 20 (7) ◽  
pp. 1475-1482 ◽  
Author(s):  
Hiroyuki Yuuki ◽  
Yasunobu Yoshikai ◽  
Kenji Kishihara ◽  
Akinori Iwasaki ◽  
Goto Matsuzaki ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Nude Mice ◽  
Athymic Nude Mice ◽  
Clonal Anergy

scholarly journals Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease

2017 ◽  
Vol 85 (8) ◽  
Author(s):  
Lucia Trotta ◽  
Kathleen Weigt ◽  
Katina Schinnerling ◽  
Anika Geelhaar-Karsch ◽  
Gerrit Oelkers ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
T Cell Responses ◽  
Tropheryma Whipplei ◽  
Content Type ◽  
Cell Responses ◽  
Ifn Γ

ABSTRACT Classical Whipple's disease (CWD) is characterized by the lack of specific Th1 response toward Tropheryma whipplei in genetically predisposed individuals. The cofactor GrpE of heat shock protein 70 (Hsp70) from T. whipplei was previously identified as a B-cell antigen. We tested the capacity of Hsp70 and GrpE to elicit specific proinflammatory T-cell responses. Peripheral mononuclear cells from CWD patients and healthy donors were stimulated with T. whipplei lysate or recombinant GrpE or Hsp70 before levels of CD40L, CD69, perforin, granzyme B, CD107a, and gamma interferon (IFN-γ) were determined in T cells by flow cytometry. Upon stimulation with total bacterial lysate or recombinant GrpE or Hsp70 of T. whipplei, the proportions of activated effector CD4+ T cells, determined as CD40L+ IFN-γ+, were significantly lower in patients with CWD than in healthy controls; CD8+ T cells of untreated CWD patients revealed an enhanced activation toward unspecific stimulation and T. whipplei-specific degranulation, although CD69+ IFN-γ+ CD8+ T cells were reduced upon stimulation with T. whipplei lysate and recombinant T. whipplei-derived proteins. Hsp70 and its cofactor GrpE are immunogenic in healthy individuals, eliciting effective responses against T. whipplei to control bacterial spreading. The lack of specific T-cell responses against these T. whipplei-derived proteins may contribute to the pathogenesis of CWD.

Synovial fluid-derivedYersinia-reactive T cells responding to human 65-kDa heat-shock protein and heat-stressed antigen-presenting cells

1991 ◽  
Vol 21 (9) ◽  
pp. 2139-2143 ◽  
Author(s):  
Elisabeth Hermann ◽  
Ansgar W. Lohse ◽  
Ruurd Van Der Zee ◽  
Willem Van Eden ◽  
Werner J. Mayet ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Synovial Fluid ◽  
Heat Shock Protein ◽  
Antigen Presenting Cells ◽  
Antigen Presenting

scholarly journals T Cells Recognize an Immunodominant Epitope of Heat Shock Protein 65 in Kawasaki Disease

2000 ◽  
Vol 6 (7) ◽  
pp. 581-590 ◽  
Author(s):  
Guido Sireci ◽  
Francesco Dieli ◽  
Alfredo Salerno
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Kawasaki Disease ◽  
Heat Shock Protein ◽  
Immunodominant Epitope ◽  
Heat Shock Protein 65

Stress-induced facilitation of host response to bacterial challenge in F344 rats is dependent on extracellular heat shock protein 72 and independent of alpha beta T cells

Stress ◽  
2012 ◽  
Vol 15 (6) ◽  
pp. 637-646 ◽  
Author(s):  
Jay Campisi ◽  
Craig Sharkey ◽  
John D. Johnson ◽  
Alexzander Asea ◽  
Thomas Maslanik ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Host Response ◽  
Bacterial Challenge ◽  
Heat Shock Protein 72 ◽  
Alpha Beta ◽  
F344 Rats

scholarly journals Scant activation of CD8 T?cells by antigen loaded on heat shock protein

2005 ◽  
Vol 35 (4) ◽  
pp. 1046-1055 ◽  
Author(s):  
Florian Winau ◽  
Anne-Marit Sponaas ◽  
Stephan Weber ◽  
Vera Schwierzeck ◽  
Ralf Winter ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cd8 T Cells

Heat shock protein 70 (Hsp70) interacts with the Notch1 intracellular domain and contributes to the activity of Notch signaling in myelin-reactive CD4 T cells

2015 ◽  
Vol 287 ◽  
pp. 19-26 ◽  
Author(s):  
Maciej Juryńczyk ◽  
Przemysław Lewkowicz ◽  
Małgorzata Domowicz ◽  
Marcin P. Mycko ◽  
Krzysztof W. Selmaj
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Notch Signaling ◽  
Cd4 T Cells ◽  
Heat Shock Protein 70 ◽  
Intracellular Domain

scholarly journals Prevention of autoimmune lysis by T cells with specificity for a heat shock protein by antisense oligonucleotide treatment.

1994 ◽  
Vol 91 (11) ◽  
pp. 5085-5088 ◽  
Author(s):  
U. Steinhoff ◽  
U. Zugel ◽  
A. Wand-Wurttenberger ◽  
H. Hengel ◽  
R. Rosch ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Antisense Oligonucleotide
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