scholarly journals Scant activation of CD8 T?cells by antigen loaded on heat shock protein

2005 ◽  
Vol 35 (4) ◽  
pp. 1046-1055 ◽  
Author(s):  
Florian Winau ◽  
Anne-Marit Sponaas ◽  
Stephan Weber ◽  
Vera Schwierzeck ◽  
Ralf Winter ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cd8 T Cells

scholarly journals The Adjuvant Effects of Mycobacterium tuberculosis Heat Shock Protein 70 Result from the Rapid and Prolonged Activation of Antigen-Specific CD8+ T Cells In Vivo

2002 ◽  
Vol 169 (10) ◽  
pp. 5622-5629 ◽  
Author(s):  
Lisa A. E. Harmala ◽  
Elizabeth G. Ingulli ◽  
Julie M. Curtsinger ◽  
Michelle M. Lucido ◽  
Clint S. Schmidt ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cd8 T Cells ◽  
Heat Shock Protein 70 ◽  
Adjuvant Effects

scholarly journals Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin Enhances EphA2+ Tumor Cell Recognition by Specific CD8+ T Cells

2009 ◽  
Vol 69 (17) ◽  
pp. 6995-7003 ◽  
Author(s):  
Mayumi Kawabe ◽  
Maja Mandic ◽  
Jennifer L. Taylor ◽  
Cecilia A. Vasquez ◽  
Amy K. Wesa ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Cell ◽  
Cd8 T Cells ◽  
Heat Shock Protein 90 ◽  
Cell Recognition

scholarly journals HspA1B Is a Prognostic Biomarker and Correlated With Immune Infiltrates in different subtypes of Breast Cancers

2019 ◽  
Author(s):  
Jian He ◽  
Hui Wang
Keyword(s):  
Breast Cancer ◽  
Gastric Cancer ◽  
T Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cancer Patients ◽  
Cd8 T Cells ◽  
Prognostic Biomarker ◽  
Clinical Prognosis ◽  
Free Survival

ABSTRACTBackgroundHeat shock A1B, also known as HSP70kDa protein 1B, encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. HspA1B is a critical gene which related to many type of diseases by involving in the ubiquitin-proteasome pathway. However, the correlations of HspA1B to prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear.MethodsHspA1B expression was evaluated on the Oncomine database and Tumor Immune Estimation Resource (TIMER) site. We analyzed the influence of HspA1B on clinical prognosis using Kaplan-Meier plotter, the PrognoScan database and Gene Expression Profiling Interactive Analysis (GEPIA). The correlations between HspA1B and cancer immune infiltrates was investigated via TIMER. In addition, correlations between HspA1B expression and gene marker sets of immune infiltrates were analyzed by TIMER and GEPIA.ResultsThree cohorts (GSE9195, GSE9893, GSE3494-GPL96)) of breast cancer patients showed that high HspA1B expression was associated with poorer overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). In addition, high HspA1B expression was significantly correlated with poor OS and progression-free survival (PFS) in bladder cancer, brain cancer and skin cancer. Moreover, HspA1B significantly impacts the prognosis of diverse cancers via The Cancer Genome Atlas (TCGA). HspA1B expression was positively correlated with infiltrating levels of CD4+ T and CD8+ T cells, macrophages, neutrophils, and dendritic cells (DCs) indifferent subtypes of Breast cancer. HspA1B expression showed strong correlations with diverse immune marker sets in BRCA-Luminal.ConclusionsOur findings suggest that HspA1B is correlated with prognosis and immune infiltrating levels of, including those of CD8+ T cells, CD4+ T cells, macrophages, neutrophils, and DCs in multiple cancers, especially in colon and gastric cancer patients. In addition, HspA1B expression potentially contributes to regulation of tumor-associated macrophages (TAMs), DCs, T cell exhaustion and Tregs in colon and gastric cancer. These findings suggest that HspA1B can be used as a prognostic biomarker for determining prognosis and immune infiltration in BRCA-Luminal subtype.

scholarly journals Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease

2017 ◽  
Vol 85 (8) ◽  
Author(s):  
Lucia Trotta ◽  
Kathleen Weigt ◽  
Katina Schinnerling ◽  
Anika Geelhaar-Karsch ◽  
Gerrit Oelkers ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
T Cell Responses ◽  
Tropheryma Whipplei ◽  
Content Type ◽  
Cell Responses ◽  
Ifn Γ

ABSTRACT Classical Whipple's disease (CWD) is characterized by the lack of specific Th1 response toward Tropheryma whipplei in genetically predisposed individuals. The cofactor GrpE of heat shock protein 70 (Hsp70) from T. whipplei was previously identified as a B-cell antigen. We tested the capacity of Hsp70 and GrpE to elicit specific proinflammatory T-cell responses. Peripheral mononuclear cells from CWD patients and healthy donors were stimulated with T. whipplei lysate or recombinant GrpE or Hsp70 before levels of CD40L, CD69, perforin, granzyme B, CD107a, and gamma interferon (IFN-γ) were determined in T cells by flow cytometry. Upon stimulation with total bacterial lysate or recombinant GrpE or Hsp70 of T. whipplei, the proportions of activated effector CD4+ T cells, determined as CD40L+ IFN-γ+, were significantly lower in patients with CWD than in healthy controls; CD8+ T cells of untreated CWD patients revealed an enhanced activation toward unspecific stimulation and T. whipplei-specific degranulation, although CD69+ IFN-γ+ CD8+ T cells were reduced upon stimulation with T. whipplei lysate and recombinant T. whipplei-derived proteins. Hsp70 and its cofactor GrpE are immunogenic in healthy individuals, eliciting effective responses against T. whipplei to control bacterial spreading. The lack of specific T-cell responses against these T. whipplei-derived proteins may contribute to the pathogenesis of CWD.

Synovial fluid-derivedYersinia-reactive T cells responding to human 65-kDa heat-shock protein and heat-stressed antigen-presenting cells

1991 ◽  
Vol 21 (9) ◽  
pp. 2139-2143 ◽  
Author(s):  
Elisabeth Hermann ◽  
Ansgar W. Lohse ◽  
Ruurd Van Der Zee ◽  
Willem Van Eden ◽  
Werner J. Mayet ◽  
...  
Keyword(s):  
T Cells ◽  
Heat Shock ◽  
Synovial Fluid ◽  
Heat Shock Protein ◽  
Antigen Presenting Cells ◽  
Antigen Presenting
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