scholarly journals Rationale for and design of the TRUE-AHF trial: the effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure

2016 ◽  
Vol 19 (5) ◽  
pp. 673-681 ◽  
Author(s):  
Milton Packer ◽  
Richard Holcomb ◽  
William T. Abraham ◽  
Stefan Anker ◽  
Kenneth Dickstein ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Clinical Course ◽  
Short Term ◽  
Long Term Mortality

scholarly journals Evaluation of Thyroid Function in Patients Hospitalized for Acute Heart Failure

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Ana Rita Leite ◽  
João Sérgio Neves ◽  
Marta Borges-Canha ◽  
Catarina Vale ◽  
Madalena von Hafe ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Clinical Outcomes ◽  
Acute Heart Failure ◽  
Thyroid Function ◽  
Short Term ◽  
Cardiovascular Parameters ◽  
Adjusted Model ◽  
Long Term Mortality

Background. Thyroid hormones (TH) are crucial for cardiovascular homeostasis. Recent evidence suggests that acute cardiovascular conditions, particularly acute heart failure (AHF), significantly impair the thyroid axis. Our aim was to evaluate the association of thyroid function with cardiovascular parameters and short- and long-term clinical outcomes in AHF patients. Methods. We performed a single-centre retrospective cohort study including patients hospitalized for AHF between January 2012 and December 2017. We used linear, logistic, and Cox proportional hazard regression models to analyse the association of thyroid-stimulating hormone (TSH) and free thyroxine (FT4) with inpatient cardiovascular parameters, in-hospital mortality, short-term adverse clinical outcomes, and long-term mortality. Two models were used: (1) unadjusted, and (2) adjusted for age and sex. Results. Of the 235 patients included, 59% were female, and the mean age was 77.5 (SD 10.4) years. In the adjusted model, diastolic blood pressure was positively associated with TSH [β = 2.68 (0.27 to 5.09); p = 0.030 ]; left ventricle ejection fraction (LVEF) was negatively associated with FT4 [β = -24.85 (-47.87 to -1.82); p = 0.035 ]; and a nonsignificant trend for a positive association was found between 30-day all-cause mortality and FT4 [OR = 3.40 (0.90 to 12.83); p = 0.071 ]. Among euthyroid participants, higher FT4 levels were significantly associated with a higher odds of 30-day all-cause death [OR = 4.40 (1.06 to 18.16); p = 0.041 ]. Neither TSH nor FT4 levels were relevant predictors of long-term mortality in the adjusted model. Conclusions. Thyroid function in AHF patients is associated with blood pressure and LVEF during hospitalization. FT4 might be useful as a biomarker of short-term adverse outcomes in these patients.

scholarly journals Impact of diabetes mellitus on mortality in patients with acute heart failure: a prospective cohort study

2020 ◽  
Author(s):  
Min Gyu Kong ◽  
Se Yong Jang ◽  
Jieun Jang ◽  
Hyun-Jai Cho ◽  
Sangjun Lee ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Glycemic Control ◽  
Ejection Fraction ◽  
Acute Heart Failure ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Inadequate Glycemic Control ◽  
Long Term Mortality

Abstract Background Although more than one third of the patients with acute heart failure (AHF) have diabetes mellitus (DM), it is unclear whether DM exerts adverse impact on clinical outcomes. This study aimed to compare the outcomes in patients hospitalized for AHF in accordance with DM and left ventricular ejection fraction (LVEF). Methods The Korean Acute Heart Failure registry prospectively enrolled and completed follow-up of 5,625 patients from March 2011 to February 2019. Primary endpoints were in-hospital and overall all-cause mortality. We evaluated the impact of DM on these mortalities according to HF subtypes and glycemic control. Results DM was significantly associated with increased long-term mortality (adjusted hazard ratio [HR], 1.12; 95% confidence interval [CI], 1.02-1.22) even after adjusting for potential confounders. In subgroup analysis according to LVEF, DM was associated with higher long-term mortality in only HF with reduced ejection fraction (HFrEF) (adjusted HR, 1.14; 95% CI, 1.02-1.27). Inadequate glycemic control defined by HbA1c ≥ 7.0% within 1 year after discharge was significantly associated with higher long-term mortality compared to adequate glycemic control (HbA1c <7.0%) (44.0% vs. 36.8%; Log-rank p =0.016). Conclusions This large registry data showed that DM and inadequate glycemic control were significantly associated with increased long-term mortality in AHF, especially HFrEF. Tight glucose control is required to mitigate long-term mortality.

Hypoalbuminemia in Acute Heart Failure Patients: Causes and Its Impact on Hospital and Long-Term Mortality

2014 ◽  
Vol 20 (5) ◽  
pp. 350-358 ◽  
Author(s):  
Juan Luis Bonilla-Palomas ◽  
Antonio Luis Gámez-López ◽  
Mirian Moreno-Conde ◽  
María Cristina López-Ibáñez ◽  
Manuel Anguita-Sánchez ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Heart Failure Patients ◽  
Long Term Mortality

scholarly journals Effect of precipitating factors of acute heart failure on readmission and long‐term mortality

2016 ◽  
Vol 3 (2) ◽  
pp. 115-121 ◽  
Author(s):  
Mattia Arrigo ◽  
Heli Tolppanen ◽  
Malha Sadoune ◽  
Elodie Feliot ◽  
Antonio Teixeira ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Precipitating Factors ◽  
Long Term Mortality

A simple parameter for long-term mortality in acute heart failure patients: serum albumin

2019 ◽  
pp. 1-1
Author(s):  
Tufan Çınar ◽  
Mert İlker Hayıroğlu ◽  
Vedat Çiçek ◽  
Ahmet Lütfullah Orhan
Keyword(s):  
Heart Failure ◽  
Serum Albumin ◽  
Acute Heart Failure ◽  
Heart Failure Patients ◽  
Simple Parameter ◽  
Long Term Mortality

Abstract 18183: Short-term Impact of Defibrillation Testing on Heart Failure Admission

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Baris Akdemir ◽  
Balaji Krishnan ◽  
Venkatakrishna Tholakanahalli ◽  
David Benditt ◽  
Jian-Ming Li
Keyword(s):  
Heart Failure ◽  
Retrospective Study ◽  
Short Term ◽  
Primary Endpoints ◽  
Significant Difference ◽  
Heart Failure Admission ◽  
The Mean ◽  
Demographic Features ◽  
Long Term Mortality

Introduction: SIMPLE trial showed that defibrillation testing (DT) is safe but does not improve shock efficacy or mortality. However, impact of DT on heart failure (HF) admission at 30 days is unclear. Objectives: The aim of this study was to compare mortality and HF admission of ICD recipients who underwent DT (DT+) compared with those who did not (DT-). Methods: In this retrospective study, we analyzed consecutive patients who received an ICD ( new implant or generator change ) with DT+ and DT- between January 2008 and May 2014 from our ICD registry. Primary endpoints were death ( 30 days and 1 year ) and HF admission ( 30 days) . Results: Of the 501 patients, 311 patients (62,1%) were in DT+ group vs 190 (37,9%) were in DT- group. The mean ages in DT+ and DT- were 66 ± 10 and 70 ± 10 respectively (p<0.0001). DT- group had more generator change than DT+ group ( 61,1% versus 30,9%, p < 0.0001). Other demographic features were not significantly different between two groups (Table 1). No significant difference in mortality was found between two groups at 30 days and 1 year. HF admission at 30 days was significantly higher in DT+ group than in DT- group ( 17,4 % versus 4,7%, p < 0.0001) (Table 2). Conclusion: No short-term and long-term mortality were associated with DT, but DT was associated with increased HF admission at 30 days. Future prospective studies are needed to prove this association.

scholarly journals GALECTIN-3, CARDIAC STRUCTURE AND FUNCTION, AND LONG-TERM MORTALITY IN PATIENTS WITH ACUTE HEART FAILURE

2010 ◽  
Vol 55 (10) ◽  
pp. A34.E329
Author(s):  
Ravi V. Shah ◽  
Annabel A. Chen-Tournoux ◽  
Michael H. Picard ◽  
Roland RJ van Kimmenade ◽  
James L. Januzzi
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Galectin 3 ◽  
Cardiac Structure And Function ◽  
And Function ◽  
Long Term Mortality

scholarly journals Characteristics, Outcomes and Predictors of Long-Term Mortality for Patients Hospitalized for Acute Heart Failure: A Report From the Korean Heart Failure Registry

2011 ◽  
Vol 41 (7) ◽  
pp. 363 ◽  
Author(s):  
Dong-Ju Choi ◽  
Seongwoo Han ◽  
Eun-Seok Jeon ◽  
Myeong-Chan Cho ◽  
Jae-Joong Kim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Long Term Mortality
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