scholarly journals The role of ventricular–arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases, European Association of Cardiovascular Imaging, and Heart Failure Association

2019 ◽  
Vol 21 (4) ◽  
pp. 402-424 ◽  
Author(s):  
Ignatios Ikonomidis ◽  
Victor Aboyans ◽  
Jacque Blacher ◽  
Marianne Brodmann ◽  
Dirk L. Brutsaert ◽  
...  
Keyword(s):  
Heart Failure ◽  
Vascular Diseases ◽  
Cardiovascular Imaging ◽  
Therapeutic Interventions ◽  
Clinical Implications ◽  
Peripheral Vascular ◽  
Consensus Document ◽  
Failure Assessment ◽  
European Society Of Cardiology

Abstract 865: Gata-4 Is An Angiogenic Survival Factor Of The Infarcted Heart

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Olli Tenhunen ◽  
Hanna Leskinen ◽  
Raisa Serpi ◽  
Jaana Rysä ◽  
Harri Pennanen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cells ◽  
Gene Transfer ◽  
Dna Binding ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Therapeutic Interventions ◽  
Cardiac Stem Cells

Recent data suggest that the cardiac-restricted transcription factor GATA-4 is an anti-apoptotic factor required for adaptive responses as well as a key regulator of hypertrophy and hypertrophy-associated genes in the heart. As a leading cause of chronic heart failure, reversal of post-infarction left ventricular remodeling represents an important target for therapeutic interventions. Here we studied the role of GATA-4 as a mediator of post-infarction remodeling. Rats were subjected to experimental myocardial infarction (MI) by ligating the left anterior descending coronary artery (LAD). Ligation of the LAD decreased the DNA binding activity of GATA-4 by 69 % at day 1 after MI (P<0.001, n=7– 8) as assessed by gel mobility shift assays. At 2 weeks the GATA-4 DNA binding was significantly upregulated (2.4-fold, P<0.05, n=7), and returned to baseline at 4 weeks. To determine the functional role of GATA-4, rats underwent LAD ligation followed by peri-infarct intramyocardial delivery of adenoviral vector expressing GATA-4. Hearts treated with the GATA-4 gene transfer exhibited significantly increased ejection fraction (58±5% vs. 38±3% in LacZ-treated control animals with MI, P<0.001, n=8 –9) and fractional shortening (28±3% vs. 16±1%, P<0.001, n=8 –9) 2 weeks after MI. Accordingly, the infarct size was significantly reduced (26±4% vs. 45±4%, P<0.01, n=8 –9). To determine the cardioprotective mechanisms of GATA-4, the number of cardiac stem cells, apoptotic cardiomyocytes and capillaries were assessed. The number of capillaries (59±4/field vs. 48±3/field, P<0.051, n=7– 8) and c-kit positive stem cells (13±5 cells vs. 4±2 cells, P<0.05, n=7– 8) were increased in GATA-4 treated hearts, and a tendency to decreased apoptosis was observed in TUNEL-stained histological sections. These results indicate that the reversal of reduced GATA-4 activity prevents adverse post-infarction remodeling through increased angiogenesis, recruitment of cardiac stem cells and anti-apoptosis. GATA-4-based gene transfer may represent a novel, efficient therapeutic approach for heart failure.

Potential role of endothelial progenitor cells in the pathophysiology of heart failure: Clinical implications and perspectives

2006 ◽  
Vol 189 (2) ◽  
pp. 247-254 ◽  
Author(s):  
Ioannis Andreou ◽  
Dimitris Tousoulis ◽  
Costas Tentolouris ◽  
Charalambos Antoniades ◽  
Christodoulos Stefanadis
Keyword(s):  
Heart Failure ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Potential Role ◽  
Clinical Implications ◽  
Endothelial Progenitor

scholarly journals Phase II trials in heart failure: The role of cardiovascular imaging

2011 ◽  
Vol 162 (1) ◽  
pp. 3-15.e3 ◽  
Author(s):  
Sanjiv J. Shah ◽  
Gregg C. Fonarow ◽  
Mihai Gheorghiade ◽  
Roberto M. Lang
Keyword(s):  
Heart Failure ◽  
Phase Ii ◽  
Cardiovascular Imaging ◽  
Phase Ii Trials

scholarly journals Heart failure: role of cardiovascular imaging

Medwave ◽  
2016 ◽  
Vol 16 (Suppl4) ◽  
pp. e6552-e6552 ◽  
Author(s):  
Rienzi Díaz Navarro
Keyword(s):  
Heart Failure ◽  
Cardiovascular Imaging
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