scholarly journals Age‐related longitudinal change in cardiac structure and function in adults at increased cardiovascular risk

2020 ◽  
Vol 7 (3) ◽  
pp. 1344-1361
Author(s):  
Fei Fei Gong ◽  
Jennifer M. Coller ◽  
Michele McGrady ◽  
Umberto Boffa ◽  
Louise Shiel ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Structure And Function ◽  
Longitudinal Change ◽  
Cardiac Structure ◽  
Age Related ◽  
Cardiac Structure And Function ◽  
And Function

scholarly journals Changes in cardiac structure and function with aging

2022 ◽  
Author(s):  
Tanushree Agrawal ◽  
Sherif F. Nagueh
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiac Remodeling ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Physiological Changes ◽  
Age Related ◽  
Cardiac Structure And Function ◽  
And Function

Aging is associated with progressive changes in cardiac structure and function. The prevalence of cardiovascular risk factors and disease also increases profoundly with advancing age. Therefore, understanding the spectrum of physiological changes in the aging heart is crucial for the identification and risk stratification of cardiovascular disease. In this review, we discuss echocardiographic features of age-related cardiac remodeling.

scholarly journals The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0185114 ◽  
Author(s):  
Steffen E. Petersen ◽  
Mihir M. Sanghvi ◽  
Nay Aung ◽  
Jackie A. Cooper ◽  
José Miguel Paiva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Uk Biobank ◽  
Cardiac Structure And Function ◽  
The Uk ◽  
And Function ◽  
The Impact

scholarly journals HEART AND AGE (PART II): CLINICAL MANIFESTATIONS OF AGEING

2013 ◽  
Vol 12 (4) ◽  
pp. 86-90 ◽  
Author(s):  
D. U. Akasheva ◽  
E. V. Plokhova ◽  
I. D. Strazhesko ◽  
E. N. Dudinskaya ◽  
O. N. Tkacheva
Keyword(s):  
Clinical Manifestations ◽  
The Elderly ◽  
Structure And Function ◽  
Disease Development ◽  
Cardiac Structure ◽  
Age Related ◽  
High Prevalence ◽  
Cardiac Structure And Function ◽  
And Function

Ageing is an inevitable process which affects quality of life and reduces life expectancy. Age-related cardiac changes reduce compensatory reserves of the heart and accelerate the disease development. Such changes in cardiac structure and function, observed in the absence of cardiovascular disease (CVD), are considered age-related. However, taking into account the high prevalence of CVD in the elderly, it is problematic to define the genuine cardiac ageing. This review discusses a range of subclinical cardiac conditions which are common in older people. 

Cardioprotective potential of lithium and role of fractalkine in euthymic patients with bipolar disorder

2021 ◽  
pp. 000486742110625
Author(s):  
Pao-Huan Chen ◽  
Cheng-Yi Hsiao ◽  
Shuo-Ju Chiang ◽  
Ruei-Siang Shen ◽  
Yen-Kuang Lin ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cardiovascular Risk ◽  
Lithium Treatment ◽  
Structure And Function ◽  
Cardiac Structure ◽  
High Cardiovascular Risk ◽  
Cohen’S D ◽  
Cardiac Structure And Function ◽  
And Function ◽  
Cohen's D

Objective: Over a half century, lithium has been used as the first-line medication to treat bipolar disorder. Emerging clinical and laboratory studies suggest that lithium may exhibit cardioprotective effects in addition to neuroprotective actions. Fractalkine (CX3CL1) is a unique chemokine associated with the pathogenesis of mood disorders and cardiovascular diseases. Herein we aimed to ascertain whether lithium treatment is associated with favorable cardiac structure and function in relation to the reduced CX3CL1 among patients with bipolar disorder. Methods: We recruited 100 euthymic patients with bipolar I disorder aged over 20 years to undergo echocardiographic study and measurement of plasma CX3CL1. Associations between lithium treatment, cardiac structure and function and peripheral CX3CL1 were analyzed according to the cardiovascular risk. The high cardiovascular risk was defined as (1) age ⩾ 45 years in men or ⩾ 55 years in women or (2) presence of concurrent cardiometabolic diseases. Results: In the high cardiovascular risk group ( n = 61), patients who received lithium as the maintenance treatment had significantly lower mean values of left ventricular internal diameters at end-diastole (Cohen’s d = 0.65, p = 0.001) and end-systole (Cohen’s d = 0.60, p = 0.004), higher mean values of mitral valve E/A ratio (Cohen’s d = 0.51, p = 0.019) and superior performance of global longitudinal strain (Cohen’s d = 0.51, p = 0.037) than those without lithium treatment. In addition, mean plasma levels of CX3CL1 in the high cardiovascular risk group were significantly lower among patients with lithium therapy compared with those without lithium treatment ( p = 0.029). Multiple regression models showed that the association between lithium treatment and mitral value E/A ratio was contributed by CX3CL1. Conclusion: Data from this largest sample size study of the association between lithium treatment and echocardiographic measures suggest that lithium may protect cardiac structure and function in patients with bipolar disorder. Reduction of CX3CL1 may mediate the cardioprotective effects of lithium.

Abstract 068: Hypertension And Longitudinal Changes In Cardiac Structure And Function In The Hispanic Community Health Study/Study Of Latinos: Echocardiographic Study Of Latinos (Echo-SOL) Ancillary Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Jennifer McLeod ◽  
Barry E Hurwitz ◽  
Daniela Sotres-Alvarez ◽  
Mayank M Kansal ◽  
Katrina Swett ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Structure And Function ◽  
Longitudinal Change ◽  
Longitudinal Impact ◽  
Cardiac Structure ◽  
Linear Regression Models ◽  
End Diastolic Volume ◽  
Cardiac Structure And Function ◽  
And Function

Introduction: Hypertension, one of the most modifiable risk factors of heart disease, induces cardiac remodeling and worsens myocardial function prior to the development of clinical symptoms. Using a comprehensive cohort of Hispanic/Latino adults, we assessed cardiac structure and function, in relation to hypertension, and the longitudinal impact of blood pressure control. Hypothesis: If baseline hypertensive adults are stratified by longitudinal blood pressure (BP) control, there will be differences in the progression of cardiac structure and function parameters. Methods: The Echo-SOL Ancillary Study provided serial comprehensive echocardiographic assessments of Hispanic adults aged 45-74 years. They were arranged into two groups based on the presence of baseline hypertension (>140/90mmHg). Linear regression models were used to estimate the association between baseline BP properties and the longitudinal change in echocardiogram parameters. We then subdivided each group based on whether the they maintained BP control (<140/90mmHg) on follow up and used linear regression models to test for significance among the mean longitudinal change of echocardiogram parameters. All analyses accounted for the complex sampling design of HCHS/SOL and Echo-SOL. Results: There was a total of 1818 adults at baseline, with 1643 obtaining serial echocardiograms an average of 4.3 years later, mean age of approximately 56 years. Among all adults, baseline pulse pressure was significantly associated with a longitudinal increase in left ventricular (LV) end diastolic volume (β=0.13, p=0.02), whereas the change in LV mass index longitudinally decreased with baseline diastolic BP (β=-0.14, p<0.01). When isolating the subgroup defined as hypertensive at baseline, the adults who had uncontrolled BP on follow up had a greater absolute increase in the average E/E’ ratio and greater decrease in average E’ velocity, 0.95±0.08 and -0.96±0.06 respectively, compared to the adults with controlled BP 0.04±0.07 and -0.74± 0.04 respectively (p<0.01). In addition, the controlled BP group had a greater absolute reduction in LV end-diastolic volume of 6.94mL than those with uncontrolled BP, 4.60mL (p<0.01). Conclusions: Our study is the first to study the association of longitudinal impact of blood pressure control with cardiac structure and function in Hispanic/Latino adults. We found that higher baseline brachial BP properties were associated with reduced in LV mass index and increased LV end diastolic volumes. Among the baseline hypertensive adults, there was a significantly higher progression in diastolic dysfunction among the participants who had poor BP control, but those with controlled BP on follow up had greater LV enlargement. Despite these differences, both subgroups ultimately showed a collective progression in diastolic dysfunction and a decrease in end-diastolic volume over time.

scholarly journals Puberty timing and markers of cardiovascular structure and function at 25 years: a prospective cohort study

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Gillian M. Maher ◽  
Lisa Ryan ◽  
Fergus P. McCarthy ◽  
Alun Hughes ◽  
Chloe Park ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cardiovascular Risk ◽  
Early Adulthood ◽  
Structure And Function ◽  
Height Velocity ◽  
Cardiac Structure ◽  
Cardiovascular Structure ◽  
Males And Females ◽  
Cardiac Structure And Function ◽  
And Function

Abstract Background Whether earlier onset of puberty is associated with higher cardiovascular risk in early adulthood is not well understood. Our objective was to examine the association between puberty timing and markers of cardiovascular structure and function at age 25 years. Methods We conducted a prospective birth cohort study using data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Participants were born between April 1, 1991, and December 31, 1992. Exposure of interest was age at peak height velocity (aPHV), an objective and validated growth-based measure of puberty onset. Outcome measures included cardiovascular structure and function at age 25 years: carotid intima-media thickness (CIMT), left ventricular mass index (LVMI) and relative wall thickness (RWT), pulse wave velocity (PWV) and systolic blood pressure (SBP). Multiple imputation was used to impute missing data on covariates and outcomes. Linear regression was used to examine the association between aPHV and each measure of cardiac structure and function, adjusting for maternal age, gestational age, household social class, maternal education, mother’s partner’s education, breastfeeding, parity, birthweight, maternal body mass index, maternal marital status, maternal prenatal smoking status and height and fat mass at age 9. All analyses were stratified by sex. Results A total of 2752–4571 participants were included in the imputed analyses. A 1-year older aPHV was not strongly associated with markers of cardiac structure and function in males and females at 25 years and most results spanned the null value. In adjusted analyses, a 1-year older aPHV was associated with 0.003 mm (95% confidence interval (CI) 0.00001, 0.006) and 0.0008 mm (95% CI − 0.002, 0.003) higher CIMT; 0.02 m/s (95% CI − 0.05, 0.09) and 0.02 m/s (95% CI − 0.04, 0.09) higher PWV; and 0.003 mmHg (95% CI − 0.60, 0.60) and 0.13 mmHg (95% CI − 0.44, 0.70) higher SBP, among males and females, respectively. A 1-year older aPHV was associated with − 0.55 g/m2.7 (95% CI − 0.03, − 1.08) and − 0.89 g/m2.7 (95% CI − 0.45, − 1.34) lower LVMI and − 0.001 (95% CI − 0.006, 0.002) and − 0.002 (95% CI − 0.006, 0.002) lower RWT among males and females. Conclusions Earlier puberty is unlikely to have a major impact on pre-clinical cardiovascular risk in early adulthood.

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