scholarly journals Re‐evaluating the prevalence and factors characteristic of catecholamine secreting head and neck paragangliomas

2021 ◽  
Author(s):  
Joshua D. Smith ◽  
Susan E. Ellsperman ◽  
Gregory J. Basura ◽  
Tobias Else
Keyword(s):  
Head And Neck ◽  
Head And Neck Paragangliomas

Head and Neck Paragangliomas Radiosurgery: Long-Term, Single-Institution Experience

2016 ◽  
Vol 77 (S 02) ◽  
Author(s):  
Marcello Marchetti ◽  
Valentina Pinzi ◽  
Francesco Prada ◽  
Elena De Martin ◽  
Valeria Cuccarini ◽  
...  
Keyword(s):  
Head And Neck ◽  
Single Institution ◽  
Head And Neck Paragangliomas

SDHB, SDHC, and SDHD Mutations in Head and Neck Paragangliomas

Skull Base ◽  
2007 ◽  
Vol 17 (S 1) ◽  
Author(s):  
Franco Trabalzini ◽  
Francesca Schiavi ◽  
Giuseppe Opocher ◽  
Pietro Amistà
Keyword(s):  
Head And Neck ◽  
Head And Neck Paragangliomas

Malignant Head and Neck Paragangliomas in Patients with Paraganglioma Syndromes

Skull Base ◽  
2009 ◽  
Vol 19 (01) ◽  
Author(s):  
Carsten Boedeker ◽  
Zoran Erlic ◽  
Roland Laszig ◽  
Wolfgang Maier ◽  
Jörg Schipper ◽  
...  
Keyword(s):  
Head And Neck ◽  
Head And Neck Paragangliomas

Head and neck paragangliomas: genetic mutation and location of the tumors

2018 ◽  
Author(s):  
Jose-Maria Recio-Cordova ◽  
Cecilia Higueruela ◽  
Rocio Caceres ◽  
Maria Garcia-Duque ◽  
Rogelio Gonzalez-Sarmiento ◽  
...  
Keyword(s):  
Head And Neck ◽  
Genetic Mutation ◽  
Head And Neck Paragangliomas

scholarly journals Head and neck paragangliomas: Ten years of experience in a third health center. A cohort study

2021 ◽  
pp. 102412
Author(s):  
Merzouqi Boutaina ◽  
El Bouhmadi Khadija ◽  
Oukessou Youssef ◽  
Rouadi Sami ◽  
Abada Redallah Larbi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Head And Neck ◽  
Health Center ◽  
Years Of Experience ◽  
Head And Neck Paragangliomas

scholarly journals Management of Multiple Head and Neck Paragangliomas With Assistance of a 3-D Model

2021 ◽  
pp. 014556132110094
Author(s):  
Lifeng Li ◽  
Hongbo Xu ◽  
Xiaohong Chen ◽  
Zhenya Yu ◽  
Jing Zhou ◽  
...  
Keyword(s):  
Head And Neck ◽  
Genomic Analysis ◽  
Study Cohort ◽  
Bilateral Carotid ◽  
Succinate Dehydrogenase Complex ◽  
Carotid Body Tumors ◽  
D Model ◽  
Vessel Rupture ◽  
Head And Neck Paragangliomas ◽  
Succinate Dehydrogenase Complex Subunit

Introduction: Extirpation of multiple head and neck paragangliomas carries challenge due to close anatomic relationships with critical neurovascular bundles. Objectives: This study aims to assess whether the application of 3-D models can assist with surgical planning and treatment of these paragangliomas, decrease surgically related morbidity and mortality. Methods: Fourteen patients undergoing surgical resection of multiple head and neck paragangliomas were enrolled in this study. A preoperative 3-D model was created based on radiologic data, and relevant critical anatomic relationships were preoperatively assessed and intraoperatively validated. Results: All 14 patients presented with multiple head and neck paragangliomas, including bilateral carotid body tumors (CBT, n = 9), concurrent CBT with glomus jugulare tumors (GJT, n = 4), and multiple vagal paragangliomas (n = 1). Ten patients underwent genomic analysis and all harbored succinate dehydrogenase complex subunit D (SDHD) mutations. Under guidance of the 3-D model, the internal carotid artery (ICA) was circumferentially encased by tumor on 5 of the operated sides, in 4 (80%) of which the tumor was successfully dissected out from the ICA, whereas ICA reconstruction was required on one side (20%). Following removal of CBT, anterior rerouting of the facial nerve was avoided in 3 (75%) of 4 patients during the extirpation of GJT with assistance of a 3-D model. Two patients developed permanent postoperative vocal cord paralysis. There was no vessel rupture or mortality in this study cohort. Conclusion: The 3-D model is beneficial for establishment of a preoperative strategy, as well as planning and guiding the intraoperative procedure for resection of multiple head and neck paragangliomas.

Soluble Endoglin (CD105) Serum Level as a Potential Marker in the Management of Head and Neck Paragangliomas

2017 ◽  
Vol 126 (10) ◽  
pp. 717-721 ◽  
Author(s):  
Małgorzata Litwiniuk ◽  
Kazimierz Niemczyk ◽  
Justyna Niderla-Bielińska ◽  
Izabela Łukawska-Popieluch ◽  
Tomasz Grzela
Keyword(s):  
Serum Level ◽  
Head And Neck ◽  
Potential Marker ◽  
Soluble Endoglin ◽  
Head And Neck Paragangliomas

Urinary 5-HIAA Excretion is not Increased in Patients with Head and Neck Paragangliomas

2012 ◽  
Vol 27 (2) ◽  
pp. 160-163 ◽  
Author(s):  
Leonie T. Van Hulsteijn ◽  
Nicolette Van Duinen ◽  
Johannes A. Romijn ◽  
Johannes W.A. Smit ◽  
Eleonora P.M. Corssmit
Keyword(s):  
Urinary Excretion ◽  
Head And Neck ◽  
Reference Range ◽  
Excretion Rate ◽  
Case Reports ◽  
Catecholamine Excess ◽  
Hydroxyindoleacetic Acid ◽  
Excretion Rates ◽  
Almost All ◽  
Head And Neck Paragangliomas

Background Case reports have documented carcinoid-like features in head and neck paragangliomas (HNPGLs), which, in addition to catecholamine storing granules, may also contain granules with serotonin. Serotonin is metabolized to 5-hydroxyindoleacetic acid (5-HIAA). Aim To assess the urinary excretion rates of 5-HIAA and catecholamines in HNPGL patients. Methods In 114 consecutive HNPGL patients, normetanephrine, metanephrine, norepinephrine, epinephrine, VMA, dopamine, 3-methoxytyramine and 5-HIAA excretion rates were measured in two 24-hour urinary samples. Increased excretion rates were defined as an increase of the average hormone excretion rate of 2 urine samples above the reference range. In all patients with catecholamine excess, intrathoracic and abdominal paragangliomas were excluded by 123I-MIBG scintigraphy, MRI and/or CT. Genetic screening for mutations in genes of the succinate dehydrogenase (SDH) family was performed. Results Mean urinary 5-HIAA excretion rate was 14±9 μmol/24 hours (reference range 10–44 μmol/24 hours). Urinary 5-HIAA excretion was slightly increased in only 1 patient (48 μmol/24 hours). None of the 50 patients (44%) with increased urinary excretion rates of catecholamines and/or their metabolites had elevated 5-HIAA excretion. Conclusion Urinary 5-HIAA excretion is within the normal reference range in almost all HNPGL patients. Therefore, this parameter has no clinical relevance in the routine clinical assessment of HNPGL patients.

scholarly journals Head and neck paragangliomas: A two-decade institutional experience and algorithm for management

2017 ◽  
Vol 2 (6) ◽  
pp. 380-389 ◽  
Author(s):  
Joshua D. Smith ◽  
Rachel N. Harvey ◽  
Owen A. Darr ◽  
Mark E. Prince ◽  
Carol R. Bradford ◽  
...  
Keyword(s):  
Head And Neck ◽  
Institutional Experience ◽  
Head And Neck Paragangliomas
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