scholarly journals Head and neck paragangliomas: A two-decade institutional experience and algorithm for management

2017 ◽  
Vol 2 (6) ◽  
pp. 380-389 ◽  
Author(s):  
Joshua D. Smith ◽  
Rachel N. Harvey ◽  
Owen A. Darr ◽  
Mark E. Prince ◽  
Carol R. Bradford ◽  
...  
Keyword(s):  
Head And Neck ◽  
Institutional Experience ◽  
Head And Neck Paragangliomas

Proton therapy for head and neck paragangliomas: A single institutional experience

Head & Neck ◽  
2020 ◽  
Vol 42 (4) ◽  
pp. 670-677
Author(s):  
Kylie H. Kang ◽  
Emily S. Lebow ◽  
Andrzej Niemierko ◽  
Marc R. Bussière ◽  
Nicholas A. Dewyer ◽  
...  
Keyword(s):  
Head And Neck ◽  
Proton Therapy ◽  
Institutional Experience ◽  
Head And Neck Paragangliomas

Head and Neck Paragangliomas Radiosurgery: Long-Term, Single-Institution Experience

2016 ◽  
Vol 77 (S 02) ◽  
Author(s):  
Marcello Marchetti ◽  
Valentina Pinzi ◽  
Francesco Prada ◽  
Elena De Martin ◽  
Valeria Cuccarini ◽  
...  
Keyword(s):  
Head And Neck ◽  
Single Institution ◽  
Head And Neck Paragangliomas

SDHB, SDHC, and SDHD Mutations in Head and Neck Paragangliomas

Skull Base ◽  
2007 ◽  
Vol 17 (S 1) ◽  
Author(s):  
Franco Trabalzini ◽  
Francesca Schiavi ◽  
Giuseppe Opocher ◽  
Pietro Amistà
Keyword(s):  
Head And Neck ◽  
Head And Neck Paragangliomas

Malignant Head and Neck Paragangliomas in Patients with Paraganglioma Syndromes

Skull Base ◽  
2009 ◽  
Vol 19 (01) ◽  
Author(s):  
Carsten Boedeker ◽  
Zoran Erlic ◽  
Roland Laszig ◽  
Wolfgang Maier ◽  
Jörg Schipper ◽  
...  
Keyword(s):  
Head And Neck ◽  
Head And Neck Paragangliomas

Head and neck paragangliomas: genetic mutation and location of the tumors

2018 ◽  
Author(s):  
Jose-Maria Recio-Cordova ◽  
Cecilia Higueruela ◽  
Rocio Caceres ◽  
Maria Garcia-Duque ◽  
Rogelio Gonzalez-Sarmiento ◽  
...  
Keyword(s):  
Head And Neck ◽  
Genetic Mutation ◽  
Head And Neck Paragangliomas

scholarly journals Head and neck paragangliomas: Ten years of experience in a third health center. A cohort study

2021 ◽  
pp. 102412
Author(s):  
Merzouqi Boutaina ◽  
El Bouhmadi Khadija ◽  
Oukessou Youssef ◽  
Rouadi Sami ◽  
Abada Redallah Larbi ◽  
...  
Keyword(s):  
Cohort Study ◽  
Head And Neck ◽  
Health Center ◽  
Years Of Experience ◽  
Head And Neck Paragangliomas

scholarly journals Management of Multiple Head and Neck Paragangliomas With Assistance of a 3-D Model

2021 ◽  
pp. 014556132110094
Author(s):  
Lifeng Li ◽  
Hongbo Xu ◽  
Xiaohong Chen ◽  
Zhenya Yu ◽  
Jing Zhou ◽  
...  
Keyword(s):  
Head And Neck ◽  
Genomic Analysis ◽  
Study Cohort ◽  
Bilateral Carotid ◽  
Succinate Dehydrogenase Complex ◽  
Carotid Body Tumors ◽  
D Model ◽  
Vessel Rupture ◽  
Head And Neck Paragangliomas ◽  
Succinate Dehydrogenase Complex Subunit

Introduction: Extirpation of multiple head and neck paragangliomas carries challenge due to close anatomic relationships with critical neurovascular bundles. Objectives: This study aims to assess whether the application of 3-D models can assist with surgical planning and treatment of these paragangliomas, decrease surgically related morbidity and mortality. Methods: Fourteen patients undergoing surgical resection of multiple head and neck paragangliomas were enrolled in this study. A preoperative 3-D model was created based on radiologic data, and relevant critical anatomic relationships were preoperatively assessed and intraoperatively validated. Results: All 14 patients presented with multiple head and neck paragangliomas, including bilateral carotid body tumors (CBT, n = 9), concurrent CBT with glomus jugulare tumors (GJT, n = 4), and multiple vagal paragangliomas (n = 1). Ten patients underwent genomic analysis and all harbored succinate dehydrogenase complex subunit D (SDHD) mutations. Under guidance of the 3-D model, the internal carotid artery (ICA) was circumferentially encased by tumor on 5 of the operated sides, in 4 (80%) of which the tumor was successfully dissected out from the ICA, whereas ICA reconstruction was required on one side (20%). Following removal of CBT, anterior rerouting of the facial nerve was avoided in 3 (75%) of 4 patients during the extirpation of GJT with assistance of a 3-D model. Two patients developed permanent postoperative vocal cord paralysis. There was no vessel rupture or mortality in this study cohort. Conclusion: The 3-D model is beneficial for establishment of a preoperative strategy, as well as planning and guiding the intraoperative procedure for resection of multiple head and neck paragangliomas.

Soluble Endoglin (CD105) Serum Level as a Potential Marker in the Management of Head and Neck Paragangliomas

2017 ◽  
Vol 126 (10) ◽  
pp. 717-721 ◽  
Author(s):  
Małgorzata Litwiniuk ◽  
Kazimierz Niemczyk ◽  
Justyna Niderla-Bielińska ◽  
Izabela Łukawska-Popieluch ◽  
Tomasz Grzela
Keyword(s):  
Serum Level ◽  
Head And Neck ◽  
Potential Marker ◽  
Soluble Endoglin ◽  
Head And Neck Paragangliomas

Urinary 5-HIAA Excretion is not Increased in Patients with Head and Neck Paragangliomas

2012 ◽  
Vol 27 (2) ◽  
pp. 160-163 ◽  
Author(s):  
Leonie T. Van Hulsteijn ◽  
Nicolette Van Duinen ◽  
Johannes A. Romijn ◽  
Johannes W.A. Smit ◽  
Eleonora P.M. Corssmit
Keyword(s):  
Urinary Excretion ◽  
Head And Neck ◽  
Reference Range ◽  
Excretion Rate ◽  
Case Reports ◽  
Catecholamine Excess ◽  
Hydroxyindoleacetic Acid ◽  
Excretion Rates ◽  
Almost All ◽  
Head And Neck Paragangliomas

Background Case reports have documented carcinoid-like features in head and neck paragangliomas (HNPGLs), which, in addition to catecholamine storing granules, may also contain granules with serotonin. Serotonin is metabolized to 5-hydroxyindoleacetic acid (5-HIAA). Aim To assess the urinary excretion rates of 5-HIAA and catecholamines in HNPGL patients. Methods In 114 consecutive HNPGL patients, normetanephrine, metanephrine, norepinephrine, epinephrine, VMA, dopamine, 3-methoxytyramine and 5-HIAA excretion rates were measured in two 24-hour urinary samples. Increased excretion rates were defined as an increase of the average hormone excretion rate of 2 urine samples above the reference range. In all patients with catecholamine excess, intrathoracic and abdominal paragangliomas were excluded by 123I-MIBG scintigraphy, MRI and/or CT. Genetic screening for mutations in genes of the succinate dehydrogenase (SDH) family was performed. Results Mean urinary 5-HIAA excretion rate was 14±9 μmol/24 hours (reference range 10–44 μmol/24 hours). Urinary 5-HIAA excretion was slightly increased in only 1 patient (48 μmol/24 hours). None of the 50 patients (44%) with increased urinary excretion rates of catecholamines and/or their metabolites had elevated 5-HIAA excretion. Conclusion Urinary 5-HIAA excretion is within the normal reference range in almost all HNPGL patients. Therefore, this parameter has no clinical relevance in the routine clinical assessment of HNPGL patients.

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