scholarly journals Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird

2018 ◽  
Vol 8 (13) ◽  
pp. 6547-6557 ◽  
Author(s):  
Carl D. Soulsbury ◽  
Anssi Lipponen ◽  
Kristie Wood ◽  
Charles A. Mein ◽  
Joseph I. Hoffman ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Wild Bird

scholarly journals The effect of experimental lead pollution on DNA methylation in a wild bird population

Epigenetics ◽  
2021 ◽  
pp. 1-17
Author(s):  
Hannu Mäkinen ◽  
Kees van Oers ◽  
Tapio Eeva ◽  
Suvi Ruuskanen
Keyword(s):  
Dna Methylation ◽  
Wild Bird ◽  
Lead Pollution ◽  
Bird Population

scholarly journals Genome‐wide variation in DNA methylation is associated with stress resilience and plumage brightness in a wild bird

2019 ◽  
Vol 28 (16) ◽  
pp. 3722-3737 ◽  
Author(s):  
Conor C. Taff ◽  
Leonardo Campagna ◽  
Maren N. Vitousek
Keyword(s):  
Dna Methylation ◽  
Wild Bird ◽  
Stress Resilience ◽  
Genome Wide

scholarly journals Dynamic changes in DNA methylation during embryonic and postnatal development of an altricial wild bird

2019 ◽  
Vol 9 (17) ◽  
pp. 9580-9585 ◽  
Author(s):  
Hannah Watson ◽  
Pablo Salmón ◽  
Caroline Isaksson
Keyword(s):  
Dna Methylation ◽  
Postnatal Development ◽  
Wild Bird ◽  
Dynamic Changes

scholarly journals Does Arsenic Contamination Affect DNA Methylation Patterns in a Wild Bird Population? An Experimental Approach

2021 ◽  
Author(s):  
Veronika N. Laine ◽  
Mark Verschuuren ◽  
Kees van Oers ◽  
Silvia Espín ◽  
Pablo Sánchez-Virosta ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Wild Bird ◽  
Experimental Approach ◽  
Arsenic Contamination ◽  
Bird Population ◽  
Methylation Patterns

scholarly journals The effect of experimental lead pollution on DNA methylation in a wild bird population

2019 ◽  
Author(s):  
Hannu Mäkinen ◽  
Kees van Oers ◽  
Tapio Eeva ◽  
Veronika N. Laine ◽  
Suvi Ruuskanen
Keyword(s):  
Dna Methylation ◽  
Heavy Metal ◽  
Wild Bird ◽  
Parus Major ◽  
Anthropogenic Pollution ◽  
Copper Smelter ◽  
Metal Exposure ◽  
Heavy Metal Exposure ◽  
Bird Population ◽  
Early Life Exposure

AbstractAnthropogenic pollution is known to negatively influence an organism’s physiology, behavior and fitness. Epigenetic regulation, such as DNA methylation, has been hypothesized as one mechanism to mediate such effects, yet studies in wild species are lacking. We first investigated the effects of early-life exposure to the heavy metal lead (Pb) on DNA methylation levels in a wild population of great tits (Parus major), by experimentally exposing nestlings to lead at environmentally relevant levels. Secondly, we studied the effects of heavy metal exposure in a population close to a copper smelter, where birds suffer from pollution-related decrease in food quality. For both comparisons, the analysis of about million CpGs covering most of the annotated genes, revealed that regions enriched for developmental processes showed pollution-related changes in DNA methylation, but the results were not consistent with binomial and beta binomial regression. Our study indicates that post-natal anthropogenic heavy metal exposure can affect methylation levels of development related genes in a wild bird population.

scholarly journals Does arsenic contamination affect DNA methylation patterns in a wild bird population? An experimental approach

2020 ◽  
Author(s):  
Veronika N. Laine ◽  
Mark Verschuuren ◽  
Kees van Oers ◽  
Silvia Espín ◽  
Pablo Sánchez-Virosta ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Wild Bird ◽  
Methylation Status ◽  
Parus Major ◽  
Model Organisms ◽  
Bird Population ◽  
Early Life Exposure ◽  
Animal Populations ◽  
And Performance ◽  
Methylation Patterns

AbstractPollutants, like toxic metals, negatively influence organismal health and performance, even leading to population collapses. Studies in model organisms have shown that epigenetic marks, such as DNA methylation, can be modulated by various environmental factors, including pollutants, influencing gene expression and various organismal traits. Yet experimental data on the effects of pollution on DNA methylation from wild animal populations is largely lacking. We here investigated experimentally for the first time the effects of early-life exposure to environmentally relevant levels of a key pollutant, arsenic (As) on genome-wide DNA methylation status in a wild bird population. We experimentally exposed nestlings of great tits (Parus major) to arsenic during their post-natal developmental period (3 to 14 days post-hatching) and compared their DNA methylation levels to those of respective controls. In contrast to predictions, we found no overall hypomethylation in the arsenic group. We found evidence for loci to be differentially methylated between the treatment groups, but for five CpG sites only. This may be explained by the heterogenous, environment, relatively low dose (compared to previous laboratory studies), or choice of tissue. Further studies are needed to evaluate whether epigenetic dysregulation is a commonly observed phenomena in polluted populations, and what are its consequences for organism functioning and for populations.

DNA methylation in satellite repeats disorders

2019 ◽  
Vol 63 (6) ◽  
pp. 757-771 ◽  
Author(s):  
Claire Francastel ◽  
Frédérique Magdinier
Keyword(s):  
Dna Methylation ◽  
Human Genome ◽  
Repetitive Dna ◽  
Dna Sequences ◽  
Satellite Repeats ◽  
Tremendous Progress ◽  
Genes Encoding ◽  
Dna Elements ◽  
Near Future

Abstract Despite the tremendous progress made in recent years in assembling the human genome, tandemly repeated DNA elements remain poorly characterized. These sequences account for the vast majority of methylated sites in the human genome and their methylated state is necessary for this repetitive DNA to function properly and to maintain genome integrity. Furthermore, recent advances highlight the emerging role of these sequences in regulating the functions of the human genome and its variability during evolution, among individuals, or in disease susceptibility. In addition, a number of inherited rare diseases are directly linked to the alteration of some of these repetitive DNA sequences, either through changes in the organization or size of the tandem repeat arrays or through mutations in genes encoding chromatin modifiers involved in the epigenetic regulation of these elements. Although largely overlooked so far in the functional annotation of the human genome, satellite elements play key roles in its architectural and topological organization. This includes functions as boundary elements delimitating functional domains or assembly of repressive nuclear compartments, with local or distal impact on gene expression. Thus, the consideration of satellite repeats organization and their associated epigenetic landmarks, including DNA methylation (DNAme), will become unavoidable in the near future to fully decipher human phenotypes and associated diseases.

15 LONGITUDINAL EVALUATION OF MUCOSAL DNA METHYLATION IN ULCERATIVE COLITIS SHOWS DISEASE-SPECIFIC CHANGES

2020 ◽  
Vol 158 (3) ◽  
pp. S50-S51
Author(s):  
Suresh Venkateswaran ◽  
Varun Kilaru ◽  
Hari Somineni ◽  
Jason Matthews ◽  
Jeffrey Hyams ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dna Methylation ◽  
Longitudinal Evaluation ◽  
Disease Specific
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