scholarly journals The effect of experimental lead pollution on DNA methylation in a wild bird population

2019 ◽  
Author(s):  
Hannu Mäkinen ◽  
Kees van Oers ◽  
Tapio Eeva ◽  
Veronika N. Laine ◽  
Suvi Ruuskanen
Keyword(s):  
Dna Methylation ◽  
Heavy Metal ◽  
Wild Bird ◽  
Parus Major ◽  
Anthropogenic Pollution ◽  
Copper Smelter ◽  
Metal Exposure ◽  
Heavy Metal Exposure ◽  
Bird Population ◽  
Early Life Exposure

AbstractAnthropogenic pollution is known to negatively influence an organism’s physiology, behavior and fitness. Epigenetic regulation, such as DNA methylation, has been hypothesized as one mechanism to mediate such effects, yet studies in wild species are lacking. We first investigated the effects of early-life exposure to the heavy metal lead (Pb) on DNA methylation levels in a wild population of great tits (Parus major), by experimentally exposing nestlings to lead at environmentally relevant levels. Secondly, we studied the effects of heavy metal exposure in a population close to a copper smelter, where birds suffer from pollution-related decrease in food quality. For both comparisons, the analysis of about million CpGs covering most of the annotated genes, revealed that regions enriched for developmental processes showed pollution-related changes in DNA methylation, but the results were not consistent with binomial and beta binomial regression. Our study indicates that post-natal anthropogenic heavy metal exposure can affect methylation levels of development related genes in a wild bird population.

scholarly journals Does arsenic contamination affect DNA methylation patterns in a wild bird population? An experimental approach

2020 ◽  
Author(s):  
Veronika N. Laine ◽  
Mark Verschuuren ◽  
Kees van Oers ◽  
Silvia Espín ◽  
Pablo Sánchez-Virosta ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Wild Bird ◽  
Methylation Status ◽  
Parus Major ◽  
Model Organisms ◽  
Bird Population ◽  
Early Life Exposure ◽  
Animal Populations ◽  
And Performance ◽  
Methylation Patterns

AbstractPollutants, like toxic metals, negatively influence organismal health and performance, even leading to population collapses. Studies in model organisms have shown that epigenetic marks, such as DNA methylation, can be modulated by various environmental factors, including pollutants, influencing gene expression and various organismal traits. Yet experimental data on the effects of pollution on DNA methylation from wild animal populations is largely lacking. We here investigated experimentally for the first time the effects of early-life exposure to environmentally relevant levels of a key pollutant, arsenic (As) on genome-wide DNA methylation status in a wild bird population. We experimentally exposed nestlings of great tits (Parus major) to arsenic during their post-natal developmental period (3 to 14 days post-hatching) and compared their DNA methylation levels to those of respective controls. In contrast to predictions, we found no overall hypomethylation in the arsenic group. We found evidence for loci to be differentially methylated between the treatment groups, but for five CpG sites only. This may be explained by the heterogenous, environment, relatively low dose (compared to previous laboratory studies), or choice of tissue. Further studies are needed to evaluate whether epigenetic dysregulation is a commonly observed phenomena in polluted populations, and what are its consequences for organism functioning and for populations.

Effects of heavy metal exposure on the condition and health of nestlings of the great tit (Parus major), a small songbird species

2003 ◽  
Vol 126 (2) ◽  
pp. 267-274 ◽  
Author(s):  
Ellen Janssens ◽  
Tom Dauwe ◽  
Rianne Pinxten ◽  
Lieven Bervoets ◽  
Ronny Blust ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Parus Major ◽  
Great Tit ◽  
Metal Exposure ◽  
Heavy Metal Exposure

Bioaccessibility-corrected health risk of heavy metal exposure via shellfish consumption in coastal region of China

2021 ◽  
Vol 273 ◽  
pp. 116529
Author(s):  
Minwei Chai ◽  
Ruili Li ◽  
Yuan Gong ◽  
Xiaoxue Shen ◽  
Lingyun Yu
Keyword(s):  
Heavy Metal ◽  
Health Risk ◽  
Coastal Region ◽  
Metal Exposure ◽  
Heavy Metal Exposure

scholarly journals Relationship between heavy metal exposure and type 2 diabetes: a large-scale retrospective cohort study using occupational health examinations

BMJ Open ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. e039541
Author(s):  
Jun Ho Ji ◽  
Mi Hyeon Jin ◽  
Jung-Hun Kang ◽  
Soon Il Lee ◽  
Suee Lee ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Type 2 Diabetes ◽  
Heavy Metal ◽  
Cohort Study ◽  
Retrospective Cohort ◽  
Metal Exposure ◽  
Heavy Metal Exposure ◽  
Lead And Cadmium

ObjectivesTo investigate the associations between heavy metal exposure and serum ferritin levels, physical measurements and type 2 diabetes mellitus (DM).DesignA retrospective cohort study.SettingChangwon, the location of this study, is a Korean representative industrial city. Data were obtained from medical check-ups between 2002 and 2018.ParticipantsA total of 34 814 male subjects were included. Of them, 1035 subjects with lead exposure, 200 subjects with cadmium exposure and the 33 579 remaining were assigned to cohort A, cohort B and the control cohort, respectively. Data including personal history of alcohol and smoking, age, height, weight, the follow-up duration, haemoglobin A1c (HbA1c), fasting blood sugar (FBS), ferritin levels, and lead and cadmium levels within 1 year after exposure were collected.Primary outcome measureIn subjects without diabetes, changes in FBS and HbA1c were analysed through repeated tests at intervals of 1 year or longer after the occupational exposure to heavy metals.ResultsIn Cohort A, DM was diagnosed in 33 subjects. There was a significant difference in lead concentrations between the subjects diagnosed with DM and those without DM during the follow-up period (3.94±2.92 mg/dL vs 2.81±2.03 mg/dL, p=0.002). Simple exposure to heavy metals (lead and cadmium) was not associated with DM in Cox regression models (lead exposure (HR) 1.01, 95% CI: 0.58 to 1.77, p 0.971; cadmium exposure HR 1.48, 95% CI: 0.61 to 3.55, p=0.385). Annual changes in FBS according to lead concentration at the beginning of exposure showed a positive correlation (r=0.072, p=0.032).ConclusionOur findings demonstrated that simple occupational exposure to heavy metals lead and cadmium was not associated with the incidence of DM. However, lead concentrations at the beginning of the exposure might be an indicator of DM and glucose elevations.

scholarly journals Environmental Heavy Metal Exposure and Chronic Kidney Disease in the General Population

2015 ◽  
Vol 30 (3) ◽  
pp. 272 ◽  
Author(s):  
Nam Hee Kim ◽  
Young Youl Hyun ◽  
Kyu-Beck Lee ◽  
Yoosoo Chang ◽  
Seungho Rhu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Heavy Metal ◽  
Kidney Disease ◽  
General Population ◽  
Metal Exposure ◽  
Heavy Metal Exposure

scholarly journals The effect of experimental lead pollution on DNA methylation in a wild bird population

Epigenetics ◽  
2021 ◽  
pp. 1-17
Author(s):  
Hannu Mäkinen ◽  
Kees van Oers ◽  
Tapio Eeva ◽  
Suvi Ruuskanen
Keyword(s):  
Dna Methylation ◽  
Wild Bird ◽  
Lead Pollution ◽  
Bird Population
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