scholarly journals An N‐terminal fusion allele to study melanin concentrating hormone receptor 1

genesis ◽  
2021 ◽  
Author(s):  
Kalene R. Jasso ◽  
Tisianna K. Kamba ◽  
Arthur D. Zimmerman ◽  
Ruchi Bansal ◽  
Staci E. Engle ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Melanin Concentrating Hormone

Development of a Novel Carbon-11 Labeled PET Radioligand for Melanin- Concentrating Hormone Receptor 1

2017 ◽  
Vol 10 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Christer Halldin ◽  
Akihiro Takano ◽  
Miklos Toth ◽  
Marie Svedberg ◽  
Jenny Haggkvist ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Melanin Concentrating Hormone

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists

2012 ◽  
Vol 22 (9) ◽  
pp. 3157-3162 ◽  
Author(s):  
Sanjita Sasmal ◽  
Gade Balaji ◽  
Hariprasada R. Kanna Reddy ◽  
D. Balasubrahmanyam ◽  
Gujjary Srinivas ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Design And Optimization ◽  
Melanin Concentrating Hormone ◽  
Quinazoline Derivatives

New Amide Derivatives as Melanin-concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity

2011 ◽  
Vol 58 (11) ◽  
pp. 585-591
Author(s):  
Nuria Cirauqui ◽  
Javier Ceras ◽  
Silvia Galiano ◽  
Silvia Pérez-Silanes ◽  
Laura Juanenea ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Amide Derivatives ◽  
Melanin Concentrating Hormone ◽  
Treatment Of Obesity

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2

2012 ◽  
Vol 22 (9) ◽  
pp. 3163-3167 ◽  
Author(s):  
Sanjita Sasmal ◽  
D. Balasubrahmanyam ◽  
Hariprasada R. Kanna Reddy ◽  
Gade Balaji ◽  
Gujjary Srinivas ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Design And Optimization ◽  
Melanin Concentrating Hormone ◽  
Quinazoline Derivatives

Neurotensin Enhances Locomotor Activity and Arousal and Inhibits Melanin-Concentrating Hormone Signaling

2019 ◽  
Vol 110 (1-2) ◽  
pp. 35-49 ◽  
Author(s):  
Talia Levitas-Djerbi ◽  
Dana Sagi ◽  
Ilana Lebenthal-Loinger ◽  
Tali Lerer-Goldshtein ◽  
Lior Appelbaum
Keyword(s):  
Locomotor Activity ◽  
Hormone Receptor ◽  
Behavioral Response ◽  
Hormone Signaling ◽  
Wild Type ◽  
Expression Levels ◽  
Physiological Processes ◽  
Melanin Concentrating Hormone ◽  
Behavioral Assays

Background: Hypothalamic neurotensin (Nts)-secreting neurons regulate fundamental physiological processes including metabolism and feeding. However, the role of Nts in modulation of locomotor activity, sleep, and arousal is unclear. We previously identified and characterized Nts neurons in the zebrafish hypothalamus. Materials and Methods: In order to study the role of Nts, nts mutant (nts–/–), and overexpressing zebrafish were generated. Results: The expression of both nts mRNA and Nts protein was reduced during the night in wild-type zebrafish. Behavioral assays revealed that locomotor activity was decreased during both day and night, while sleep was increased exclusively during the nighttime in nts–/– larvae. Likewise, inducible overexpression of Nts increased arousal in hsp70:Gal4/uas:Nts larvae. Furthermore, the behavioral response to light-to-dark transitions was reduced in nts–/– larvae. In order to elucidate potential contenders that may mediate Nts action on these behaviors, we profiled the transcriptome of 6 dpf nts–/– larvae. Among other genes, the expression levels of melanin-concentrating hormone receptor 1b were increased in nts–/– larvae. Furthermore, a portion of promelanin-concentrating hormone 1 (pmch1) and pmch2 neurons expressed the nts receptor. In addition, expression of the the two zebrafish melanin-concentrating hormone (Mch) orthologs, Mch1 and Mch2, was increased in nts–/– larvae. Conclusion: These results show that the Nts and Mch systems interact and modulate locomotor activity and arousal.

Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2

2012 ◽  
Vol 22 (1) ◽  
pp. 363-366 ◽  
Author(s):  
Xiaoqi Chen ◽  
Jeff Mihalic ◽  
Pingchen Fan ◽  
Lingming Liang ◽  
Michelle Lindstrom ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Selective Antagonist ◽  
Melanin Concentrating Hormone

Cloning of a Novel G Protein-Coupled Receptor, SLT, a Subtype of the Melanin-Concentrating Hormone Receptor

2001 ◽  
Vol 283 (5) ◽  
pp. 1013-1018 ◽  
Author(s):  
Masaaki Mori ◽  
Mioko Harada ◽  
Yasuko Terao ◽  
Tsukasa Sugo ◽  
Takuya Watanabe ◽  
...  
Keyword(s):  
G Protein ◽  
Hormone Receptor ◽  
G Protein Coupled Receptor ◽  
Melanin Concentrating Hormone ◽  
G Protein Coupled
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