Gfi1‐GCE inducible Cre line for hair cell‐specific gene manipulation in mouse inner ear

genesis ◽  
2019 ◽  
Vol 57 (9) ◽  
Author(s):  
Qi Tang ◽  
Mei Xu ◽  
Jiadong Xu ◽  
Xiaoling Xie ◽  
Hua Yang ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Specific Gene ◽  
Gene Manipulation

scholarly journals Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion

genesis ◽  
2010 ◽  
Vol 48 (6) ◽  
pp. 400-406 ◽  
Author(s):  
Hua Yang ◽  
Jean Gan ◽  
Xiaoling Xie ◽  
Min Deng ◽  
Liang Feng ◽  
...  
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Gene Deletion ◽  
Specific Gene ◽  
Mouse Line

Hair cell regeneration in the inner ear

1994 ◽  
Vol 111 (3) ◽  
pp. 281-301 ◽  
Author(s):  
T TSUE ◽  
E OESTERLE ◽  
E RUBEL
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Cell Regeneration ◽  
Hair Cell Regeneration

Hair Cell Damage in the Inner Ear of the Guinea Pig Due to Noise in a Workshop

1987 ◽  
Vol 103 (5) ◽  
pp. 204-211 ◽  
Author(s):  
B. Erlandsson ◽  
H. Hakanson ◽  
A. Ivarsson ◽  
P. Nilsson ◽  
J. Wersall
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Inner Ear ◽  
Cell Damage ◽  
Hair Cell Damage

scholarly journals FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway

Autophagy ◽  
2021 ◽  
pp. 1-22
Author(s):  
Zu-Hong He ◽  
Ming Li ◽  
Qiao-Jun Fang ◽  
Fu-Ling Liao ◽  
Sheng-Yu Zou ◽  
...  
Keyword(s):  
Hair Cell ◽  
Cell Survival ◽  
Inner Ear ◽  
Autophagy Pathway

scholarly journals Cell of the month: An outer hair cell of the inner ear

2004 ◽  
Vol 6 (2) ◽  
pp. 96-96
Author(s):  
Mei Zhang ◽  
Patrick J. Antonelli
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Outer Hair Cell

Hes1 is a negative regulator of inner ear hair cell differentiation

Development ◽  
2000 ◽  
Vol 127 (21) ◽  
pp. 4551-4560 ◽  
Author(s):  
J.L. Zheng ◽  
J. Shou ◽  
F. Guillemot ◽  
R. Kageyama ◽  
W.Q. Gao
Keyword(s):  
Cell Differentiation ◽  
Hair Cell ◽  
Inner Ear ◽  
Cell Fate ◽  
Hair Cells ◽  
Outer Hair Cells ◽  
Negative Regulator ◽  
Pcr Analysis ◽  
Loss Of Function ◽  
Hair Cell Differentiation

Hair cell fate determination in the inner ear has been shown to be controlled by specific genes. Recent loss-of-function and gain-of-function experiments have demonstrated that Math1, a mouse homolog of the Drosophila gene atonal, is essential for the production of hair cells. To identify genes that may interact with Math1 and inhibit hair cell differentiation, we have focused on Hes1, a mammalian hairy and enhancer of split homolog, which is a negative regulator of neurogenesis. We report here that targeted deletion of Hes1 leads to formation of supernumerary hair cells in the cochlea and utricle of the inner ear. RT-PCR analysis shows that Hes1 is expressed in inner ear during hair cell differentiation and its expression is maintained in adulthood. In situ hybridization with late embryonic inner ear tissue reveals that Hes1 is expressed in supporting cells, but not hair cells, of the vestibular sensory epithelium. In the cochlea, Hes1 is selectively expressed in the greater epithelial ridge and lesser epithelial ridge regions which are adjacent to inner and outer hair cells. Co-transfection experiments in postnatal rat explant cultures show that overexpression of Hes1 prevents hair cell differentiation induced by Math1. Therefore Hes1 can negatively regulate hair cell differentiation by antagonizing Math1. These results suggest that a balance between Math1 and negative regulators such as Hes1 is crucial for the production of an appropriate number of inner ear hair cells.

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