scholarly journals Functional interaction between Foxd3 and Pax3 in cardiac neural crest development

genesis ◽  
2010 ◽  
Vol 49 (1) ◽  
pp. 10-23 ◽  
Author(s):  
Brian L. Nelms ◽  
Elise R. Pfaltzgraff ◽  
Patricia A. Labosky
Keyword(s):  
Neural Crest ◽  
Functional Interaction ◽  
Cardiac Neural Crest ◽  
Neural Crest Development

scholarly journals PlexinA2 and semaphorin signaling during cardiac neural crest development

Development ◽  
2001 ◽  
Vol 128 (16) ◽  
pp. 3071-3080 ◽  
Author(s):  
Christopher B. Brown ◽  
Leonard Feiner ◽  
Min-Min Lu ◽  
Jun Li ◽  
Xiaokui Ma ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neural Crest ◽  
Congenital Heart ◽  
Neural Crest Cells ◽  
Model Systems ◽  
Cardiac Neural Crest ◽  
Neural Crest Development ◽  
The Central Nervous System ◽  
Mouse Lines

Classic studies using avian model systems have demonstrated that cardiac neural crest cells are required for proper development of the cardiovascular system. Environmental influences that perturb neural crest development cause congenital heart defects in laboratory animals and in man. However, little progress has been made in determining molecular programs specifically regulating cardiac neural crest migration and function. Only recently have complex transgenic tools become available that confirm the presence of cardiac neural crest cells in the mammalian heart. These studies have relied upon the use of transgenic mouse lines and fate-mapping studies using Cre recombinase and neural crest-specific promoters. In this study, we use these techniques to demonstrate that PlexinA2 is expressed by migrating and postmigratory cardiac neural crest cells in the mouse. Plexins function as co-receptors for semaphorin signaling molecules and mediate axon pathfinding in the central nervous system. We demonstrate that PlexinA2-expressing cardiac neural crest cells are patterned abnormally in several mutant mouse lines with congenital heart disease including those lacking the secreted signaling molecule Semaphorin 3C. These data suggest a parallel between the function of semaphorin signaling in the central nervous system and in the patterning of cardiac neural crest in the periphery.

Msx2is an immediate downstream effector ofPax3in the development of the murine cardiac neural crest

Development ◽  
2002 ◽  
Vol 129 (2) ◽  
pp. 527-538 ◽  
Author(s):  
Stanford J. Kwang ◽  
Sean M. Brugger ◽  
Arthur Lazik ◽  
Amy E. Merrill ◽  
Lan-Ying Wu ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cardiac Development ◽  
Homeobox Gene ◽  
Bmp Signaling ◽  
Gene Migration ◽  
Cardiac Neural Crest ◽  
Molecular Approaches ◽  
Pax3 Gene ◽  
Downstream Effector ◽  
Neural Crest Development

The neural crest plays a crucial part in cardiac development. Cells of the cardiac subpopulation of cranial neural crest migrate from the hindbrain into the outflow tract of the heart where they contribute to the septum that divides the pulmonary and aortic channels. In Splotch mutant mice, which lack a functional Pax3 gene, migration of cardiac neural crest is deficient and aorticopulmonary septation does not occur. Downstream genes through which Pax3 regulates cardiac neural crest development are unknown. Here, using a combination of genetic and molecular approaches, we show that the deficiency of cardiac neural crest development in the Splotch mutant is caused by upregulation of Msx2, a homeobox gene with a well-documented role as a regulator of BMP signaling. We provide evidence, moreover, that Pax3 represses Msx2 expression via a direct effect on a conserved Pax3 binding site in the Msx2 promoter. These results establish Msx2 as an effector of Pax3 in cardiac neural crest development.

scholarly journals Meis2 is essential for cranial and cardiac neural crest development

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Ondrej Machon ◽  
Jan Masek ◽  
Olga Machonova ◽  
Stefan Krauss ◽  
Zbynek Kozmik
Keyword(s):  
Neural Crest ◽  
Cardiac Neural Crest ◽  
Neural Crest Development

scholarly journals The methyltransferase NSD3 regulates neural crest development

2011 ◽  
Vol 356 (1) ◽  
pp. 196
Author(s):  
Bridget Jacques-Fricke ◽  
Laura S. Gammill
Keyword(s):  
Neural Crest ◽  
Neural Crest Development
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