Peri-implantation lethality in mice lacking the PGC-1-related coactivator protein

2012 ◽  
Vol 241 (5) ◽  
pp. 975-983 ◽  
Author(s):  
Xin He ◽  
Chen Sun ◽  
Feng Wang ◽  
Aijing Shan ◽  
Ting Guo ◽  
...  
Keyword(s):  
Coactivator Protein

scholarly journals Polo kinase controls cell-cycle-dependent transcription by targeting a coactivator protein

Nature ◽  
2006 ◽  
Vol 444 (7118) ◽  
pp. 494-498 ◽  
Author(s):  
Zoulfia Darieva ◽  
Richard Bulmer ◽  
Aline Pic-Taylor ◽  
Kathryn S. Doris ◽  
Marco Geymonat ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Polo Kinase ◽  
Coactivator Protein ◽  
Cycle Dependent

scholarly journals Control of Amino Acid Homeostasis by a Ubiquitin Ligase-Coactivator Protein Complex

2017 ◽  
Vol 292 (9) ◽  
pp. 3827-3840 ◽  
Author(s):  
Damian Guerra ◽  
Sonia M. Chapiro ◽  
Réjane Pratelli ◽  
Shi Yu ◽  
Weitao Jia ◽  
...  
Keyword(s):  
Amino Acid ◽  
Ubiquitin Ligase ◽  
Protein Complex ◽  
Coactivator Protein ◽  
Amino Acid Homeostasis

scholarly journals Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes

FEBS Journal ◽  
2016 ◽  
Vol 283 (6) ◽  
pp. 968-985 ◽  
Author(s):  
Karthigeyan Dhanasekaran ◽  
Sujata Kumari ◽  
Ramachandran Boopathi ◽  
Hiroki Shima ◽  
Amrutha Swaminathan ◽  
...  
Keyword(s):  
Transcriptional Coactivator ◽  
Aurora Kinases ◽  
Coactivator Protein

scholarly journals Isolation and Characterization of a Novel Coactivator Protein, NCoA-62, Involved in Vitamin D-mediated Transcription

1998 ◽  
Vol 273 (26) ◽  
pp. 16434-16441 ◽  
Author(s):  
Troy A. Baudino ◽  
Dennis M. Kraichely ◽  
Stephen C. Jefcoat ◽  
Sandra K. Winchester ◽  
Nicola C. Partridge ◽  
...  
Keyword(s):  
Vitamin D ◽  
Isolation And Characterization ◽  
Coactivator Protein

scholarly journals The t(11;16)(q23;p13) Translocation in Myelodysplastic Syndrome Fuses the MLL Gene to the CBP Gene

Blood ◽  
1997 ◽  
Vol 89 (11) ◽  
pp. 3945-3950 ◽  
Author(s):  
Tomohiko Taki ◽  
Masahiro Sako ◽  
Masahiro Tsuchida ◽  
Yasuhide Hayashi
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myelodysplastic Syndrome ◽  
Myeloid Leukemia ◽  
Dna Methyltransferase ◽  
Creb Binding Protein ◽  
Mll Gene ◽  
Recurrent Translocation ◽  
Coactivator Protein ◽  
11Q23 Abnormalities ◽  
Acute Myeloid

Abstract The recurrent translocation t(11; 16)(q23; p13) has been reported to be associated with therapy-related acute leukemia. The MLL gene involved in other 11q23 abnormalities was also rearranged by this translocation. We analyzed two patients with myelodysplastic syndrome with t(11; 16) and showed that the MLL gene on 11q23 was fused with CREB-binding protein (CBP) gene on 16p13 in these patients. The CBP gene encodes a transcriptional adaptor/coactivator protein and it is mutated in patients with Rubinstein-Taybi syndrome. The CBP gene is also involved in acute myeloid leukemia (AML) with t(8; 16)(p11; p13). In-frame MLL-CBP fusion transcripts combine the MLL AT-hook motifs and DNA methyltransferase homology region with a largely intact CBP. Our results combined with the finding of the MOZ-CBP fusion in t(8; 16)-AML suggest that the CBP gene may be associated with leukemogenesis through translocations.

scholarly journals Inhibition of p300/CBP by Early B-Cell Factor

2003 ◽  
Vol 23 (11) ◽  
pp. 3837-3846 ◽  
Author(s):  
Fang Zhao ◽  
Ruth McCarrick-Walmsley ◽  
Peter Åkerblad ◽  
Mikael Sigvardsson ◽  
Tom Kadesch
Keyword(s):  
B Cell ◽  
Transcriptional Activation ◽  
Cell Receptor ◽  
B Cell Development ◽  
Promoter Activation ◽  
Homeodomain Proteins ◽  
Coactivator Protein ◽  
Early B Cell Factor

ABSTRACT Early B-cell factor (EBF) is a DNA binding protein required for early B-cell development. It activates transcription of several B-cell-specific genes, including the λ5 gene, which encodes a protein necessary for signaling by the pre-B-cell receptor. In an effort to understand the mechanism by which EBF activates transcription, we examined its interaction with the coactivator protein p300/CBP. We found that two domains of EBF each bind the histone acetyltransferase (HAT)/CH3 domain of p300/CBP both in vitro and in vivo. Surprisingly, transcriptional activation by EBF was not sensitive to E1A, a potent p300/CBP inhibitor. In fact, overexpressed EBF mimicked E1A by severely repressing the activity of several other transcription factors, including E47, a protein that acts cooperatively with EBF to promote transcription of the λ5 gene. This broad inhibitory profile correlated with EBF's ability to repress the HAT activity of p300/CBP in vivo and in vitro. However, such a repressed complex is not likely to form at the λ5 promoter in vivo since (i) EBF could not bind p300/CBP and DNA simultaneously and (ii) the cooperativity imparted by E47 was sensitive to E1A. Our data reveal an intriguing inhibitory property of EBF—a property shared only by E1A, Twist, Pu.1, and the Hox family of homeodomain proteins—and suggest that E47 and EBF play distinct roles during λ5 promoter activation.

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