scholarly journals Multifunctional human transcriptional coactivator protein PC4 is a substrate of Aurora kinases and activates the Aurora enzymes

FEBS Journal ◽  
2016 ◽  
Vol 283 (6) ◽  
pp. 968-985 ◽  
Author(s):  
Karthigeyan Dhanasekaran ◽  
Sujata Kumari ◽  
Ramachandran Boopathi ◽  
Hiroki Shima ◽  
Amrutha Swaminathan ◽  
...  
Keyword(s):  
Transcriptional Coactivator ◽  
Aurora Kinases ◽  
Coactivator Protein

scholarly journals Transcriptional Coactivator Protein p300

2001 ◽  
Vol 276 (36) ◽  
pp. 33721-33729 ◽  
Author(s):  
Paul R. Thompson ◽  
Hisanori Kurooka ◽  
Yoshihiro Nakatani ◽  
Philip A. Cole
Keyword(s):  
Transcriptional Coactivator ◽  
Coactivator Protein

scholarly journals Polyomavirus Large T Antigen Binds the Transcriptional Coactivator Protein p300

1999 ◽  
Vol 73 (2) ◽  
pp. 1734-1739 ◽  
Author(s):  
Maria Nemethova ◽  
Erhard Wintersberger
Keyword(s):  
Viral Protein ◽  
Histone Acetyltransferase ◽  
T Antigen ◽  
Binding Motif ◽  
Large T Antigen ◽  
Transcriptional Coactivator ◽  
Coactivator Protein ◽  
Histone Acetyltransferase Activity

ABSTRACT Using coimmunoprecipitation and glutathioneS-transferase pulldown experiments, we found that polyomavirus large T antigen binds to p300 in vivo and in vitro. The N-terminal region of the viral protein, including the pRB binding motif, was dispensable for this interaction, which involved several regions within the C-terminal half of the large T antigen. Interestingly, anti-T antibody coimmunoprecipitated a subspecies of p300 which has high histone acetyltransferase activity.

Aurora Kinase Inhibitors in Head and Neck Cancer

2018 ◽  
Vol 18 (3) ◽  
pp. 199-213
Author(s):  
Guangying Qi ◽  
Jing Liu ◽  
Sisi Mi ◽  
Takaaki Tsunematsu ◽  
Shengjian Jin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Cancer Therapy ◽  
Kinase Inhibitors ◽  
Biological Function ◽  
Aurora Kinase ◽  
Aurora Kinases ◽  
Related Research ◽  
Chemotherapy Drugs ◽  
Aurora Kinase Inhibitors

Aurora kinases are a group of serine/threonine kinases responsible for the regulation of mitosis. In recent years, with the increase in Aurora kinase-related research, the important role of Aurora kinases in tumorigenesis has been gradually recognized. Aurora kinases have been regarded as a new target for cancer therapy, resulting in the development of Aurora kinase inhibitors. The study and application of these small-molecule inhibitors, especially in combination with chemotherapy drugs, represent a new direction in cancer treatment. This paper reviews studies on Aurora kinases from recent years, including studies of their biological function, their relationship with tumor progression, and their inhibitors.

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