scholarly journals BMP-induced L-Maf regulates subsequent BMP-independent differentiation of primary lens fibre cells

2011 ◽  
Vol 240 (8) ◽  
pp. 1917-1928 ◽  
Author(s):  
Tanushree Pandit ◽  
Vijay K. Jidigam ◽  
Lena Gunhaga
Keyword(s):  
Lens Fibre

scholarly journals Biological glass: structural determinants of eye lens transparency

2011 ◽  
Vol 366 (1568) ◽  
pp. 1250-1264 ◽  
Author(s):  
Steven Bassnett ◽  
Yanrong Shi ◽  
Gijs F. J. M. Vrensen
Keyword(s):  
Refractive Index ◽  
Cellular Level ◽  
Structural Determinants ◽  
Lens Transparency ◽  
Index Matching ◽  
Lens Fibre ◽  
Refractive Index Matching ◽  
Lens Membranes ◽  
Adhesive Proteins ◽  
Structural Adaptations

The purpose of the lens is to project a sharply focused, undistorted image of the visual surround onto the neural retina. The first pre-requisite, therefore, is that the tissue should be transparent. Despite the presence of remarkably high levels of protein, the lens cytosol remains transparent as a result of short-range-order interactions between the proteins. At a cellular level, the programmed elimination of nuclei and other light-scattering organelles from cells located within the pupillary space contributes directly to tissue transparency. Scattering at the cell borders is minimized by the close apposition of lens fibre cells facilitated by a plethora of adhesive proteins, some expressed only in the lens. Similarly, refractive index matching between lens membranes and cytosol is believed to minimize scatter. Refractive index matching between the cytoplasm of adjacent cells is achieved through the formation of cellular fusions that allow the intermingling of proteins. Together, these structural adaptations serve to minimize light scatter and enable this living, cellular structure to function as ‘biological glass’.

Dissociation of lens fibre gap junctions releases MP70

1988 ◽  
Vol 91 (3) ◽  
pp. 415-421 ◽  
Author(s):  
J. Kistler ◽  
S. Bullivant
Keyword(s):  
Electron Microscope ◽  
Gap Junctions ◽  
Gap Junction ◽  
Plasma Membranes ◽  
Gradient Centrifugation ◽  
Membrane Structures ◽  
Treatment Results ◽  
Double Membrane ◽  
Lens Fibre ◽  
Junction Proteins

MIP and MP70 are putative gap junction components in the plasma membranes of the mammalian lens fibre cells. We show now that MP70 can be solubilized separately from MIP in mild detergent solutions, and that this treatment results in the dissociation of the fibre gap junctions. Solubilized MP70 was isolated as 16.9 S particles by velocity gradient centrifugation and in the electron microscope had the appearance of short double-membrane structures consistent with connexon-pairs. These observations open a new experimental avenue in which to characterize separately the two putative lens gap junction proteins structurally and functionally.

Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton

2004 ◽  
Vol 78 (1) ◽  
pp. 109-123 ◽  
Author(s):  
Aileen Sandilands ◽  
Xin Wang ◽  
Aileen M Hutcheson ◽  
John James ◽  
Alan R Prescott ◽  
...  
Keyword(s):  
Fibre Cell ◽  
Cell Cytoskeleton ◽  
Lens Fibre ◽  
Lens Fibre Cell

A lens fibre differentiation factor from calf neural retina

1986 ◽  
Vol 163 (2) ◽  
pp. 453-466 ◽  
Author(s):  
Mary T. Campbell ◽  
John W. McAvoy
Keyword(s):  
Neural Retina ◽  
Differentiation Factor ◽  
Lens Fibre

Core-index determination of a thick fibre using lens-fibre interference (LFI) technique

2004 ◽  
Vol 42 (2) ◽  
pp. 121-130 ◽  
Author(s):  
A.A. Hamza ◽  
M.A. Mabrouk ◽  
W.A. Ramadan ◽  
H.H. Wahba
Keyword(s):  
Lens Fibre ◽  
Thick Fibre

Polypeptides of the lens fibre cell intracellular matrix

1980 ◽  
Vol 36 (4) ◽  
pp. 416-418 ◽  
Author(s):  
M. Katar ◽  
W. -K. Lo ◽  
M. Nagpal ◽  
H. Maisel
Keyword(s):  
Fibre Cell ◽  
Lens Fibre ◽  
Lens Fibre Cell
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