scholarly journals BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

2008 ◽  
Vol 237 (11) ◽  
pp. 3200-3209 ◽  
Author(s):  
David J. McCulley ◽  
Ji-One Kang ◽  
James F. Martin ◽  
Brian L. Black
Keyword(s):  
Outflow Tract ◽  
Endocardial Cushion ◽  
Semilunar Valve ◽  
Valve Development ◽  
Heart Field ◽  
Anterior Heart Field

scholarly journals The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field

2005 ◽  
Vol 287 (1) ◽  
pp. 134-145 ◽  
Author(s):  
Michael P. Verzi ◽  
David J. McCulley ◽  
Sarah De Val ◽  
Evdokia Dodou ◽  
Brian L. Black
Keyword(s):  
Right Ventricle ◽  
Outflow Tract ◽  
Ventricular Septum ◽  
Expression Domain ◽  
Heart Field ◽  
The Right ◽  
Anterior Heart Field

scholarly journals Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development

Development ◽  
2007 ◽  
Vol 134 (8) ◽  
pp. 1593-1604 ◽  
Author(s):  
M. M. Goddeeris ◽  
R. Schwartz ◽  
J. Klingensmith ◽  
E. N. Meyers
Keyword(s):  
Neural Crest ◽  
Hedgehog Signaling ◽  
Neural Crest Cells ◽  
Outflow Tract ◽  
Heart Field ◽  
Anterior Heart Field

scholarly journals The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development

2012 ◽  
Vol 52 (5) ◽  
pp. 1096-1102 ◽  
Author(s):  
Chieh-Yu Lin ◽  
Chien-Jung Lin ◽  
Chen-Hao Chen ◽  
Richard M. Chen ◽  
Bin Zhou ◽  
...  
Keyword(s):  
Semilunar Valve ◽  
Valve Development ◽  
Heart Field ◽  
Secondary Heart Field

scholarly journals Outflow Tract Formation—Embryonic Origins of Conotruncal Congenital Heart Disease

2021 ◽  
Vol 8 (4) ◽  
pp. 42
Author(s):  
Sonia Stefanovic ◽  
Heather C. Etchevers ◽  
Stéphane Zaffran
Keyword(s):  
Congenital Heart ◽  
Cardiac Development ◽  
Heart Defects ◽  
Dynamic Structure ◽  
Cell Types ◽  
Outflow Tract ◽  
Heart Tube ◽  
Heart Field ◽  
Multiple Cell ◽  
The Many

Anomalies in the cardiac outflow tract (OFT) are among the most frequent congenital heart defects (CHDs). During embryogenesis, the cardiac OFT is a dynamic structure at the arterial pole of the heart. Heart tube elongation occurs by addition of cells from pharyngeal, splanchnic mesoderm to both ends. These progenitor cells, termed the second heart field (SHF), were first identified twenty years ago as essential to the growth of the forming heart tube and major contributors to the OFT. Perturbation of SHF development results in common forms of CHDs, including anomalies of the great arteries. OFT development also depends on paracrine interactions between multiple cell types, including myocardial, endocardial and neural crest lineages. In this publication, dedicated to Professor Andriana Gittenberger-De Groot and her contributions to the field of cardiac development and CHDs, we review some of her pioneering studies of OFT development with particular interest in the diverse origins of the many cell types that contribute to the OFT. We also discuss the clinical implications of selected key findings for our understanding of the etiology of CHDs and particularly OFT malformations.

scholarly journals Tbx1 regulates extracellular matrix-cell interactions in the second heart field

2019 ◽  
Vol 28 (14) ◽  
pp. 2295-2308 ◽  
Author(s):  
Daniela Alfano ◽  
Alessandra Altomonte ◽  
Claudio Cortes ◽  
Marchesa Bilio ◽  
Robert G Kelly ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cultured Cells ◽  
Time Window ◽  
Outflow Tract ◽  
Mouse Embryos ◽  
Cell Interactions ◽  
Deletion Syndrome ◽  
Cardiac Progenitors ◽  
Second Heart Field ◽  
Heart Field

Abstract Tbx1, the major candidate gene for DiGeorge or 22q11.2 deletion syndrome, is required for efficient incorporation of cardiac progenitors of the second heart field (SHF) into the heart. However, the mechanisms by which TBX1 regulates this process are still unclear. Here, we have used two independent models, mouse embryos and cultured cells, to define the role of TBX1 in establishing morphological and dynamic characteristics of SHF in the mouse. We found that loss of TBX1 impairs extracellular matrix (ECM)-integrin-focal adhesion (FA) signaling in both models. Mosaic analysis in embryos suggested that this function is non-cell autonomous, and, in cultured cells, loss of TBX1 impairs cell migration and FAs. Additionally, we found that ECM-mediated integrin signaling is disrupted upon loss of TBX1. Finally, we show that interfering with the ECM-integrin-FA axis between E8.5 and E9.5 in mouse embryos, corresponding to the time window within which TBX1 is required in the SHF, causes outflow tract dysmorphogenesis. Our results demonstrate that TBX1 is required to maintain the integrity of ECM-cell interactions in the SHF and that this interaction is critical for cardiac outflow tract development. More broadly, our data identifies a novel TBX1 downstream pathway as an important player in SHF tissue architecture and cardiac morphogenesis.

scholarly journals Hes1 Is Expressed in the Second Heart Field and Is Required for Outflow Tract Development

PLoS ONE ◽  
2009 ◽  
Vol 4 (7) ◽  
pp. e6267 ◽  
Author(s):  
Francesca Rochais ◽  
Mathieu Dandonneau ◽  
Karim Mesbah ◽  
Thérèse Jarry ◽  
Marie-Geneviève Mattei ◽  
...  
Keyword(s):  
Outflow Tract ◽  
Second Heart Field ◽  
Heart Field

scholarly journals Piezo1 is required for outflow tract and aortic valve development.

2020 ◽  
Vol 143 ◽  
pp. 51-62 ◽  
Author(s):  
Adèle Faucherre ◽  
Hamid Moha ou Maati ◽  
Nathalie Nasr ◽  
Amélie Pinard ◽  
Alexis Theron ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Outflow Tract ◽  
Valve Development

scholarly journals Myocardium at the base of the aorta and pulmonary trunk is prefigured in the outflow tract of the heart and in subdomains of the second heart field

2008 ◽  
Vol 313 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Fanny Bajolle ◽  
Stéphane Zaffran ◽  
Sigolène M. Meilhac ◽  
Mathieu Dandonneau ◽  
Ted Chang ◽  
...  
Keyword(s):  
Outflow Tract ◽  
Pulmonary Trunk ◽  
Second Heart Field ◽  
Heart Field
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