scholarly journals Zac1 promotes a Müller glial cell fate and interferes with retinal ganglion cell differentiation inXenopus retina

2006 ◽  
Vol 236 (1) ◽  
pp. 192-202 ◽  
Author(s):  
Lin Ma ◽  
Jennifer C. Hocking ◽  
Carrie L. Hehr ◽  
Carol Schuurmans ◽  
Sarah McFarlane
Keyword(s):  
Cell Differentiation ◽  
Ganglion Cell ◽  
Glial Cell ◽  
Cell Fate ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Müller Glial Cell

scholarly journals Protection by an Oral Disubstituted Hydroxylamine Derivative against Loss of Retinal Ganglion Cell Differentiation following Optic Nerve Crush

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e65966 ◽  
Author(s):  
James D. Lindsey ◽  
Karen X. Duong-Polk ◽  
Yi Dai ◽  
Duy H. Nguyen ◽  
Christopher K. Leung ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Hydroxylamine Derivative

scholarly journals Retinal Stem Cells Transplanted into Models of Late Stages of Retinitis Pigmentosa Preferentially Adopt a Glial or a Retinal Ganglion Cell Fate

2007 ◽  
Vol 48 (1) ◽  
pp. 446 ◽  
Author(s):  
Kriss Canola ◽  
Brigitte Ange´nieux ◽  
Meriem Tekaya ◽  
Alexander Quiambao ◽  
Muna I. Naash ◽  
...  
Keyword(s):  
Stem Cells ◽  
Retinitis Pigmentosa ◽  
Ganglion Cell ◽  
Cell Fate ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Late Stages ◽  
Retinal Stem Cells

scholarly journals Methods of Retinal Ganglion Cell Differentiation From Pluripotent Stem Cells

2014 ◽  
Vol 3 (3) ◽  
pp. 7 ◽  
Author(s):  
Katherine P. Gill ◽  
Alex W. Hewitt ◽  
Kathryn C. Davidson ◽  
Alice Pébay ◽  
Raymond C. B. Wong
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Pluripotent Stem Cells ◽  
Retinal Ganglion

Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth

Development ◽  
2002 ◽  
Vol 129 (2) ◽  
pp. 467-477 ◽  
Author(s):  
Steven W. Wang ◽  
Xiuqian Mu ◽  
William J. Bowers ◽  
Dong-Seob Kim ◽  
Daniel J. Plas ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Ganglion Cell ◽  
Retinal Ganglion Cells ◽  
Retinal Ganglion Cell ◽  
Knockout Mice ◽  
Ganglion Cells ◽  
Axon Outgrowth ◽  
Retinal Ganglion ◽  
Double Knockout ◽  
Ganglion Cell Axon

In mice, Brn3 POU domain transcription factors play essential roles in the differentiation and survival of projection neurons within the retina, inner ear, dorsal root and trigeminal ganglia. During retinal ganglion cell differentiation, Brn3b is expressed first, followed by Brn3a and Brn3c. Targeted deletion of Brn3b, but not Brn3a or Brn3c, leads to a loss of most retinal ganglion cells before birth. However, as a few retinal ganglion cells are still present in Brn3b–/– mice, Brn3a and Brn3c may partially compensate for the loss of Brn3b. To examine the role of Brn3c in retinal ganglion cell development, we generated Brn3b/Brn3c double knockout mice and analyzed their retinas and optic chiasms. Retinal ganglion cell axons from double knockout mice were more severely affected than were those from Brn3b-deficient mice, indicating that Brn3c was required for retinal ganglion cell differentiation and could partially compensate for the loss of Brn3b. Moreover, Brn3c had functions in retinal ganglion cell differentiation separate from those of Brn3b. Ipsilateral and misrouted projections at the optic chiasm were overproduced in Brn3b–/– mice but missing were entirely in optic chiasms of Brn3b/Brn3c double knockout mice, suggesting that Brn3c controlled ipsilateral axon production. Forced expression of Brn3c in Brn3b–/– retinal explants restored neurite outgrowth, demonstrating that Brn3c could promote axon outgrowth in the absence of Brn3b. Our results reveal a complex genetic relationship between Brn3b and Brn3c in regulating the retinal ganglion cell axon outgrowth.

Methods of Retinal Ganglion Cell Differentiation From Pluripotent Stem Cells

2014 ◽  
Vol 3 (4) ◽  
pp. 2 ◽  
Author(s):  
Katherine P. Gill ◽  
Alex W. Hewitt ◽  
Kathryn C. Davidson ◽  
Alice Pébay ◽  
Raymond C. B. Wong
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Pluripotent Stem Cells ◽  
Retinal Ganglion

Retinal growth hormone is an anti-apoptotic factor in embryonic retinal ganglion cell differentiation

2005 ◽  
Vol 81 (5) ◽  
pp. 551-560 ◽  
Author(s):  
Esmond J. Sanders ◽  
Eve Parker ◽  
Carlos Arámburo ◽  
Steve Harvey
Keyword(s):  
Growth Hormone ◽  
Cell Differentiation ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Retinal Growth
Sign in / Sign up

Export Citation Format

Share Document