Identification of S22 (ostarine) in human nails and hair using LC‐HRMS. Application to two authentic cases

2020 ◽  
Vol 12 (10) ◽  
pp. 1508-1513 ◽  
Author(s):  
Pascal Kintz ◽  
Laurie Gheddar ◽  
Alice Ameline ◽  
Jean‐Sébastien Raul
Keyword(s):  
Human Nails

scholarly journals Characterization of a biofilm formed by Fusarium oxysporum on the human nails

2021 ◽  
Author(s):  
Flavia Franco Veiga ◽  
Lidiane Vizioli Castro‐Hoshino ◽  
Francielle Sato ◽  
Mauro Luciano Baesso ◽  
Sónia Silva ◽  
...  
Keyword(s):  
Fusarium Oxysporum ◽  
Human Nails

scholarly journals Human Nails Permeation of an Antifungal Candidate Hydroalcoholic Extract from the Plant Sapindus saponaria L. Rich in Saponins

Molecules ◽  
2021 ◽  
Vol 26 (1) ◽  
pp. 236
Author(s):  
Vanessa Mendes ◽  
Flávia Franco Veiga ◽  
Lidiane Vizioli de Castro-Hoshino ◽  
Francielle Sato ◽  
Mauro Luciano Baesso ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Attenuated Total Reflection ◽  
Ionization Mass ◽  
Healthy Human ◽  
Hydroalcoholic Extract ◽  
Sapindus Saponaria ◽  
Infrared Spectrometer ◽  
Low Cytotoxicity ◽  
Human Nails

We evaluated a hydroalcoholic extract of Sapindus saponaria L. pericarps (ETHOSS), as a candidate to a topical antifungal medicine for onychomycosis. ETHOSS was produced by extracting the crushed fruits in ethanol. The saponin contents were identified and characterized by electrospray ionization mass spectrometry. We measured the in vitro antifungal activity against three dermatophyte fungi, isolated from onychomycosis: Trichophyton rubrum, T. mentagrophytes, and T. interdigitale, using broth microdilution tests. The minimum fungicide concentration of ETHOSS ranged from 195.31 to 781.25 μg/mL. The cytotoxicity of the crude extract was tested on the HeLa cell line, and its ability to permeate into healthy human nails by photoacoustic spectroscopy and Fourier transformation infrared spectrometer (FTIR) spectroscopy by attenuated total reflection. Besides its strong antifungal activity, ETHOSS showed low cytotoxicity in human cells. It was able to permeate and reach the full thickness of the nail in one hour, without the aid of facilitating vehicles, and remained there for at least 24 h. These results suggest that ETHOSS has great potential for treating onychomycosis.

Eurotium rubrum. [Descriptions of Fungi and Bacteria].

1995 ◽  
Author(s):  
Z. Kozakiewicz
Keyword(s):  
Host Range ◽  
Geographical Distribution ◽  
World Wide ◽  
Human Nails

Abstract A description is provided for Eurotium rubrum. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: A xerotolerant species with the same host range as E. repens (IMI Sheet 1255). DISEASES: Not known to be a pathogen of animals or man, but the species has been isolated from human nails (Smith, 1989). GEOGRAPHICAL DISTRIBUTION: World-wide.

scholarly journals The use of the Er:YAG 2940nm laser associated with amorolfine lacquer in the treatment of onychomycosis

2013 ◽  
Vol 88 (5) ◽  
pp. 847-849 ◽  
Author(s):  
Orlando Oliveira de Morais ◽  
Izelda Maria Carvalho Costa ◽  
Ciro Martins Gomes ◽  
Dayane Higa Shinzato ◽  
Guilherme Marreta Cavalcanti Ayres ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Topical Treatment ◽  
Er:Yag Laser ◽  
Nail Plate ◽  
Common Disease ◽  
Human Nails

Onychomycosis is a common disease, accounting for up to 50% of all ungual pathologies. We have been developing a clinical trial (ClinicalTrials.gov: NCT01528813) using a 2940nm Er:YAG laser to fractionally ablate human nails in vivo, aiming to increase topical amorolfine lacquer delivery to the nail unit, increasing the efficacy of topical treatment of distal and lateral subungual onychomycosis. Partial results have shown an increase in areas of nail plate free of disease. We believe that ablative lasers can increase the efficacy of topical onychomycosis treatment.

Influence of nails polish in EPR dosimetry with human nails

2015 ◽  
Vol 75 ◽  
pp. 6-8 ◽  
Author(s):  
François Trompier ◽  
Alexander Romanyukha ◽  
Steven Swarts ◽  
Ricardo Reyes ◽  
Didier Gourier
Keyword(s):  
Epr Dosimetry ◽  
Human Nails

Determination of iodine in human nails via epithermal neutron activation analysis

1995 ◽  
Vol 195 (1) ◽  
pp. 21-30 ◽  
Author(s):  
V. L. Spate ◽  
J. S. Morris ◽  
S. Chickos ◽  
C. K. Baskett ◽  
M. M. Mason ◽  
...  
Keyword(s):  
Neutron Activation Analysis ◽  
Activation Analysis ◽  
Neutron Activation ◽  
Epithermal Neutron ◽  
Epithermal Neutron Activation Analysis ◽  
Human Nails

scholarly journals ACTIVATION ANALYSIS OF TRACE ELEMENTS IN HUMAN NAILS : (1)SULFUR, PHOSPHORUS AND CHLORINE

Sangyo Igaku ◽  
1968 ◽  
Vol 10 (5) ◽  
pp. 285-288 ◽  
Author(s):  
Yoshio SHINBORI ◽  
Takeichiro INOUE
Keyword(s):  
Trace Elements ◽  
Activation Analysis ◽  
Human Nails
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