scholarly journals Pilot study on the effects of intravesical oxybutynin hydrochloride instillations on the validity of doping control urine samples

2019 ◽  
Vol 11 (11-12) ◽  
pp. 1755-1760 ◽  
Author(s):  
Katja Walpurgis ◽  
Anja B. Scheiff ◽  
Meike Welz ◽  
Jutta Müller‐Reul ◽  
Nick Webborn ◽  
...  
Keyword(s):  
Pilot Study ◽  
Doping Control ◽  
Urine Samples ◽  
Oxybutynin Hydrochloride

Quantifying cobalt in doping control urine samples - a pilot study

2014 ◽  
Vol 6 (11-12) ◽  
pp. 1186-1190 ◽  
Author(s):  
Oliver Krug ◽  
Daniel Kutscher ◽  
Thomas Piper ◽  
Hans Geyer ◽  
Wilhelm Schänzer ◽  
...  
Keyword(s):  
Pilot Study ◽  
Doping Control ◽  
Urine Samples ◽  
In Doping

Determination of cannabinoids in oral fluid and urine of “light cannabis” consumers: a pilot study

2018 ◽  
Vol 57 (2) ◽  
pp. 238-243 ◽  
Author(s):  
Roberta Pacifici ◽  
Simona Pichini ◽  
Manuela Pellegrini ◽  
Roberta Tittarelli ◽  
Flaminia Pantano ◽  
...  
Keyword(s):  
Pilot Study ◽  
Oral Fluid ◽  
Urine Samples ◽  
Screening Tests ◽  
Gas Chromatography Mass Spectrometry ◽  
Negative Results ◽  
A Value ◽  
Order Of Magnitude ◽  
Confirmation Analysis

Abstract Background In those countries where cannabis use is still illegal, some manufacturers started producing and selling “light cannabis”: dried flowering tops containing the psychoactive principle Δ-9-tetrahydrocannabinol (THC) at concentrations lower than 0.2% together with variable concentration of cannabidiol (CBD). We here report a pilot study on the determination of cannabinoids in the oral fluid and urine of six individuals after smoking 1 g of “light cannabis”. Methods On site screening for oral fluid samples was performed, as a laboratory immunoassay test for urine samples. A validated gas chromatography-mass spectrometry (GC-MS) method was then applied to quantify THC and CBD, independently from results of screening tests. Results On site screening for oral fluid samples, with a THC cut-off of 25 ng/mL gave negative results for all the individuals at different times after smoking. Similarly, negative results for urine samples screening from all the individuals were obtained. Confirmation analyses showed that oral fluid THC was in the concentration range from 2.5 to 21.5 ng/mL in the first 30 min after smoking and then values slowly decreased. CBD values were usually one order of magnitude higher than those of THC. THC-COOH, the principal urinary THC metabolite, presented the maximum urinary value of 1.8 ng/mL, while urinary CBD had a value of 15.1 ng/mL. Conclusions Consumers of a single 1 g dose of “light cannabis” did not result as positive in urine screening, assessing recent consumption, so that confirmation would not be required. Conversely, they might result as positive to oral fluid testing with some on-site kits, with THC cut-off lower than 25 ng/mL, at least in the first hour after smoking and hence confirmation analysis can be then required. No conclusions can be drawn of eventual chronic users.

scholarly journals Investigating the dynamics of Leishmania antigen in the urine of patients with visceral leishmaniasis: a pilot study

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1514
Author(s):  
Prakash Ghosh ◽  
Israel Cruz ◽  
Albert Picado ◽  
Thomas Edwards ◽  
Md. Anik Ashfaq Khan ◽  
...  
Keyword(s):  
Pilot Study ◽  
Visceral Leishmaniasis ◽  
Treatment Monitoring ◽  
Urine Samples ◽  
Urinary Antigen ◽  
Antigen Concentration ◽  
Elisa Kit ◽  
Time Points ◽  
Non Invasive ◽  
Antigen Elisa

Background: Detection of Leishmania antigens in the urine provides a non-invasive means of diagnosis and treatment monitoring of cases of visceral leishmaniasis (VL). Leishmania antigen load in the urine may vary between different time-points within a day, thus influencing the performance of antigen-detection tests. Methods: We investigated the dynamics of Leishmania antigen in urine collected at three different time points (08:00, 12:00 and 16:00 hours). All urine samples collected were tested with the Leishmania Antigen ELISA (VL ELISA) kit, produced by Kalon Biological Ltd., UK. Results: The median concentration of Leishmania antigen in urine collected at 08:00 (2.7 UAU-urinary antigen units/ml) was higher than at 12:00 (1.7 UAU/ml) and at 16:00 (1.9 UAU/ml). These differences were found to be statistically significant (08:00 vs. 12:00, p=0.011; 08:00 vs. 16:00, p=0.041). Conclusion: This pilot study indicates that the Leishmania antigen concentration is higher in urine samples collected in the morning, which has important implications when the VL ELISA kit or other tests to detect Leishmania antigen in urine are used for diagnosis of VL and treatment monitoring.

scholarly journals Correlates of Nine-Month Retention following Interim Buprenorphine-Naloxone Treatment in Opioid Dependence: A Pilot Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
A. Håkansson ◽  
C. Widinghoff ◽  
T. Abrahamsson ◽  
C. Gedeon
Keyword(s):  
Pilot Study ◽  
Opioid Dependence ◽  
Pilot Trial ◽  
Treatment Phase ◽  
Full Scale ◽  
Urine Samples ◽  
Interim Phase ◽  
Other Substances ◽  
Baseline Characteristics ◽  
Naloxone Treatment

Interim medication-only treatment has been suggested for the initiation of opioid maintenance treatment (OMT) in opioid-dependent subjects, but this rarely has been studied using buprenorphine instead of methadone. Following a pilot trial assessing interim buprenorphine-naloxone treatment in order to facilitate transfer into OMT, we here aimed to study retention, and potential correlates of retention, in full-scale treatment. Thirty-six patients successfully referred from a waiting list through an interim treatment phase were followed for nine months in OMT. Baseline characteristics, as well as urine analyses during the interim phase and during full-scale OMT, were studied as potential correlates of retention. The nine-month retention in OMT was 83 percent (n=30). While interim-phase urine samples positive for benzodiazepines did not significantly predict dropout from full-scale OMT (p=0.09), urine samples positive for benzodiazepines within full-scale OMT were significantly associated with dropout (p<0.01), in contrast to other substances and baseline characteristics. Retention remained high through nine months in this pilot study sample of patients referred through buprenorphine-naloxone interim treatment, but use of benzodiazepines is problematic, and the present data suggest that it may be associated with treatment dropout.

Reference materials for analytical toxicology including doping control: freeze-dried urine samples

The Analyst ◽  
2004 ◽  
Vol 129 (5) ◽  
pp. 449-455 ◽  
Author(s):  
C. Jiménez ◽  
R. Ventura ◽  
J. Williams ◽  
J. Segura ◽  
R. de la Torre
Keyword(s):  
Reference Materials ◽  
Doping Control ◽  
Urine Samples ◽  
Analytical Toxicology ◽  
Freeze Dried

Bisphenol-A and phthalates contamination of urine samples by catheters in the Elfe pilot study: Implications for large-scale biomonitoring studies

2011 ◽  
Vol 111 (6) ◽  
pp. 761-764 ◽  
Author(s):  
Stephanie Vandentorren ◽  
Florence Zeman ◽  
Lise Morin ◽  
Hélène Sarter ◽  
Marie-Laure Bidondo ◽  
...  
Keyword(s):  
Pilot Study ◽  
Bisphenol A ◽  
Large Scale ◽  
Urine Samples

scholarly journals PROM and Labour Effects on Urinary Metabolome: A Pilot Study

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Alessandra Meloni ◽  
Francesco Palmas ◽  
Luigi Barberini ◽  
Rossella Mereu ◽  
Sara Francesca Deiana ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Pilot Study ◽  
Multivariate Statistical Analysis ◽  
Adverse Outcomes ◽  
Urine Samples ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Multivariate Statistical ◽  
Clinical Conditions ◽  
In Pregnancy

Since pathologies and complications occurring during pregnancy and/or during labour may cause adverse outcomes for both newborns and mothers, there is a growing interest in metabolomic applications on pregnancy investigation. In fact, metabolomics has proved to be an efficient strategy for the description of several perinatal conditions. In particular, this study focuses on premature rupture of membranes (PROM) in pregnancy at term. For this project, urine samples were collected at three different clinical conditions: out of labour before PROM occurrence (Ph1), out of labour with PROM (Ph2), and during labour with PROM (Ph3). GC-MS analysis, followed by univariate and multivariate statistical analysis, was able to discriminate among the different classes, highlighting the metabolites most involved in the discrimination.

scholarly journals Exceptional circumstances beyond International Swimming Federation Doping Control Rules: The Sun Yang case of Court of Arbitration for Sport

2021 ◽  
Vol 12 (1) ◽  
pp. 131-143
Author(s):  
Evgenia G. Vetrova ◽  
Raisa I. Khalatova ◽  
Anastasia A. Kashaeva
Keyword(s):  
Doping Control ◽  
Urine Samples ◽  
Control Procedure ◽  
The Sun ◽  
Destruction Process ◽  
Blood Samples ◽  
Urine Sampling ◽  
Control Rules ◽  
World Anti Doping Agency

The authors refer to the exceptional circumstances surrounding Sun Yang’s violation. The athlete intervened in the doping control procedure in several ways. First, he questioned the proper accreditation of the IDTM’s (The company “International Doping Tests and Management”) Samples Collection Personnel, one of which photographed him. This officer was suspended from urine sampling, but there was no longer a male specialist on the IDTM’s Samples Collection Personnel. Therefore, the collection of urine samples did not take place due to the athlete’s actions. A general distrust of IDTM’s Samples Collection Personnel due to inappropriate photographing was the catalyst for follow-up action. Secondly, the athlete required IDTM’s Samples Collection Personnel to confirm his credentials (accreditation) from the anti-doping organization, despite the submission of documents by IDTM’s Samples Collection Personnel following the International Standard for Testing and Investigations. Not having received the additional and, in the opinion of the athlete, necessary documents, he refused to participate in the doping control procedure as a whole, tearing up his previously given written consent. Finally, the athlete took part in the destruction of blood samples with a hammer, but his role in this process was controversial. A prerequisite for the destruction process of the samples was the assistance of the IDTM’s Samples Collection Personnel, who handed them over to the athlete in response to insistent demands. The listed circumstances, which are exceptional, however, could not affect the reduction of Sun Yang’s period of ineligibility, since the FINA (International Swimming Federation) Doping Control Rules, based on WADA (World Anti-Doping Agency) Code 2015, do not imply such a basis. The new WADA Code 2021 offers a more flexible concept of liability and takes into account exceptional circumstances that in subsequent disputes about tampering can be established based on the example of the dispute CAS 2019/A/6148.

Sign in / Sign up

Export Citation Format

Share Document