Identification of a thermal degradation product of CUMYL‐PEGACLONE and its detection in biological samples

2019 ◽  
Vol 11 (10) ◽  
pp. 1480-1485 ◽  
Author(s):  
Christine Nash ◽  
Linda Glowacki ◽  
Dimitri Gerostamoulos ◽  
Paul Pigou ◽  
Timothy Scott ◽  
...  
Keyword(s):  
Thermal Degradation ◽  
Biological Samples ◽  
Degradation Product ◽  
Thermal Degradation Product

Ionene: A Thermal Degradation Product of beta-Carotene

Science ◽  
1963 ◽  
Vol 141 (3583) ◽  
pp. 808-808 ◽  
Author(s):  
W. C. Day ◽  
J. G. Erdman
Keyword(s):  
Thermal Degradation ◽  
Degradation Product ◽  
Beta Carotene ◽  
Thermal Degradation Product

scholarly journals Interaction of Ochratoxin A and Its Thermal Degradation Product 2′R-Ochratoxin A with Human Serum Albumin

Toxins ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 256 ◽  
Author(s):  
Franziska Sueck ◽  
Miklós Poór ◽  
Zelma Faisal ◽  
Christoph Gertzen ◽  
Benedikt Cramer ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Thermal Degradation ◽  
Serum Albumin ◽  
Human Serum ◽  
Ochratoxin A ◽  
Degradation Product ◽  
Thermal Degradation Product

Detection of main metabolites of XLR-11 and its thermal degradation product in human hepatoma HepaRG cells and human urine

2015 ◽  
Vol 7 (4) ◽  
pp. 341-345 ◽  
Author(s):  
Tatsuyuki Kanamori ◽  
Koji Kanda ◽  
Tadashi Yamamuro ◽  
Kenji Kuwayama ◽  
Kenji Tsujikawa ◽  
...  
Keyword(s):  
Thermal Degradation ◽  
Human Urine ◽  
Degradation Product ◽  
Human Hepatoma ◽  
Heparg Cells ◽  
Thermal Degradation Product

Thermal degradation of organic material by portable laser Raman spectrometry

2012 ◽  
Vol 11 (3) ◽  
pp. 177-186 ◽  
Author(s):  
Sanjoy M. Som ◽  
Bernard H. Foing
Keyword(s):  
Thermal Degradation ◽  
Biological Samples ◽  
Signal To Noise Ratio ◽  
Power Level ◽  
Laser Wavelength ◽  
Planetary Exploration ◽  
Integration Time ◽  
Raman Spectrometry ◽  
Laser Raman ◽  
Higher Power

AbstractRaman spectrometry has been established as an instrument of choice for studying the structure and bond type of known molecules, and identifying the composition of unknown substances, whether geological or biological. This versatility has led to its strong consideration for planetary exploration. In the context of the ExoGeoLab and ExoHab pilot projects of ESA-ESTEC & ILEWG (International Lunar Exploration Working Group), we investigated samples of astrobiological interest using a portable Raman spectrometer lasing at 785 nm and discuss implications for planetary exploration. We find that biological samples are typically best observed at wavenumbers >1100 cm−1, but their Raman signals are often affected by fluorescence effects, which lowers their signal-to-noise ratio. Raman signals of minerals are typically found at wavenumbers <1100 cm−1, and tend to be less affected by fluorescence. While higher power and/or longer signal integration time improve Raman signals, such power settings are detrimental to biological samples due to sample thermal degradation. Care must be taken in selecting the laser wavelength, power level and integration time for unknown samples, particularly if Raman signatures of biological components are anticipated. We include in the Appendices tables of Raman signatures for astrobiologically relevant organic compounds and minerals.

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