scholarly journals Neurotensin and neurotensin receptor 1 mRNA expression in song-control regions changes during development in male zebra finches

2018 ◽  
Vol 78 (7) ◽  
pp. 671-686
Author(s):  
Devin P. Merullo ◽  
Chinweike N. Asogwa ◽  
Miguel Sanchez-Valpuesta ◽  
Shin Hayase ◽  
Bikash R. Pattnaik ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Zebra Finches ◽  
Neurotensin Receptor ◽  
Song Control ◽  
Neurotensin Receptor 1 ◽  
Control Regions

scholarly journals The expression of delta opioid receptor mRNA in adult male zebra finches (Taenopygia guttata)

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256599
Author(s):  
Pooja Parishar ◽  
Neha Sehgal ◽  
Soumya Iyengar
Keyword(s):  
Opioid Receptors ◽  
Sequence Similarity ◽  
Expression Patterns ◽  
Auditory Pathway ◽  
Zebra Finches ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
High Sequence Similarity ◽  
Brain Functions ◽  
Song Control

The endogenous opioid system is evolutionarily conserved across reptiles, birds and mammals and is known to modulate varied brain functions such as learning, memory, cognition and reward. To date, most of the behavioral and anatomical studies in songbirds have mainly focused on μ-opioid receptors (ORs). Expression patterns of δ-ORs in zebra finches, a well-studied species of songbird have not yet been reported, possibly due to the high sequence similarity amongst different opioid receptors. In the present study, a specific riboprobe against the δ-OR mRNA was used to perform fluorescence in situ hybridization (FISH) on sections from the male zebra finch brain. We found that δ-OR mRNA was expressed in different parts of the pallium, basal ganglia, cerebellum and the hippocampus. Amongst the song control and auditory nuclei, HVC (abbreviation used as a formal name) and NIf (nucleus interfacialis nidopallii) strongly express δ-OR mRNA and stand out from the surrounding nidopallium. Whereas the expression of δ-OR mRNA is moderate in LMAN (lateral magnocellular nucleus of the anterior nidopallium), it is low in the MSt (medial striatum), Area X, DLM (dorsolateral nucleus of the medial thalamus), RA (robust nucleus of the arcopallium) of the song control circuit and Field L, Ov (nucleus ovoidalis) and MLd (nucleus mesencephalicus lateralis, pars dorsalis) of the auditory pathway. Our results suggest that δ-ORs may be involved in modulating singing, song learning as well as spatial learning in zebra finches.

Evaluation of neurotensin receptor 1 as potential biomarker for prostate cancer theranostic use

2019 ◽  
Vol 46 (10) ◽  
pp. 2199-2207 ◽  
Author(s):  
Tingting He ◽  
Mengzhe Wang ◽  
Hui Wang ◽  
Hongpei Tan ◽  
Yongxiang Tang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Neurotensin Receptor ◽  
Potential Biomarker ◽  
Neurotensin Receptor 1

scholarly journals Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Julian Budzinski ◽  
Simone Maschauer ◽  
Hiroyuki Kobayashi ◽  
Pierre Couvineau ◽  
Hannah Vogt ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Receptor Interaction ◽  
Endosomal Trafficking ◽  
Receptor Ligands ◽  
Bivalent Ligands ◽  
Neurotensin Receptor ◽  
Neuropsychiatric Diseases ◽  
Dopamine D3 ◽  
Neurotensin Receptor 1 ◽  
G Protein Coupled

AbstractBivalent ligands are composed of two pharmacophores connected by a spacer of variable size. These ligands are able to simultaneously recognize two binding sites, for example in a G protein-coupled receptor heterodimer, resulting in enhanced binding affinity. Taking advantage of previously described heterobivalent dopamine-neurotensin receptor ligands, we demonstrate specific interactions between dopamine D3 (D3R) and neurotensin receptor 1 (NTSR1), two receptors with expression in overlapping brain areas that are associated with neuropsychiatric diseases and addiction. Bivalent ligand binding to D3R-NTSR1 dimers results in picomolar binding affinity and high selectivity compared to the binding to monomeric receptors. Specificity of the ligands for the D3R-NTSR1 receptor pair over D2R-NTSR1 dimers can be achieved by a careful choice of the linker length. Bivalent ligands enhance and stabilize the receptor-receptor interaction leading to NTSR1-controlled internalization of D3R into endosomes via recruitment of β-arrestin, highlighting a potential mechanism for dimer-specific receptor trafficking and signalling.

Neurotensin receptor 1 is a new therapeutic target for human undifferentiated pleomorphic sarcoma growth

2019 ◽  
Vol 58 (12) ◽  
pp. 2230-2240
Author(s):  
Hiroto Tokumoto ◽  
Takao Setoguchi ◽  
Yoshinobu Saitoh ◽  
Hiromi Sasaki ◽  
Satoshi Nagano ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Neurotensin Receptor ◽  
Pleomorphic Sarcoma ◽  
Neurotensin Receptor 1
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