Introduction to the special issue on neural stem cells: Regulation and function

2012 ◽  
Vol 72 (7) ◽  
pp. 953-954 ◽  
Author(s):  
Perry F. Bartlett ◽  
Benedikt Berninger
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Special Issue ◽  
And Function

Adult neural stem cells: fate and function

2006 ◽  
Vol 54 (5) ◽  
pp. 266-269 ◽  
Author(s):  
K. Murray ◽  
P.-M. Lledo
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Adult Neural Stem Cells ◽  
And Function

Expression and function of galectin-1 in adult neural stem cells

2007 ◽  
Vol 64 (10) ◽  
pp. 1254-1258 ◽  
Author(s):  
M. Sakaguchi ◽  
Y. Imaizumi ◽  
H. Okano
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Adult Neural Stem Cells ◽  
And Function

Expression and function of orphan nuclear receptor TLX in adult neural stem cells

Nature ◽  
2004 ◽  
Vol 427 (6969) ◽  
pp. 78-83 ◽  
Author(s):  
Yanhong Shi ◽  
D. Chichung Lie ◽  
Philippe Taupin ◽  
Kinichi Nakashima ◽  
Jasodhara Ray ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Nuclear Receptor ◽  
Orphan Nuclear Receptor ◽  
Adult Neural Stem Cells ◽  
And Function

scholarly journals Msps Governs Acentrosomal Microtubule Assembly and Reactivation of Quiescent Neural Stem Cells

2020 ◽  
Author(s):  
Qiannan Deng ◽  
Ye Sing Tan ◽  
Liang Yuh Chew ◽  
Hongyan Wang
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cell Body ◽  
Microtubule Assembly ◽  
Dependent Manner ◽  
Contact Points ◽  
A Cell ◽  
And Function ◽  
Cellular Protrusion ◽  
E Cadherin

SUMMARYThe ability of stem cells to switch between quiescence and proliferation is crucial for tissue homeostasis and regeneration. Drosophila quiescent neural stem cells (NSCs) extend a primary cellular protrusion from the cell body prior to their reactivation. However, the structure and function of this protrusion are not well established. In this study, we show that in the primary protrusion of quiescent NSCs microtubules are predominantly acentrosomal and oriented plus-end-out, distal to the cell body. We have identified Mini Spindles (Msps)/XMAP215 as a key regulator of NSC reactivation and acentrosomal microtubule assembly in quiescent NSCs. We show that E-cadherin, a cell adhesion molecule, is localized to NSC-neuropil contact points, in a Msps-dependent manner, and is intrinsically required for NSC reactivation. Our study demonstrates a novel mechanism by which Msps-dependent microtubule assembly in the primary protrusion of quiescent NSCs targets E-cadherin to NSC-neuropil contact sites to promote NSC reactivation. We propose that the neuropil functions as a new niche for promoting NSC reactivation, which may be a general paradigm in mammalian systems.

Neural stem cells: form and function

2002 ◽  
Vol 5 (5) ◽  
pp. 392-394 ◽  
Author(s):  
Thomas A. Reh
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Form And Function ◽  
And Function

scholarly journals Expression and function of Ndel1 during the differentiation of neural stem cells induced by hippocampal exosomes

2020 ◽  
Author(s):  
WEN LI ◽  
Shanshan Wang ◽  
Hui He ◽  
Jianbing Qin ◽  
Xiang Cheng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Flow Cytometry ◽  
Nervous System ◽  
Neural Stem Cells ◽  
Western Blot ◽  
Hippocampal Neurogenesis ◽  
Quiescent State ◽  
Nervous System Diseases ◽  
And Function

Abstract BackgroundIn the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capacity. Most neural stem cells are in a quiescent state, but in response to extrinsic stimuli, they can exit from quiescence and become reactivated to produce new neurons, so neural stem cells are considered to be a potential source for cell replacement therapy of many nervous system diseases. We characterized the expression of Ndel1 during the differentiation of neural stem cells induced by hippocampus exosomes, and assessed the effect of Ndel1 on neural stem cells differentiationMethodsHippocampal exosomes were isolated and extracted, and co-cultured exosomes with neural stem cells. Western blot, flow cytometry, and immunofluorescence analyses were used to analyze expression of neuronal markers. Further, utilizing high-throughput RNA sequencing technology, we found that nudE neurodevelopment protein 1-like 1 was significantly up-regulated in exosomes derived from denervated hippocampus, and then characterized its mechanism and function during neural stem cells differentiation by qRT-PCR, western blot, flow cytometry, and immunofluorescence analyses.ResultsOur results revealed that exosomes of denervated hippocampus promoted the differentiation of neural stem cells into neuron. Hence, we identified that nudE neurodevelopment protein 1-like 1 (Ndel1) was significantly up-regulated and highly expressed in the nervous system. In addition, we found that miR-107-3p may regulate NSCs differentiation by targeting Ndel1.ConclusionsOur results revealed that deafferentation of the hippocampal exosomes co-cultured with NSCs could promote them to differentiate into neurons. Hence, we found that miR-107-3p may regulate NSCs differentiation by targeting Ndel1. Importantly, Ndel1 enhanced spatial learning and hippocampal neurogenesis in rats after FF transection In vivo. These findings set the stage for a better understanding of neurogenesis, a process that one day may inspire new treatments for central nervous system diseases.

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