A fight for survival: The challenges faced by a newborn neuron integrating in the adult hippocampus

2012 ◽  
Vol 72 (7) ◽  
pp. 1016-1031 ◽  
Author(s):  
Matteo Bergami ◽  
Benedikt Berninger
Keyword(s):  
Newborn Neuron ◽  
Adult Hippocampus

Metabolic Regulation of Hippocampal Neuronal Development and Its Inhibition After Irradiation

2021 ◽  
Vol 80 (5) ◽  
pp. 467-475
Author(s):  
Yu-Qing Li ◽  
C Shun Wong
Keyword(s):  
Cell Fate ◽  
Metabolic Regulation ◽  
Energy Homeostasis ◽  
Neuronal Development ◽  
Adenosine Monophosphate ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Wild Type ◽  
Newborn Neuron ◽  
Negative Effect

Abstract 5′-Adenosine monophosphate-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis, plays a role in cell fate determination. Whether AMPK regulates hippocampal neuronal development remains unclear. Hippocampal neurogenesis is abrogated after DNA damage. Here, we asked whether AMPK regulates adult hippocampal neurogenesis and its inhibition following irradiation. Adult Cre-lox mice deficient in AMPK in brain, and wild-type mice were used in a birth-dating study using bromodeoxyuridine to evaluate hippocampal neurogenesis. There was no evidence of AMPK or phospho-AMPK immunoreactivity in hippocampus. Increase in p-AMPK but not AMPK expression was observed in granule neurons and subgranular neuroprogenitor cells (NPCs) in the dentate gyrus within 24 hours and persisted up to 9 weeks after irradiation. AMPK deficiency in Cre-lox mice did not alter neuroblast and newborn neuron numbers but resulted in decreased newborn and proliferating NPCs. Inhibition of neurogenesis was observed after irradiation regardless of genotypes. In Cre-lox mice, there was further loss of newborn early NPCs and neuroblasts but not newborn neurons after irradiation compared with wild-type mice. These results are consistent with differential negative effect of AMPK on hippocampal neuronal development and its inhibition after irradiation.

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models

2021 ◽  
Vol 535 ◽  
pp. 87-92
Author(s):  
Ryohei Shimizu ◽  
Keiichi Ishihara ◽  
Eri Kawashita ◽  
Haruhiko Sago ◽  
Kazuhiro Yamakawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Mouse Models ◽  
Embryonic Brain ◽  
Adult Hippocampus

Nuclear Receptor NR5A2 Promotes Neuronal Identity in the Adult Hippocampus

2021 ◽  
Author(s):  
Matina Tsampoula ◽  
Isaak Tarampoulous ◽  
Ivi Antoniadou ◽  
Yassemi Koutmani ◽  
Dimitrios Gkikas ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Neuronal Identity ◽  
Adult Hippocampus

scholarly journals Brain erythropoietin fine-tunes a counterbalance between neurodifferentiation and microglia in the adult hippocampus

Cell Reports ◽  
2021 ◽  
Vol 36 (8) ◽  
pp. 109548
Author(s):  
Laura Fernandez Garcia-Agudo ◽  
Agnes A. Steixner-Kumar ◽  
Yasmina Curto ◽  
Nadine Barnkothe ◽  
Imam Hassouna ◽  
...  
Keyword(s):  
Adult Hippocampus

Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus

Nature ◽  
2004 ◽  
Vol 429 (6988) ◽  
pp. 184-187 ◽  
Author(s):  
Christoph Schmidt-Hieber ◽  
Peter Jonas ◽  
Josef Bischofberger
Keyword(s):  
Synaptic Plasticity ◽  
Granule Cells ◽  
Adult Hippocampus
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