scholarly journals Granule Cell Dispersion and Aberrant Neurogenesis in the Adult Hippocampus of an LIS1 Mutant Mouse

2006 ◽  
Vol 29 (1-2) ◽  
pp. 91-98 ◽  
Author(s):  
Yanling Wang ◽  
Scott C. Baraban
Keyword(s):  
Granule Cell ◽  
Mutant Mouse ◽  
Cell Dispersion ◽  
Adult Hippocampus

scholarly journals Increased Reelin Promoter Methylation Is Associated With Granule Cell Dispersion in Human Temporal Lobe Epilepsy

2009 ◽  
Vol 68 (4) ◽  
pp. 356-364 ◽  
Author(s):  
Katja Kobow ◽  
Ina Jeske ◽  
Michelle Hildebrandt ◽  
Jan Hauke ◽  
Eric Hahnen ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Promoter Methylation ◽  
Cell Dispersion ◽  
Human Temporal Lobe

scholarly journals Cell Proliferation and Granule Cell Dispersion in Human Hippocampal Sclerosis

2005 ◽  
Vol 64 (3) ◽  
pp. 194-201 ◽  
Author(s):  
Maria Thom ◽  
Lillian Martinian ◽  
Gareth Williams ◽  
Kai Stoeber ◽  
Sanjay M. Sisodiya
Keyword(s):  
Cell Proliferation ◽  
Granule Cell ◽  
Hippocampal Sclerosis ◽  
Cell Dispersion

scholarly journals Hippocampal morphometry in sudden and unexpected death in epilepsy

Neurology ◽  
2019 ◽  
Vol 93 (8) ◽  
pp. e804-e814 ◽  
Author(s):  
Alyma Somani ◽  
Anita-Beatrix Zborovschi ◽  
Yan Liu ◽  
Smriti Patodia ◽  
Zuzanna Michalak ◽  
...  
Keyword(s):  
Granule Cell ◽  
Hippocampal Sclerosis ◽  
Qualitative Evaluation ◽  
Granule Cell Layer ◽  
Parahippocampal Gyrus ◽  
Unexpected Death ◽  
Cell Dispersion ◽  
Autonomic Networks ◽  
Left And Right ◽  
The Right

ObjectiveTo determine hippocampal morphometric measures, including granule cell dispersion and features of malrotation, as potential biomarkers for sudden unexpected death in epilepsy (SUDEP) from an archival postmortem series.MethodsIn a retrospective study of 187 archival postmortems from 3 groups, SUDEP (68; 14 with hippocampal sclerosis [HS]), non-SUDEP epilepsy controls (EP-C = 66; 25 with HS), and nonepilepsy controls (NEC = 53), Nissl/hematoxylin & eosin–stained sections from left and right hippocampus from 5 coronal levels were digitized. Image analysis was carried out for granule cell layer (GCL) thickness and measurements of hippocampal dimensions (HD) for shape (width [HD1], height [HD2]) and medial hippocampal positioning in relation to the parahippocampal gyrus (PHG) length (HD3). A qualitative evaluation of hippocampal malrotational (HMAL) features, dentate gyrus invaginations (DGI), and subicular/CA1 folds (SCF) was also made.ResultsGCL thickness was increased in HS more than those without (p < 0.001). In non-HS cases, increased GCL thickness was noted in EP-C compared to NEC (p < 0.05) but not between SUDEP and NEC. There was no difference in the frequency of DGI, SCF, measurements of hippocampal shape (HD1, HD2, or ratio), or medial positioning among SUDEP, EP-C, and NEC groups, when factoring in HS, coronal level, and age at death. Comparison between left and right sides within cases showed greater PHG lengths (HD3) on the right side in the SUDEP group only (p = 0.018).ConclusionsNo hippocampal morphometric features were identified in support of either excessive granule cell dispersion or features of HMAL as definitive biomarkers for SUDEP. Asymmetries in PHG measurements in SUDEP warrant further investigation as they may indicate abnormal central autonomic networks.

scholarly journals Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics Investigation of Neurodevelopmental Migratory Pathways

2020 ◽  
Vol 14 ◽  
Author(s):  
Joan Y. W. Liu ◽  
Natasha Dzurova ◽  
Batoul Al-Kaaby ◽  
Kevin Mills ◽  
Sanjay M. Sisodiya ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Cell Dispersion ◽  
Human Temporal Lobe

Balloon cells associated with granule cell dispersion in the dentate gyrus in hippocampal sclerosis

2008 ◽  
Vol 115 (6) ◽  
pp. 697-700 ◽  
Author(s):  
M. Thom ◽  
L. Martinian ◽  
L. O. Caboclo ◽  
A. W. McEvoy ◽  
S. M. Sisodiya
Keyword(s):  
Dentate Gyrus ◽  
Granule Cell ◽  
Hippocampal Sclerosis ◽  
Balloon Cells ◽  
Cell Dispersion

scholarly journals Hippocampal morphometry in sudden and unexpected death in epilepsy (SUDEP)

2019 ◽  
Author(s):  
Alyma Somani ◽  
Anita-Beatrix Zborovschi ◽  
Yan Liu ◽  
Smriti Patodia ◽  
Zuzanna Michalak ◽  
...  
Keyword(s):  
Granule Cell ◽  
Hippocampal Sclerosis ◽  
Qualitative Evaluation ◽  
Granule Cell Layer ◽  
Parahippocampal Gyrus ◽  
Unexpected Death ◽  
Cell Dispersion ◽  
Significant Difference ◽  
Left And Right ◽  
The Right

ABSTRACTObjectiveTo determine hippocampal morphometric parameters, including granule cell dispersion and features of malrotation, as potential biomarkers for SUDEP from an archival post-mortem series.MethodsIn a retrospective study of 187 archival post-mortems from three groups, SUDEP (68; 14 with hippocampal sclerosis (HS)), non-SUDEP epilepsy controls (EP-C =66; 25 with HS) and non-epilepsy controls (NEC= 53), Nissl/H&E stained sections from left and right hippocampus from five coronal levels were digitised. Image analysis was carried out for granule cell layer (GCL) thickness and measurements of hippocampal dimensions (HD) for shape [width (HD1), height (HD2)] and medial hippocampal positioning in relation to the parahippocampal gyrus (PHG) length (HD3). A qualitative evaluation of hippocampal malrotational (HMAL) features, dentate gyrus invaginations (DGI) and subicular/CA1 folds (SCF) was also made.ResultsGCL thickness was increased in HS more than those without (p<0.001). In non-HS cases increased GCL thickness was noted in EP-C compared to NEC (p<0.05) but not between SUDEP and NEC. There was no significant difference in the frequency of DGI, SCF, measurements of hippocampal shape (HD1, HD2 or ratio) or medial positioning between SUDEP, EP-C and NEC groups, when factoring in HS, coronal level and age at death. Comparison between left and right sides within cases showed significantly greater PHG lengths (HD3) on the right side in the SUDEP group only (p=0.018)ConclusionsNo hippocampal morphometric features were identified in support of either excessive granule cell dispersion or features of HMAL as biomarkers for SUDEP. Asymmetries in PHG measurements in SUDEP warrant further investigation as they may indicate abnormal central autonomic networks.

scholarly journals Role for Reelin in the Development of Granule Cell Dispersion in Temporal Lobe Epilepsy

2002 ◽  
Vol 22 (14) ◽  
pp. 5797-5802 ◽  
Author(s):  
Carola A. Haas ◽  
Oliver Dudeck ◽  
Matthias Kirsch ◽  
Csaba Huszka ◽  
Gunda Kann ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Cell Dispersion
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