A single‐session behavioral protocol for successful event‐related potential recording in children with neurodevelopmental disorders

2021 ◽  
Vol 63 (7) ◽  
Author(s):  
Maggie W. Guy ◽  
Conner J. Black ◽  
Abigail L. Hogan ◽  
Ramsey E. Coyle ◽  
John E. Richards ◽  
...  
Keyword(s):  
Neurodevelopmental Disorders ◽  
Event Related Potential ◽  
Single Session ◽  
Potential Recording ◽  
Successful Event

scholarly journals Finding Suitable Clinical Endpoints for a Potential Treatment of a Rare Genetic Disease: the Case of ARID1B

2020 ◽  
Vol 17 (3) ◽  
pp. 1300-1310 ◽  
Author(s):  
Matthijs D. Kruizinga ◽  
Rob G.J.A. Zuiker ◽  
Elif Sali ◽  
Marieke L. de Kam ◽  
Robert J. Doll ◽  
...  
Keyword(s):  
Neurodevelopmental Disorders ◽  
Event Related Potential ◽  
Body Sway ◽  
Control Group ◽  
Clinical Endpoints ◽  
Non Invasive ◽  
Novel Approach ◽  
Sleep Parameters ◽  
Fit For Purpose ◽  
Potential Waveform

Abstract There is a lack of reliable, repeatable, and non-invasive clinical endpoints when investigating treatments for intellectual disability (ID). The aim of this study is to explore a novel approach towards developing new endpoints for neurodevelopmental disorders, in this case for ARID1B-related ID. In this study, twelve subjects with ARID1B-related ID and twelve age-matched controls were included in this observational case–control study. Subjects performed a battery of non-invasive neurobehavioral and neurophysiological assessments on two study days. Test domains included cognition, executive functioning, and eye tracking. Furthermore, several electrophysiological assessments were performed. Subjects wore a smartwatch (Withings® Steel HR) for 6 days. Tests were systematically assessed regarding tolerability, variability, repeatability, difference with control group, and correlation with traditional endpoints. Animal fluency, adaptive tracking, body sway, and smooth pursuit eye movements were assessed as fit-for-purpose regarding all criteria, while physical activity, heart rate, and sleep parameters show promise as well. The event-related potential waveform of the passive oddball and visual evoked potential tasks showed discriminatory ability, but EEG assessments were perceived as extremely burdensome. This approach successfully identified fit-for-purpose candidate endpoints for ARID1B-related ID and possibly for other neurodevelopmental disorders. Next, results could be replicated in different ID populations or the assessments could be included as exploratory endpoint in interventional trials in ARID1B-related ID.

scholarly journals Mapping Cortical Responses to Somatosensory Stimuli in Human Infants with Simultaneous Near-Infrared Spectroscopy and Event-Related Potential Recording

eNeuro ◽  
2016 ◽  
Vol 3 (2) ◽  
pp. ENEURO.0026-16.2016 ◽  
Author(s):  
Madeleine Verriotis ◽  
Lorenzo Fabrizi ◽  
Amy Lee ◽  
Robert J. Cooper ◽  
Maria Fitzgerald ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Event Related Potential ◽  
Human Infants ◽  
Cortical Responses ◽  
Potential Recording ◽  
Somatosensory Stimuli

Relation Between Event-Related Potential Latency and Saccade Latency in Overt Shifts of Attention

Perception ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 468-483 ◽  
Author(s):  
Louisa Kulke ◽  
Janette Atkinson ◽  
Oliver Braddick
Keyword(s):  
Time Course ◽  
Saccade Latency ◽  
Event Related Potential ◽  
Covert Attention ◽  
Neural Processing ◽  
Central Target ◽  
Single Target ◽  
Visual Behaviour ◽  
Potential Recording ◽  
A Current

Controlled shifts of attention between competing stimuli are crucial for effective everyday visual behaviour. While these typically involve overt shifts of fixation, many past studies used covert attention shifts in which fixation is unchanged, meaning that some response components may result from the inhibition of eye movements. In this study, the neural events in the human brain when making overt shifts of attention are studied through the combination of event-related potential recording with simultaneous eye tracking. Fixation shifts under competition (central target remains visible when a peripheral target appears) were compared with noncompetition (central target disappears). A longer latency for competition compared with noncompetition, which is found in the saccadic response, is already present in the early occipital positivity when a single target is presented for the fixation shift. These results indicate that the requirement to disengage from a current target affects the time course of neural processing at an early level. However, the relation is more complex when the participant is required to choose which of two targets to fixate.

Detection of simulated malingering using forced choice recognition enhanced with event-related potential recording

1996 ◽  
Vol 10 (2) ◽  
pp. 163-179 ◽  
Author(s):  
J. P. Rosenfeld ◽  
Jerry J. Sweet ◽  
James Chuang ◽  
Joel Ellwanger ◽  
Linda Song
Keyword(s):  
Forced Choice ◽  
Event Related Potential ◽  
Potential Recording

Effects of visual flickering stimuli for event-related potential recording

2016 ◽  
Author(s):  
Karunyapas Dangruan ◽  
Pongrawee Jatadhammakorn ◽  
Siwatch Luxsameepicheat ◽  
Montri Phothisonothai
Keyword(s):  
Event Related Potential ◽  
Potential Recording

Sensory and Cognitive Components of Auditory Processing in Individuals With Tinnitus

2019 ◽  
Vol 28 (4) ◽  
pp. 834-842
Author(s):  
Harini Vasudevan ◽  
Hari Prakash Palaniswamy ◽  
Ramaswamy Balakrishnan
Keyword(s):  
Selective Attention ◽  
Auditory Processing ◽  
Function Analysis ◽  
Event Related Potential ◽  
Oscillatory Activity ◽  
Default Mode ◽  
Auditory Selective Attention ◽  
Cognitive Components ◽  
Mode Function ◽  
Related Potentials

Purpose The main purpose of the study is to explore the auditory selective attention abilities (using event-related potentials) and the neuronal oscillatory activity in the default mode network sites (using electroencephalogram [EEG]) in individuals with tinnitus. Method Auditory selective attention was measured using P300, and the resting state EEG was assessed using the default mode function analysis. Ten individuals with continuous and bothersome tinnitus along with 10 age- and gender-matched control participants underwent event-related potential testing and 5 min of EEG recording (at wakeful rest). Results Individuals with tinnitus were observed to have larger N1 and P3 amplitudes along with prolonged P3 latency. The default mode function analysis revealed no significant oscillatory differences between the groups. Conclusion The current study shows changes in both the early sensory and late cognitive components of auditory processing. The change in the P3 component is suggestive of selective auditory attention deficit, and the sensory component (N1) suggests an altered bottom-up processing in individuals with tinnitus.

The Development of Swallowing Respiratory Coordination

2009 ◽  
Vol 18 (1) ◽  
pp. 19-24
Author(s):  
Maggie-Lee Huckabee
Keyword(s):  
Cortical Activation ◽  
First Year ◽  
Healthy Children ◽  
Nasal Airflow ◽  
Single Session ◽  
Primary Finding ◽  
Patterns Of Behavior ◽  
Cortical Modulation ◽  
First Year Of Life ◽  
Swallowing Apnea

Abstract Research exists that evaluates the mechanics of swallowing respiratory coordination in healthy children and adults as well and individuals with swallowing impairment. The research program summarized in this article represents a systematic examination of swallowing respiratory coordination across the lifespan as a means of behaviorally investigating mechanisms of cortical modulation. Using time-locked recordings of submental surface electromyography, nasal airflow, and thyroid acoustics, three conditions of swallowing were evaluated in 20 adults in a single session and 10 infants in 10 sessions across the first year of life. The three swallowing conditions were selected to represent a continuum of volitional through nonvolitional swallowing control on the basis of a decreasing level of cortical activation. Our primary finding is that, across the lifespan, brainstem control strongly dictates the duration of swallowing apnea and is heavily involved in organizing the integration of swallowing and respiration, even in very early infancy. However, there is evidence that cortical modulation increases across the first 12 months of life to approximate more adult-like patterns of behavior. This modulation influences primarily conditions of volitional swallowing; sleep and naïve swallows appear to not be easily adapted by cortical regulation. Thus, it is attention, not arousal that engages cortical mechanisms.

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