Gonadal steroid hormone secretion during the juvenile period depends on host-specific microbiota and contributes to the development of odor preference

2019 ◽  
Vol 61 (5) ◽  
pp. 670-678 ◽  
Author(s):  
Itsuka Kamimura ◽  
Akiyuki Watarai ◽  
Takuma Takamura ◽  
Atsushi Takeo ◽  
Kyoko Miura ◽  
...  
1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S21-S22 ◽  
Author(s):  
D. ENGELHARDT ◽  
H. SUTTMANN ◽  
K. JACOB ◽  
H.G. DÖRR

2020 ◽  
Vol 17 ◽  
pp. 100341 ◽  
Author(s):  
Habeeb Ashik Ahamed ◽  
Mohamed Jamal Mohamed ◽  
Kantha Deivi Arunachalam ◽  
G.I. Darul Raiyaan ◽  
Mohamed Saiyad Musthafa ◽  
...  

1981 ◽  
Vol 33 (5) ◽  
pp. 265-267 ◽  
Author(s):  
Charles B. Nemeroff ◽  
Coral A. Lamartiniere ◽  
George A. Mason ◽  
Robert E. Squibb ◽  
John S. Hong ◽  
...  

2009 ◽  
Vol 30 (3) ◽  
pp. 290-290
Author(s):  
Mabrouka Doghman ◽  
Julie Cazareth ◽  
Dominique Douguet ◽  
Franck Madoux ◽  
Peter Hodder ◽  
...  

ABSTRACT Context: Transcription factor steroidogenic factor-1 (SF-1) plays a pivotal role in the control of adrenocortical cell steroidogenesis and proliferation. SF-1 amplification and overexpression are found in most cases of childhood adrenocortical tumors (ACTs). Objective: Our objective was to investigate the effect of SF-1 inverse agonists of the alkyloxyphenol and isoquinolinone classes on the proliferation of human adrenocortical cell lines expressing SF-1 (H295R), in conditions of basal and increased SF-1 expression, or negative for SF-1 expression (SW-13). Main Outcome Measures: Proliferation assays, immunoblots, flow cytometric analyses, steroid hormone assays, and real-time quantitative PCR were used. Results: SF-1 inhibitors of the alkyloxyphenol class displayed a dose-dependent inhibitory effect on both SF-1-positive and -negative ACT cells, whereas SF-1 inverse agonists of the isoquinolinone class selectively inhibited cell proliferation elicited by SF-1 overexpression. These drugs also inhibited stimulated steroid hormone secretion and CYP21 and CYP17 mRNA expression. Conclusion: SF-1 inhibitors may represent a useful tool in the chemotherapy of ACTs.


2015 ◽  
Vol 232 (3) ◽  
pp. 573-579 ◽  
Author(s):  
Jing Wu ◽  
Di Tu ◽  
Li-Yun Yuan ◽  
Jin-e Yi ◽  
Yanan Tian

Sign in / Sign up

Export Citation Format

Share Document