The role of maternal stress during pregnancy, maternal discipline, and child COMT Val158Met genotype in the development of compliance

2012 ◽  
Vol 55 (5) ◽  
pp. 451-464 ◽  
Author(s):  
Rianne Kok ◽  
Marian J. Bakermans-Kranenburg ◽  
Marinus H. van IJzendoorn ◽  
Fleur P. Velders ◽  
Mariëlle Linting ◽  
...  
Keyword(s):  
Maternal Stress ◽  
Comt Val158met ◽  
Maternal Discipline

scholarly journals Maternal antioxidant treatment prevents behavioural and neural changes in offspring exposed to prenatal social stress

2019 ◽  
Author(s):  
H Scott ◽  
TJ Phillips ◽  
Y Sze ◽  
A Alfieri ◽  
MF Rogers ◽  
...  
Keyword(s):  
Conditioned Medium ◽  
Prenatal Stress ◽  
Social Stress ◽  
Maternal Stress ◽  
Later Life ◽  
Neuronal Cultures ◽  
Antioxidant Treatment ◽  
Foetal Brain ◽  
Increased Risk

AbstractMaternal exposure to social stress during pregnancy is associated with an increased risk of psychiatric disorders in the offspring in later life. However, the mechanism through which the effects of maternal stress are transmitted to the foetus is unclear. Using a rat model, we explored the mechanisms by which maternal social stress is conveyed to the foetus and the potential for targeted treatment to prevent disease in the offspring. Maternal stress increased circulating corticosterone in the mother, but not the foetuses. Maternal stress also induced oxidative stress in the placenta, but not in the foetal brain, and this was prevented by administration of a nanoparticle-bound antioxidant. Moreover, antioxidant treatment prevented prenatal stress-induced anxiety-like behaviour in the adult male offspring, along with several stress-induced neuroanatomical, neurochemical and gene expression changes in the offspring brain. Importantly, many of these neural effects were mimicked in neuronal cultures by application of placental-conditioned medium or foetal plasma from stressed pregnancies. Both placental-conditioned medium and foetal plasma contained differentially abundant extracellular microRNAs following prenatal stress. The present study highlights the crucial role of the placenta, and the molecules it secretes, in foetal brain development and provides evidence of the potential for treatment that can prevent maternal stress-induced foetal programming of neurological disease.

Examining The Link Between Harsh Parenting And Non-Suicidal Self-Injury In Adolescence: The Role of The COMT Val158Met Polymorphism And Depressive Symptoms

2021 ◽  
Author(s):  
Jinmeng Liu ◽  
Xia Liu ◽  
Hui Wang ◽  
Yemiao Gao
Keyword(s):  
High School Students ◽  
Depressive Symptoms ◽  
Junior High School ◽  
Longitudinal Design ◽  
Self Report ◽  
Harsh Parenting ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Self Injury

Abstract Background: Previous studies have suggested negative parenting environments, especially harsh parenting, is a specific risk factor for non-suicidal self-injury (NSSI). However, the potential mechanism between harsh parenting and NSSI has not been explored. Based on the experiential avoidance model and empirical researches, we aimed to examine if depressive symptoms are a mediator between harsh parenting and NSSI. Moreover, the catechol-O-methyltransferase (COMT) Val158Met polymorphism related to depressive symptoms may also exert a moderating effect on NSSI, thus, the interaction between harsh parenting and COMT were also considered in our study.Method：373 junior high school students were recruited for the study by using a longitudinal design. Adolescents answered self-report questionnaires and provided Saliva samples for DNA genotyping.Result：The results revealed that harsh parenting was positively associated with NSSI after 18 months, and this association was mediated by depressive symptoms. Moreover, the moderating role of COMT in the direct and indirect effect of harsh parenting on NSSI only among adolescents with two Val alleles. However, the relationship was not significant for Met carriers.Conclusion: Genetic variations of COMT Val158Met may be a critical candidate in understanding the development of depression and NSSI. We conclude that the Val homozygotes of the COMT Val158Met polymorphism play a susceptible role both in depressive symptoms and NSSI.

scholarly journals 25. Cortical Information Processing in Patients With Schizophrenia is Modulated by Tolcapone: Role of COMT val158met Genotype

2017 ◽  
Vol 43 (suppl_1) ◽  
pp. S17-S17
Author(s):  
Jose Apud ◽  
Yunxia Tong ◽  
Roberta Rasetti ◽  
Teresa Vargas ◽  
Joseph Callicott ◽  
...  
Keyword(s):  
Information Processing ◽  
Comt Val158met ◽  
Cortical Information Processing

scholarly journals The role of the COMT val158met polymorphism in mediating aversive learning in visual cortex

NeuroImage ◽  
2016 ◽  
Vol 125 ◽  
pp. 633-642 ◽  
Author(s):  
L. Forest Gruss ◽  
Taimour Langaee ◽  
Andreas Keil
Keyword(s):  
Visual Cortex ◽  
Aversive Learning ◽  
Comt Val158met ◽  
Val158met Polymorphism

scholarly journals Investigating the genetic basis of altruism: the role of the COMT Val158Met polymorphism

2010 ◽  
Vol 6 (5) ◽  
pp. 662-668 ◽  
Author(s):  
Martin Reuter ◽  
Clemens Frenzel ◽  
Nora T. Walter ◽  
Sebastian Markett ◽  
Christian Montag
Keyword(s):  
Genetic Basis ◽  
Comt Val158met ◽  
Val158met Polymorphism

scholarly journals Associations of Maternal-Infant Bonding with Maternal Mental Health, Infant’s Characteristics and Socio-Demographical Variables in the Early Postpartum Period: A Cross-Sectional Study

2021 ◽  
Vol 18 (16) ◽  
pp. 8517
Author(s):  
Łucja Bieleninik ◽  
Karolina Lutkiewicz ◽  
Mariusz Cieślak ◽  
Joanna Preis-Orlikowska ◽  
Mariola Bidzan
Keyword(s):  
Mental Health ◽  
Maternal Stress ◽  
Maternal Mental Health ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Significant Relationships ◽  
Early Postpartum ◽  
Postpartum Bonding ◽  
The Impact

(1) Background: There is a continuing discussion concerning the impact of preterm birth on Maternal-Infant bonding with inconsistent results. The large burden of preterm births calls for research to evaluate the impact of it on material psychological outcome in the early postpartum period. Thus, the aim of this study was to evaluate the relationship between maternal postpartum bonding with maternal mental health, socio-demographical factors, and child’s characteristics. (2) Methods: A cross-sectional study design was used. In total, 72 women (a mean age of 31.44 years old) of preterm infants (mean gestational age = 33.54; range 24–36) filled out socio-demographic questionnaires, Postpartum Bonding Questionnaire (PBQ), Edinburgh Postpartum Depression Scale (EPDS), Postpartum Depression Screening Scale (PDSS), Generalized Anxiety Disorder Assessment (GAD-7), and Parental Stress Scale (PSS) 1–3 days post-delivery; (3) Results: The results analyses have shown positive correlations between the overall result of maternal postpartum bonding with stress (p < 0.01), maternal educational level (p < 0.01), maternal age (p < 0.05) and the number of children (p < 0.01). However, there were no significant relationships between other investigated variables. The results of linear regression have revelated the important role of the overall scores in experience of stress among mothers (explaining 49% of the variability). The mediating role of maternal stress on maternal postpartum bonding was not found. That relationship of maternal postpartum bonding and maternal stress was not moderated through socio-demographic variables. (4) Conclusions: In this study mothers of prematurely born children had a good level of Maternal-Infant bonding. Maternal stress was found to be a predictor of maternal postpartum bonding among the tested variables. Surprisingly, the study results did not show significant relationships between maternal postpartum bonding and maternal mental health (depression and anxiety).

Mo2037 THE ROLE OF MATERNAL STRESS ON NEUROLOGICAL AND INTESTINAL DEVELOPMENT IN OFFSPRING

2020 ◽  
Vol 158 (6) ◽  
pp. S-1586
Author(s):  
Jessica A. Graham ◽  
Cristina A. Sanchez Rizek ◽  
Venkata Yeramilli ◽  
Chris Taylor ◽  
Sophie Chehade ◽  
...  
Keyword(s):  
Maternal Stress ◽  
Intestinal Development
Sign in / Sign up

Export Citation Format

Share Document