Adenosine A2a receptor expression in striatal neurons: Implications for basal ganglia pathophysiology

1993 ◽  
Vol 28 (3) ◽  
pp. 381-385 ◽  
Author(s):  
Serge N. Schiffmann ◽  
Pascale Halleux ◽  
Roberte Menu ◽  
Jean-Jacques Vanderhaeghen
Keyword(s):  
Basal Ganglia ◽  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
Striatal Neurons ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Correlation between low adenosine A2A receptor expression and hypercholesterolemia: A new component of the cardiovascular risk?

2021 ◽  
Vol 1866 (2) ◽  
pp. 158850
Author(s):  
Donato Vairo ◽  
Carola Giacobbe ◽  
Claire Guiol ◽  
Marie-Charlotte Chaptal ◽  
Maria Donata Di Taranto ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
A2a Receptor ◽  
Adenosine A2a

Lipopolysaccharide and TNF-α modify adenosine A2A receptor expression and function in equine monocytes

2010 ◽  
Vol 135 (3-4) ◽  
pp. 289-295 ◽  
Author(s):  
Wan-chun Sun ◽  
Londa J. Berghaus ◽  
James N. Moore ◽  
David J. Hurley ◽  
Michel L. Vandenplas ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
Tnf Α ◽  
A2a Receptor ◽  
And Function ◽  
Adenosine A2a

scholarly journals Different Adenosine A2A Receptor Expression in Peripheral Cells from Elderly Patients with Vascular Dementia and Alzheimer's Disease

2014 ◽  
Vol 40 (1) ◽  
pp. 45-49 ◽  
Author(s):  
Cristina Gussago ◽  
Beatrice Arosio ◽  
Martina Casati ◽  
Evelyn Ferri ◽  
Federica Gualandris ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Elderly Patients ◽  
Vascular Dementia ◽  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Peripheral Cells

Adenosine A2A receptor-induced inhibition of NMDA and GABAA receptor-mediated synaptic currents in a subpopulation of rat striatal neurons

2004 ◽  
Vol 46 (7) ◽  
pp. 994-1007 ◽  
Author(s):  
Kerstin Wirkner ◽  
Zoltan Gerevich ◽  
Thomas Krause ◽  
Albrecht Günther ◽  
Laszlo Köles ◽  
...  
Keyword(s):  
Gabaa Receptor ◽  
Adenosine A2a Receptor ◽  
Striatal Neurons ◽  
Synaptic Currents ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Striatal adenosine A2A receptor expression is controlled by S-adenosyl-L-methionine-mediated methylation

2014 ◽  
Vol 10 (3) ◽  
pp. 523-528 ◽  
Author(s):  
Izaskun Villar-Menéndez ◽  
Fabiana Nuñez ◽  
Sara Díaz-Sánchez ◽  
José Luis Albasanz ◽  
Jaume Taura ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Induction of murine adenosine A2A receptor expression by LPS: analysis of the 5′ upstream promoter

2013 ◽  
Vol 14 (3) ◽  
pp. 147-153 ◽  
Author(s):  
G Elson ◽  
M Eisenberg ◽  
C Garg ◽  
S Outram ◽  
C J Ferrante ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
Upstream Promoter ◽  
A2a Receptor ◽  
Adenosine A2a

Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression

2017 ◽  
Vol 55 (6) ◽  
pp. 4952-4958 ◽  
Author(s):  
Kristoffer Sahlholm ◽  
Maricel Gómez-Soler ◽  
Marta Valle-León ◽  
Marc López-Cano ◽  
Jaume J. Taura ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
Dopamine D2 ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Synthesis and Biological Evaluation of a Novel 18F-Labeled Radiotracer for PET Imaging of the Adenosine A2A Receptor

2021 ◽  
Vol 22 (3) ◽  
pp. 1182
Author(s):  
Thu Hang Lai ◽  
Magali Toussaint ◽  
Rodrigo Teodoro ◽  
Sladjana Dukić-Stefanović ◽  
Mathias Kranz ◽  
...  
Keyword(s):  
Total Activity ◽  
Biological Evaluation ◽  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
Positron Emission ◽  
A2a Receptor ◽  
Magnetic Resonance Imaging Mri ◽  
Adenosine A2a

The adenosine A2A receptor (A2AR) has emerged as a potential non-dopaminergic target for the treatment of Parkinson’s disease and, thus, the non-invasive imaging with positron emission tomography (PET) is of utmost importance to monitor the receptor expression and occupancy during an A2AR-tailored therapy. Aiming at the development of a PET radiotracer, we herein report the design of a series of novel fluorinated analogs (TOZ1-TOZ7) based on the structure of the A2AR antagonist tozadenant, and the preclinical evaluation of [18F]TOZ1. Autoradiography proved A2AR-specific in vitro binding of [18F]TOZ1 to striatum of mouse and pig brain. Investigations of the metabolic stability in mice revealed parent fractions of more than 76% and 92% of total activity in plasma and brain samples, respectively. Dynamic PET/magnetic resonance imaging (MRI) studies in mice revealed a brain uptake but no A2AR-specific in vivo binding.

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