scholarly journals Different Adenosine A2A Receptor Expression in Peripheral Cells from Elderly Patients with Vascular Dementia and Alzheimer's Disease

2014 ◽  
Vol 40 (1) ◽  
pp. 45-49 ◽  
Author(s):  
Cristina Gussago ◽  
Beatrice Arosio ◽  
Martina Casati ◽  
Evelyn Ferri ◽  
Federica Gualandris ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Elderly Patients ◽  
Vascular Dementia ◽  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Peripheral Cells

Association Analysis of Adenosine A2a Receptor 1976T>C Polymorphisms and Alzheimer’s Disease

2005 ◽  
Vol 53 (2) ◽  
pp. 99-100 ◽  
Author(s):  
Hsiu-Chih Liu ◽  
Chen-Jee Hong ◽  
Tsung-Yun Liu ◽  
Shih-Jen Tsai
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Analysis ◽  
Adenosine A2a Receptor ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1075 ◽  
Author(s):  
Rafael Franco ◽  
Rafael Rivas-Santisteban ◽  
Mireia Casanovas ◽  
Alejandro Lillo ◽  
Carlos A. Saura ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glutamate Receptor ◽  
Expression System ◽  
Primary Cultures ◽  
Adenosine A2a Receptor ◽  
A2a Receptors ◽  
Adenosine A2a Receptor Antagonists ◽  
A2a Receptor ◽  
Adenosine A2a

(1) Background. N-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR), which is one of the main targets to combat Alzheimer’s disease (AD), is expressed in both neurons and glial cells. The aim of this paper was to assess whether the adenosine A2A receptor (A2AR), which is a target in neurodegeneration, may affect NMDAR functionality. (2) Methods. Immuno-histo/cytochemical, biophysical, biochemical and signaling assays were performed in a heterologous cell expression system and in primary cultures of neurons and microglia (resting and activated) from control and the APPSw,Ind transgenic mice. (3) Results. On the one hand, NMDA and A2A receptors were able to physically interact forming complexes, mainly in microglia. Furthermore, the amount of complexes was markedly enhanced in activated microglia. On the other hand, the interaction resulted in a novel functional entity that displayed a cross-antagonism, that could be useful to prevent the exacerbation of NMDAR function by using A2AR antagonists. Interestingly, the amount of complexes was markedly higher in the hippocampal cells from the APPSw,Ind than from the control mice. In neurons, the number of complexes was lesser, probably due to NMDAR not interacting with the A2AR. However, the activation of the A2AR receptors resulted in higher NMDAR functionality in neurons, probably by indirect mechanisms. (4) Conclusions. A2AR antagonists such as istradefylline, which is already approved for Parkinson’s disease (Nouriast® in Japan and Nourianz® in the US), have potential to afford neuroprotection in AD in a synergistic-like fashion. i.e., via both neurons and microglia.

scholarly journals Correlation between low adenosine A2A receptor expression and hypercholesterolemia: A new component of the cardiovascular risk?

2021 ◽  
Vol 1866 (2) ◽  
pp. 158850
Author(s):  
Donato Vairo ◽  
Carola Giacobbe ◽  
Claire Guiol ◽  
Marie-Charlotte Chaptal ◽  
Maria Donata Di Taranto ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
A2a Receptor ◽  
Adenosine A2a

Lipopolysaccharide and TNF-α modify adenosine A2A receptor expression and function in equine monocytes

2010 ◽  
Vol 135 (3-4) ◽  
pp. 289-295 ◽  
Author(s):  
Wan-chun Sun ◽  
Londa J. Berghaus ◽  
James N. Moore ◽  
David J. Hurley ◽  
Michel L. Vandenplas ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
Tnf Α ◽  
A2a Receptor ◽  
And Function ◽  
Adenosine A2a

scholarly journals Striatal adenosine A2A receptor expression is controlled by S-adenosyl-L-methionine-mediated methylation

2014 ◽  
Vol 10 (3) ◽  
pp. 523-528 ◽  
Author(s):  
Izaskun Villar-Menéndez ◽  
Fabiana Nuñez ◽  
Sara Díaz-Sánchez ◽  
José Luis Albasanz ◽  
Jaume Taura ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Induction of murine adenosine A2A receptor expression by LPS: analysis of the 5′ upstream promoter

2013 ◽  
Vol 14 (3) ◽  
pp. 147-153 ◽  
Author(s):  
G Elson ◽  
M Eisenberg ◽  
C Garg ◽  
S Outram ◽  
C J Ferrante ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Receptor Expression ◽  
Upstream Promoter ◽  
A2a Receptor ◽  
Adenosine A2a
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