Hirudin prevents vascular endothelial cell apoptosis and permeability enhancement induced by the serum from rat with chronic renal failure through inhibiting RhoA / ROCK signaling pathway

2020 ◽  
Author(s):  
Jing Chen ◽  
Wenbin Shi ◽  
Yan Xu ◽  
Huaming Zhang ◽  
Bo Chen
Keyword(s):  
Renal Failure ◽  
Endothelial Cell ◽  
Chronic Renal Failure ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Vascular Endothelial ◽  
Endothelial Cell Apoptosis ◽  
Permeability Enhancement

scholarly journals Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion

2018 ◽  
Vol 38 (3) ◽  
Author(s):  
Chengfu Song ◽  
Xiangdong Zhao
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Artery Occlusion ◽  
Vascular Endothelial ◽  
Endothelial Cell Apoptosis ◽  
Related Factors ◽  
Cerebral Artery Occlusion

In patients with cerebral infarction (CI), elevated serum uric acid (UA) level may exacerbate the occurrence and development of carotid atherosclerosis (AS). Our study intended to explore the underlying mechanism. We enrolled 86 patients with CI, and divided them into four groups: Non-AS, AS-mild, AS-moderate, and AS-severe groups; the levels of UA and oxidative stress-related factors in serum were detected. The middle cerebral artery occlusion (MCAO) model was used to stimulate CI in rats, and different doses of UA were administrated. The levels of oxidative stress-related factors in serum were detected. Hematoxylin & eosin (H&E) staining was used to observe the morphological alterations, and the apoptotic cell death detection kit was used to detect apoptotic cells. Increased UA concentration and enhanced oxidative stress were found in AS patients. H&E staining results showed that UA treatment exacerbated morphological damage in rats with MCAO, promoted oxidative stress, and enhanced vascular endothelial cell apoptosis in rats with MCAO.

Crocetin prevents AGEs-induced vascular endothelial cell apoptosis

2006 ◽  
Vol 54 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Min Xiang ◽  
Min Yang ◽  
Chenghua Zhou ◽  
Juan Liu ◽  
Wenna Li ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Vascular Endothelial ◽  
Endothelial Cell Apoptosis

scholarly journals Pericardial fluid from patients with unstable angina induces vascular endothelial cell apoptosis

2000 ◽  
Vol 35 (7) ◽  
pp. 1785-1790 ◽  
Author(s):  
Atsushi Iwakura ◽  
Masatoshi Fujita ◽  
Koji Hasegawa ◽  
Tatsuya Sawamura ◽  
Ryuji Nohara ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Unstable Angina ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Pericardial Fluid ◽  
Vascular Endothelial ◽  
Endothelial Cell Apoptosis

MiR-126 inhibits vascular endothelial cell apoptosis through targeting PI3K/Akt signaling

2015 ◽  
Vol 95 (3) ◽  
pp. 365-374 ◽  
Author(s):  
Lingqiang Chen ◽  
Jing Wang ◽  
Bing Wang ◽  
Jin Yang ◽  
Zhiqiang Gong ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Apoptosis ◽  
Vascular Endothelial Cell ◽  
Akt Signaling ◽  
Vascular Endothelial ◽  
Endothelial Cell Apoptosis
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