Marine bacteria and fungi as promising source for new antibiotics

2018 ◽  
Vol 80 (1) ◽  
pp. 24-27 ◽  
Author(s):  
Jutta Wiese ◽  
Johannes F. Imhoff
Keyword(s):  
Marine Bacteria ◽  
New Antibiotics ◽  
Bacteria And Fungi ◽  
Promising Source

Colombian frogs: promising source of new antibiotics

2020 ◽  
Author(s):  
Esteban Alzate ◽  
Laura Mejía ◽  
Maria Clara Nuñez ◽  
Julie Benavides ◽  
David Galvis-Pareja ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
E Coli ◽  
Microdilution Method ◽  
Comparable Effect ◽  
Frog Species ◽  
New Antibiotics ◽  
Inhibition Zones ◽  
Human Use ◽  
Promising Source ◽  
Positive Controls

Abstract Background: In middle Magdalena of the Antioquia region, Colombia frog secretions have been used as antibacterial agents, the purpose of this study is to assess the antibacterial activity of six frog species secretions. Methods: the Kirby-Bauer and the microdilution methods were used to evaluate antibacterial activity of the frogs secretions against S. aureus and E. coli, using two positive controls, ampicillin and ciprofloxacin. Results: secretions of all six families showed inhibition zones, the concentration at which this zone was bigger was assayed later by the microdilution method and compared to ampicillin and ciprofloxacin. Only the secretion from the Phyllomedusidae exhibited a comparable effect to that one of control antibiotics. Conclusions: in here we provide evidence that secretions from local frogs have an antibacterial effect against two strains of bacteria, further studies are needed to identify the peptides in the secretions and a wider range of safe concentrations for human use.

scholarly journals Metal complexes as a promising source for new antibiotics

2020 ◽  
Vol 11 (10) ◽  
pp. 2627-2639 ◽  
Author(s):  
Angelo Frei ◽  
Johannes Zuegg ◽  
Alysha G. Elliott ◽  
Murray Baker ◽  
Stefan Braese ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Metal Complexes ◽  
Organic Molecules ◽  
Hit Rate ◽  
New Antibiotics ◽  
New Compounds ◽  
Eskape Pathogens ◽  
Promising Source

There is a dire need for new compounds to combat antibiotic resistance: metal complexes might provide the solution. 906 metal complexes were evaluated against dangerous ESKAPE pathogens and found to have a higher hit-rate than organic molecules.

scholarly journals Correction: Metal complexes as a promising source for new antibiotics

2020 ◽  
Vol 11 (17) ◽  
pp. 4531-4531 ◽  
Author(s):  
Angelo Frei ◽  
Johannes Zuegg ◽  
Alysha G. Elliott ◽  
Murray Baker ◽  
Stefan Braese ◽  
...  
Keyword(s):  
Metal Complexes ◽  
New Antibiotics ◽  
Promising Source

Correction for ‘Metal complexes as a promising source for new antibiotics’ by Angelo Frei et al., Chem. Sci., 2020, 11, 2627–2639.

The Himanimides, New Bioactive Compounds From Serpula Himantoides (Fr.)Karst.

2002 ◽  
Vol 57 (3-4) ◽  
pp. 257-262 ◽  
Author(s):  
Pedro Aqueveque ◽  
Timm Anke ◽  
Olov Sterner
Keyword(s):  
Bioactive Compounds ◽  
Spectroscopic Methods ◽  
New Antibiotics ◽  
Bacteria And Fungi ◽  
Derivatives Of ◽  
Growth Of Bacteria

In a screening of basidiomycete cultures from Chile for the production of antibiotics we identified a Serpula himantoides strain as a producer of metabolites inhibiting the growth of bacteria and fungi. Bioactivity guided purification resulted in the isolation of four new antibiotics. Their structures were elucidated by spectroscopic methods. All four compounds are succinimide and maleimide derivatives, of which two are N-hydroxylated

Something old, something new: revisiting natural products in antibiotic drug discovery

2014 ◽  
Vol 60 (3) ◽  
pp. 147-154 ◽  
Author(s):  
Gerard D. Wright
Keyword(s):  
Natural Products ◽  
New Drugs ◽  
Clinical Use ◽  
Antibiotic Resistant ◽  
Antibiotic Drug ◽  
New Antibiotics ◽  
Bacteria And Fungi ◽  
Antibiotic Discovery ◽  
Novel Drug ◽  
New Strategies

Antibiotic discovery is in crisis. Despite a growing need for new drugs resulting from the increasing number of multi-antibiotic-resistant pathogens, there have been only a handful of new antibiotics approved for clinical use in the past 2 decades. Faced with scientific, economic, and regulatory challenges, the pharmaceutical sector seems unable to respond to what has been called an “apocalyptic” threat. Natural products produced by bacteria and fungi are genetically encoded products of natural selection that have been the mainstay sources of the antibiotics in current clinical use. The pharmaceutical industry has largely abandoned these compounds in favor of large libraries of synthetic molecules because of difficulties in identifying new natural product antibiotics scaffolds. Advances in next-generation genome sequencing, bioinformatics, and analytical chemistry are combining to overcome barriers to natural products. Coupled with new strategies in antibiotic discovery, including inhibition of resistance, novel drug combinations, and new targets, natural products are poised for a renaissance to address what is a pressing health care crisis.

scholarly journals Co-culture of soil biofilm isolates enables the discovery of novel antibiotics

2018 ◽  
Author(s):  
Chun-Hui Gao ◽  
Peng Cai ◽  
Zhunjie Li ◽  
Yichao Wu ◽  
Qiaoyun Huang
Keyword(s):  
Bacterial Species ◽  
Gene Clusters ◽  
The Social ◽  
New Antibiotics ◽  
Interaction Strategy ◽  
Transcriptomic Changes ◽  
Antibiotic Discovery ◽  
Promising Source ◽  
Novel Antibiotics ◽  
Biofilm Community

AbstractBacterial natural products (NPs) are considered to be a promising source of drug discovery. However, the biosynthesis gene clusters (BGCs) of NP are not often expressed, making it difficult to identify them. Recently, the study of biofilm community showed bacteria may gain competitive advantages by the secretion of antibiotics, implying a possible way to screen antibiotic by evaluating the social behavior of bacteria. In this study, we have described an efficient workflow for novel antibiotic discovery by employing the bacterial social interaction strategy with biofilm cultivation, co-culture, transcriptomic and genomic methods. We showed that a biofilm dominant species, i.e. Pseudomonas sp. G7, which was isolated from cultivated soil biofilm community, was highly competitive in four-species biofilm communities, as the synergistic combinations preferred to exclude this strain while the antagonistic combinations did not. Through the analysis of transcriptomic changes in four-species co-culture and the complete genome of Pseudomonas sp. G7, we finally discovered two novel non-ribosomal polypeptide synthetic (NRPS) BGCs, whose products were predicted to have seven and six amino acid components, respectively. Furthermore, we provide evidence showing that only when Pseudomonas sp. G7 was co-cultivated with at least two or three other bacterial species can these BGC genes be induced, suggesting that the co-culture of the soil biofilm isolates is critical to the discovery of novel antibiotics. As a conclusion, we set a model of applying microbial interaction to the discovery of new antibiotics.

scholarly journals Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals

Marine Drugs ◽  
2021 ◽  
Vol 19 (10) ◽  
pp. 572
Author(s):  
Chao-Qun Li ◽  
Qin-Yuan Ma ◽  
Xiu-Zhen Gao ◽  
Xuan Wang ◽  
Bei-Li Zhang
Keyword(s):  
Marine Bacteria ◽  
Marine Organism ◽  
Research Progress ◽  
Defense Reaction ◽  
Marine Microorganisms ◽  
Bioactive Substances ◽  
Evaluation Models ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Bacteria And Fungi

Inflammation is the body’s defense reaction in response to stimulations and is the basis of various physiological and pathological processes. However, chronic inflammation is undesirable and closely related to the occurrence and development of diseases. The ocean gives birth to unique and diverse bioactive substances, which have gained special attention and been a focus for anti-inflammatory drug development. So far, numerous promising bioactive substances have been obtained from various marine organisms such as marine bacteria and fungi, sponges, algae, and coral. This review covers 71 bioactive substances described during 2015–2020, including the structures (65 of which), species sources, evaluation models and anti-inflammatory activities of these substances. This review aims to provide some reference for the research progress of marine-organism-derived anti-inflammatory metabolites and give more research impetus for their conversion to novel anti-inflammatory drugs.

scholarly journals Screening Fungal Endophytes Derived from Under-Explored Egyptian Marine Habitats for Antimicrobial and Antioxidant Properties in Factionalised Textiles

2020 ◽  
Vol 8 (10) ◽  
pp. 1617
Author(s):  
Ahmed A. Hamed ◽  
Sylvia Soldatou ◽  
M. Mallique Qader ◽  
Subha Arjunan ◽  
Kevin Jace Miranda ◽  
...  
Keyword(s):  
Endophytic Fungi ◽  
Pathogenic Bacteria ◽  
Antioxidant Activities ◽  
Human Fibroblasts ◽  
Fungal Endophytes ◽  
Antioxidant Properties ◽  
Chemical Screening ◽  
Marine Habitats ◽  
Bacteria And Fungi ◽  
Promising Source

Marine endophytic fungi from under-explored locations are a promising source for the discovery of new bioactivities. Different endophytic fungi were isolated from plants and marine organisms collected from Wadi El-Natrun saline lakes and the Red Sea near Hurghada, Egypt. The isolated strains were grown on three different media, and their ethyl acetate crude extracts were evaluated for their antimicrobial activity against a panel of pathogenic bacteria and fungi as well as their antioxidant properties. Results showed that most of the 32 fungal isolates initially obtained possessed antimicrobial and antioxidant activities. The most potent antimicrobial extracts were applied to three different cellulose containing fabrics to add new multifunctional properties such as ultraviolet protection and antimicrobial functionality. For textile safety, the toxicity profile of the selected fungal extract was evaluated on human fibroblasts. The 21 strains displaying bioactivity were identified on molecular basis and selected for chemical screening and dereplication, which was carried out by analysis of the MS/MS data using the Global Natural Products Social Molecular Networking (GNPS) platform. The obtained molecular network revealed molecular families of compounds commonly produced by fungal strains, and in combination with manual dereplication, further previously reported metabolites were identified as well as potentially new derivatives.

scholarly journals Litsea glutinosa (Lauraceae): Evaluation of its Foliar Phytochemical Constituents for Antimicrobial Activity

2018 ◽  
Vol 10 (1) ◽  
pp. 21-25
Author(s):  
Mutyala Naidu LAGUDU ◽  
Aniel Kumar OWK
Keyword(s):  
Antimicrobial Activity ◽  
Bacterial Strains ◽  
Gram Positive Bacteria ◽  
Inhibition Concentration ◽  
Phytochemical Investigation ◽  
New Antibiotics ◽  
Phytochemical Constituents ◽  
Litsea Glutinosa ◽  
Bacteria And Fungi ◽  
Dose Dependent

The phytochemical investigation of the leaves of Litsea glutinosa revealed the presence of secondary metabolites like alkaloids, anthraquinones, cardiac glycosides, flavonoids, glycosides, phenols, saponins, steroids, tannins, terpenoids, volatile compounds, amino acids and carbohiydrates. The antimicrobial activity and minimum inhibition concentration values were determined for these phytochemical constituents as crude extracts using the agar well diffusion and two-fold serial dilution methods. The results indicated that Bacillus subtilis was the most susceptible bacterium with high inhibition zones for the methanol and chloroform extracts of 31 mm and 26 mm, respectively. The MIC values indicated that extracts possess good antimicrobial activity with significant MIC value against Enterococcus faecalis, Pseudomonas aeruginosa and Staphylococcus pneumoniae at 31.2 µg/ml concentrations. The extracts showed marked antimicrobial activity against both bacteria and fungi. Among the bacterial strains, gram-positive bacteria were more susceptible than the gram-negative. All the 13 microorganisms tested showed dose dependent susceptibility towards the phytochemicals present in the foliar extracts. The study suggests that Litsea glutinosa leaves possess potent antimicrobial activity and can be a good source for the development of new antibiotics.

Marine Bacteria. Part 29. 1-Hydroxy-1-norresistomycin and Resistoflavin Methyl Ether: New Antibiotics from Marine-Derived Streptomycetes.

ChemInform ◽  
2006 ◽  
Vol 37 (3) ◽  
Author(s):  
Ines Kock ◽  
Rajendra P. Maskey ◽  
M. A. Farooq Biabani ◽  
Elisabeth Helmke ◽  
Hartmut Laatsch
Keyword(s):  
Methyl Ether ◽  
Marine Bacteria ◽  
New Antibiotics
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