Detection of Treponema pallidum by immunocytochemistry of cervical smear: A case report

2021 ◽  
Author(s):  
Hiroshi Noguchi ◽  
Takako Tokumitsu ◽  
Eiteru Kuroki ◽  
Eiko Minematsu ◽  
Yujiro Asada ◽  
...  
Keyword(s):  
Case Report ◽  
Treponema Pallidum ◽  
Cervical Smear

Cytopathologic Manifestation of Uterine Leiomyosarcoma. Case Report

1978 ◽  
Vol 64 (2) ◽  
pp. 205-210
Author(s):  
Silvana Pilotti ◽  
Loredana Alasio
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Tumor Cells ◽  
Vaginal Bleeding ◽  
Pulmonary Metastases ◽  
Malignant Neoplasms ◽  
Uterine Leiomyosarcoma ◽  
Cervical Smear ◽  
Isolated Cells ◽  
Cytologic Diagnosis

The presence of malignant tumor cells in a vaginal and cervical smear of a 53-year-old female with vaginal bleeding and with subsequent negative histology of the scraping material could be later correlated with a leiomyosarcoma of the myometrium that produced deep local invasion and pulmonary metastases. The findings that favor the cytologic diagnosis of this neoplasm are the presence of isolated cells or the side-by-side arrangement of the tumor cells, the elongated shape of the cytoplasm, and the ovoidal cigar-shaped nuclei with sparse, coarse chromocenters. Cytologic differential diagnosis of other malignant neoplasms capable of cellular exfoliation into the vagina is discussed.

Primary relapse of acute lymphoblastic leukemia in a cervical smear: A case report

2006 ◽  
Vol 34 (7) ◽  
pp. 499-502 ◽  
Author(s):  
Akiko Ikuta ◽  
Junko Saito ◽  
Tomomi Mizokami ◽  
Masami Asano ◽  
Tsuyoshi Nakamoto ◽  
...  
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Cervical Smear

Syphilitic chorioretinitis presenting as a choroidal granuloma

2020 ◽  
Vol 13 (4) ◽  
pp. e234022
Author(s):  
Avantika Dogra ◽  
Mudit Tyagi ◽  
Hrishikesh Kaza ◽  
Avinash Pathengay
Keyword(s):  
Case Report ◽  
Complete Resolution ◽  
Research Laboratory ◽  
Rare Case ◽  
Venereal Disease ◽  
Treponema Pallidum ◽  
Venereal Disease Research Laboratory ◽  
Hemagglutination Assay ◽  
Disease Research ◽  
Choroidal Granuloma

A rare case of syphilitic uveitis presenting as a choroidal granuloma is described in this case report. The clinical picture resembled that of a tubercular choroidal granuloma. However, the patient was positive for treponemal (treponema pallidum hemagglutination assay) as well as non-treponemal tests (venereal disease research laboratory test) for syphilis. Therefore, the patient was treated for ocular syphilis and responded to antisyphilitic therapy. There was a complete resolution of the lesion at the end of 14 days of treatment.

scholarly journals Significance of the combined tests application in serum and liquor of patients with suspected neurosyphilis

2007 ◽  
Vol 64 (4) ◽  
pp. 271-274
Author(s):  
Mihailo Mirkovic ◽  
Vilma Jovicic ◽  
Ivana Basta ◽  
Ivan Marjanovic ◽  
Dragana Lavrnic
Keyword(s):  
Case Report ◽  
Treponema Pallidum ◽  
Developed Countries ◽  
Differential Diagnostics ◽  
Psychotic Symptoms ◽  
Clinical Image ◽  
Western Blot Method ◽  
Normal Number ◽  
Tabes Dorsalis ◽  
The Developed Countries

Background. Tertiary syphilis develops in 8-40% of untreated patients. It is most commonly manifested in the form of neurosyphilis, which can be asymptomatic taking the form of tabes dorsalis or progressive paralyze. Nowadays, in the developed countries, progressive paralyze is a rather rare disease, although the incidence of this disease has been rising within the last decades. Case report. We reported a 74-year-old male with the clinical image of dementia showing psychotic symptoms. On cytobiochemical examination of cerebrospinal liquor, hyperproteinorhacmia of 0.70 g/l with the normal number of cells was revealed. Computed tomography of the brain showed the marked cortical cerebral and cerebellar reduction changes with multiple ischemic lesions. Within a routine examination of patients with demention, we performed serologic reactions to syphilis out of which the Veneral Disease Researc Laboratory (VDRL) test in serum and liquor was unreactive, while the Treponema pallidum hemagglutination (TPNA) test in serum and liquor was positive. Positivity in serum and liquor was additionally confirmed by the Western blot method and fluoroscent treponema antibody (FTA) test. The treatment with benzathine fenylpenicilline 2.4 g once weekly resulted in significant improving the psychotic symptoms of the disease even after two weeks. Conclusion. This case report showed that within the differential diagnostics in patients with demention or psychotic disorder it is obligatory to consider syphilis of the nervous system, as well as to apply a combination of various tests which, besides the typical liquor findings, significantly improve the accuracy of diagnosis. Such approach is especially important regarding the fact that neurosyphilis can remain clinically quite asymptomatic for a long period, which could lead to late therapy, while, on the contrary, an adequate and timely treatment can contribute to a significant recovery of any patients.

scholarly journals Neurosyphilis Manifesting With Bilateral Adie’s Pupil: A Case Report

2019 ◽  
Author(s):  
Ya-ping Zhou ◽  
Ji-Wei Jiang ◽  
Mei-qing Lin ◽  
Mei-Xin Li ◽  
Xiu-Li Shang
Keyword(s):  
Cerebrospinal Fluid ◽  
Case Report ◽  
Treponema Pallidum ◽  
Final Diagnosis ◽  
Case Presentation ◽  
Elevated Protein ◽  
Syphilis Treatment ◽  
Syphilis Screening ◽  
Particle Agglutination ◽  
Csf Examination

Abstract Background Pupillary abnormalities play an important role in identification of neurosyphilis. Among them, Argyll Roberston pupil is most typical and has been mentioned in many reports and studies. However, papers about Adie’s pupil associated with neurosyphilis are extremely rare. In the present study, we report a case of patient with bilateral Adie’s pupils as isolated manifestation of neurosyphilis. Case presentation we describe a 58-year-old retired Chinese woman with bilateral Adie’s pupils. Further evaluation revealed serologically positive for Treponema pallidum particle agglutination (TPPA), chemiluminescence immunoassays (CLIA) and rapid plasma regain (RPR) test (1:16). The Cerebrospinal fluid (CSF) examination revealed pleocytosis, elevated protein, and positive RPR (1:2), TPPA and CLIA. Final diagnosis of Adie’s pupils associated with neurosyphilis was made and other possible causes were excluded. Cephalosporin was used for treatment due to penicillin allergy. Despite effective anti-syphilis treatment, her pupils remained unchanged. Conclusions Adie’s pupil can be caused by neurosyphilis and is one of the most important pupillary changes in early neurosyphilis. Our study further underscore the necessity of syphilis screening in patients with Adie’s pupil due to further treatment consideration.

scholarly journals Serous adenocarcinoma detected in the cervical smear: A case report

2020 ◽  
Vol 73 (9-10) ◽  
pp. 321-325
Author(s):  
Ljiljana Tadic-Latinovic ◽  
Ilija Baros ◽  
Danijela Batinic-Skipina ◽  
Slavica Maric
Keyword(s):  
Case Report ◽  
Precancerous Lesions ◽  
Transvaginal Ultrasound ◽  
Abdominal Cavity ◽  
Diagnostic Methods ◽  
Cervical Canal ◽  
High Grade ◽  
Cervical Smear ◽  
Serous Adenocarcinoma ◽  
Cervical Biopsy

Introduction. Cytological smear tests of the cervix are routine diagnostic methods used for detection of precancerous lesions and tumors of the cervix; they are highly sensitive and specific in the detection of precancerous squamous intraepithelial lesions. Glandular lesions are much less frequently found in the cervical smear. The most common glandular lesions detected in the cervical smear are endocervical and endometrial adenocarcinomas. Cervical metastases are rare, although there are case reports in the literature. Case Report. In this case report, we present a 64-year-old woman with an abnormal cervical smear and postmenopausal metrorrhagia. Numerous accumulations, as well as individual atypical epithelial cells, were detected in the cervical smear and a cytological diagnosis of a highgrade squamous intraepithelial lesion was made based on cytomorphological features suspicious for invasion (Bethesda Classification, 2014) so a cervical biopsy and curettage of the endocervical canal were performed. A high-grade serous adenocarcinoma was diagnosed by histopathological examination of cervical biopsy and cervical canal curettage specimens, after which a transvaginal ultrasound examination was performed, which showed tumors on both ovaries and free fluid in the abdominal cavity. The patient underwent abdominal hysterectomy with bilateral salpingo-oophorectomy. Histological examination confirmed high-grade ovarian papillary serous adenocarcinoma with psammoma bodies. Conclusion. The cytological diagnostic features and criteria for serous adenocarcinoma in Papanicolaou smears are still vague and insufficiently defined in the literature, which is the reason for very common errors in the interpretation, so further research on the pathogenesis, diagnosis and therapy of this tumor is of great importance.

scholarly journals Myelopathy secondary to human T-lymphotropic virus and Treponema pallidum infection: case report

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Pilar Enríquez-Ruano ◽  
Cristian Eduardo Navarro ◽  
Michael Ariza-Varón ◽  
Andrea del Pilar Calderón-Castro
Keyword(s):  
Case Report ◽  
Treponema Pallidum ◽  
T Lymphotropic Virus

scholarly journals Congenital Syphilis: A Case Report

2020 ◽  
Vol 18 (1) ◽  
pp. 73-75
Author(s):  
Saujan Subedi ◽  
Jayanti Jwarchan ◽  
Shashwata Raj Pandit ◽  
Saraswoti Neupane
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Congenital Syphilis ◽  
Treponema Pallidum ◽  
In Utero ◽  
Male Child

Congenital syphilis is a chronic infectious disease caused by Treponema pallidum, a spirochete acquired in-utero by the fetus. Syphilis continues to affect pregnant population, in spite of various measures to control. Here we report a case of congenital syphilis in a two-year-old male child.

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