scholarly journals Serous adenocarcinoma detected in the cervical smear: A case report

2020 ◽  
Vol 73 (9-10) ◽  
pp. 321-325
Author(s):  
Ljiljana Tadic-Latinovic ◽  
Ilija Baros ◽  
Danijela Batinic-Skipina ◽  
Slavica Maric

Introduction. Cytological smear tests of the cervix are routine diagnostic methods used for detection of precancerous lesions and tumors of the cervix; they are highly sensitive and specific in the detection of precancerous squamous intraepithelial lesions. Glandular lesions are much less frequently found in the cervical smear. The most common glandular lesions detected in the cervical smear are endocervical and endometrial adenocarcinomas. Cervical metastases are rare, although there are case reports in the literature. Case Report. In this case report, we present a 64-year-old woman with an abnormal cervical smear and postmenopausal metrorrhagia. Numerous accumulations, as well as individual atypical epithelial cells, were detected in the cervical smear and a cytological diagnosis of a highgrade squamous intraepithelial lesion was made based on cytomorphological features suspicious for invasion (Bethesda Classification, 2014) so a cervical biopsy and curettage of the endocervical canal were performed. A high-grade serous adenocarcinoma was diagnosed by histopathological examination of cervical biopsy and cervical canal curettage specimens, after which a transvaginal ultrasound examination was performed, which showed tumors on both ovaries and free fluid in the abdominal cavity. The patient underwent abdominal hysterectomy with bilateral salpingo-oophorectomy. Histological examination confirmed high-grade ovarian papillary serous adenocarcinoma with psammoma bodies. Conclusion. The cytological diagnostic features and criteria for serous adenocarcinoma in Papanicolaou smears are still vague and insufficiently defined in the literature, which is the reason for very common errors in the interpretation, so further research on the pathogenesis, diagnosis and therapy of this tumor is of great importance.

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mohammed Nagdi Zaki ◽  
Aafia Mohammed Farooq Gheewale ◽  
Nada Ibrahim ◽  
Ibrahim Abd Elrahman

Abstract Background An adenomyoma is a well circumscribed form of adenomyosis and can be located within the myometrium, in the endometrium as a polyp, or extrauterine with the last being the rarest presentation amongst the three. With the ongoing advancement in gynecological surgery, the use of electromechanical morcellators have made the removal of large and dense specimens possible with minimally invasive techniques. However, it has also caused an increase in complications which were previously rare. Whilst the tissue is being grinded within the abdominal cavity, residual tissue can spread and remain inside, allowing for implantation to occur and thereby giving rise to recurrence of uterine tissue as a new late postoperative complication. Case presentation A 45-year-old woman presented with worsening constipation and right iliac fossa pain. Her past surgical history consists of laparoscopic supra-cervical hysterectomy that was indicated due to uterine fibroids. Computerized tomography and magnetic resonance imaging were done, which showed an irregular lobulated heterogeneous mass seen in the presacral space to the right, located on the right lateral aspect of the recto-sigmoid, measuring 4.5 × 4.3 × 4.3 cm in size. A transvaginal ultrasound revealed a cyst in the left ovary. The patient had a treatment course over several months that included Dienogest (progestin) and Goserelin (GnRH analogue) with add-back therapy. In line with the declining response to medications, the patient was advised for a laparoscopic ovarian cystectomy. During the surgery, an additional lesion was found as a suspected fibroid and the left ovarian cyst was identified as pockets of peritoneal fluid which was sent for cytology. The surgical pathology report confirmed adenomyosis in both specimens, namely the right mass and the initially suspected fibroid. Conclusion In this case report, we showcase a rare occurrence of an extrauterine adenomyoma presenting two years post laparoscopic morcellation at hysterectomy. This poses questions regarding the benefits versus risks of power morcellation in laparoscopic hysterectomy.


2020 ◽  
pp. 1-3
Author(s):  
Sonia Soto-Schutte ◽  
Sonia Soto-Schutte ◽  
Fernado Mendoza-Moreno ◽  
Javier Mínguez-García ◽  
Enrique Ovejero-Merino ◽  
...  

Parasitic myomas are an infrequent type of myomas that appear in abdominal cavity. The incidence of this pathology has increased over the past years. There has been many hypothesis about the pathogenesis. One of the most recent ones is in relation to the start of laparoscopic morcellation at myomectomy or hysterectomy to treat uterine myomas due to the small fragments that can be detached during the procedure and that implant themselves in the abdominal cavity. Parasitic myomas, in most cases, are asymptomatic, but it can cause an unspecific abdominal pain, menstrual disturbances, dyspareunia and other gynecological symptoms. Physical exploration in patients is often also normal. The correct identification of parasitic myoma by image tests, such as transvaginal ultrasound, CT or MRI, is still complicated because it is difficult to diagnose due to the unspecific radiological characteristics that show up. CT and MRI give information about the location that could be useful during the surgery. Usually the diagnosis is an accidental finding during an abdominal surgery done for another reason and the histology of the piece is what gives the definitive diagnosis. We present a case of a 32-year-old woman, asymptomatic, after a transvaginal ultrasound is diagnosed a retroperitoneal tumor. The tumor was removed by laparoscopic surgery and the patient had a favourable recovery. The histopathology of the tumor was a parasitic myoma.


GYNECOLOGY ◽  
2020 ◽  
Vol 21 (6) ◽  
pp. 45-47
Author(s):  
Zaira Kh. Kumykova ◽  
Zalina K. Batyrova ◽  
Diana A. Kruglyak ◽  
Elena V. Uvarova ◽  
Vladimir D. Chuprynin ◽  
...  

The article describe a rare clinical observation of a giant paraovarian cyst in a teenage girl with laparoscopic removal. The presence of giant cyst in the abdominal cavity in adolescent girls requires a multidisciplinary approach, taking into account visual diagnostic methods, preference for MRI, followed by the participation of experienced teams of highly qualified specialists in order to conduct a minimally invasive organ-preserving treatment.


Chirurgia ◽  
2019 ◽  
Vol 32 (5) ◽  
Author(s):  
Damiano Bisogni ◽  
Riccardo Naspetti ◽  
Luca Talamucci ◽  
Andrea Valeri ◽  
Roberto Manetti

Author(s):  
Sameer Peer ◽  
Vivek Murumkar ◽  
Karthik Kulanthaivelu ◽  
Chandrajit Prasad ◽  
Shilpa Rao ◽  
...  

Abstract Background Diffuse leptomeningeal glioneuronal tumor (DLGNT) has been recently described in the literature. The complete neuroimaging spectrum and histopathological characteristics of this entity are yet to be elucidated. In an endemic region, diffuse leptomeningeal enhancement on neuroimaging with associated communicating hydrocephalus is usually suggestive of infective meningitis and the patients are started on empirical anti-microbial therapy. However, it is important to consider other differential diagnosis of leptomeningeal enhancement in such cases, particularly if the clinical condition does not improve on anti-microbial therapy. An early diagnosis of a neoplastic etiology may be of particular importance as the treatment regimens vary considerably depending on the underlying disease condition. Case presentation In this case report, we describe a case of DLGNT with high-grade histopathological features which was initially managed as tubercular meningitis based on the initial neuroimaging findings. Due to worsening of the clinical course and subsequent imaging findings at follow-up, a diagnosis of DLGNT was considered and subsequently proven to be DLGNT with features of anaplasia on histopathological examination of leptomeningeal biopsy specimen. Conclusion This case highlights the importance of recognizing certain subtle finding on MRI which may help in an early diagnosis of DLGNT which is crucial for appropriate treatment.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sawsan Ismail ◽  
Munawar Hraib ◽  
Rana Issa ◽  
Thanaa Alassi ◽  
Zuheir Alshehabi

Abstract Background Ovarian steroid cell tumors represent a rare category of sex cord-stromal tumors that constitute less than 0.1% of all ovarian tumors. These neoplasms are classified into three main subtypes according to the cell of origin: Leidyg cell tumors, stromal luteomas, and steroid cell tumors not otherwise specified (SCTs-NOS). The latter subtype is defined as a neoplasm of an uncertain lineage that mostly affects middle-aged women, whereas it’s rare in younger ages. Case presentation We report a case of a 21-year-old virgin female who presented to our hospital with complaints of mild abdominal pain, hirsutism, and oligomenorrhea for more than a year. Before her current admission, the patient had attended an external gynecologic clinic where she had been prescribed oral contraceptives to regulate her periods. Nevertheless, on presentation to our institution, physical examination revealed abdominal tenderness with a palpable pelvic mass and mild hirsutism in the thigh. Ultrasonography demonstrated a large left ovarian mass measuring 154 × 104 mm, and compressing the uterus. Therefore, a unilateral salpingo-oophorectomy was performed, and interestingly, pathologic examination of the large aforementioned mass alongside with immunohistochemical correlation revealed the diagnosis of a large ovarian steroid cell tumor-not otherwise specified with a unique combination of benign and malignant features. Conclusions Although ovarian steroid cell tumors represent a rare category, they must be considered in the differential diagnosis for mild virilization symptoms in young females due to the importance of early diagnosis and management. In this manuscript, we aimed to present the first case report from Syria that highlights the crucial role of detailed morphological examination for challenging cases despite the difficulties in differential diagnosis, and the absence of ancillary techniques. Furthermore, we managed to discuss a brief review of diagnostic methods, histological characteristics, and treatment recommendations.


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