A retrospective analysis of pleural effusion specimens based on the newly proposed International System for Reporting Serous Fluid Cytopathology

2021 ◽  
Author(s):  
Yi Xu ◽  
Ai‐Yan Hu ◽  
Shou‐Mei Wang ◽  
Qian Wang ◽  
Yun‐Cui Pan ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Retrospective Analysis ◽  
International System ◽  
Serous Fluid

The Use of The International System for Reporting Serous Fluid Cytopathology (ISRSFC) on Patients with Pleural Effusion and Pleural Biopsy

2020 ◽  
Vol 9 (6) ◽  
pp. S7-S8
Author(s):  
Robert Jones ◽  
Ricardo Pastorello ◽  
Paul Morris ◽  
Alessandra Schmitt ◽  
Zahra Maleki ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
International System ◽  
Serous Fluid ◽  
Pleural Biopsy

scholarly journals A Retrospective Analysis of Serous Effusions Based on the Newly Proposed International System for Reporting Serous Fluid Cytopathology: A Report of 3633 Cases in an Oncological Center

2022 ◽  
Author(s):  
Yan-li Zhu ◽  
Wen-hao Ren ◽  
Qian Wang ◽  
Hai-zhu Jin ◽  
Yi-yi Guo ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Predictive Value ◽  
International System ◽  
High Specificity ◽  
Serous Effusion ◽  
Serous Fluid ◽  
Preparation Methods ◽  
Cytologic Examination ◽  
Risk Of Malignancy ◽  
The Difference

Abstract Background: The International System for Reporting Serous Fluid Cytopathology (TIS) was recently proposed. We retrospectively applied TIS recommendations for reporting the cytological diagnosis of serous effusions and reported our experience.Methods: All the serous effusions from January 2018 to September 2021 were retrieved from the database. Recategorization was performed using the TIS classification, the risk of malignancy (ROM) was calculated for each TIS category, and the performance evaluation was carried out among different samples (pleural, peritoneal and pericardial effusions) and preparation methods (conventional smears, liquid-based preparations and cell-blocks). Results: A total of 3633 cases were studied, 17 (0.5%) were diagnosed as ND, 1100 (30.3%) as NFM, 101 (2.8%) as AUS, 677 (18.6%) as SFM, and 1738 (47.8%) as MAL. The ROM for the categories were found to be 38.5%, 28.6%, 52.1%, 99.4% and 100%, respectively. The ROM for SFM was significantly higher than that for AUS (P < 0.001), while the difference between the ROMs for the IVa and IVb was insignificant. The sensitivity, negative predictive value(NPV) and diagnostic accuracy of liquid-based preparations were all superior to conventional smears and cell-blocks in detecting abnormalities. Using three preparation methods simultaneously had the highest sensitivity, NPV and diagnostic accuracy.Conclusion: Serous effusion cytology has a high specificity and positive predictive value(PPV), and the TIS is a user-friendly reporting system. Liquid-based preparations could improve the sensitivity of diagnosis, and it is best to use three different preparation methods simultaneously for serous effusion cytologic examination.

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