Unusual presentation of disseminated histoplasmosis in an immunocompetent patient

2017 ◽  
Vol 45 (9) ◽  
pp. 848-850
Author(s):  
Manju Kumari ◽  
Madhumitha Udayakumar ◽  
Manju Kaushal ◽  
Garima Baweja Madaan
Keyword(s):  
Immunocompetent Patient ◽  
Unusual Presentation ◽  
Disseminated Histoplasmosis

scholarly journals Gastrointestinal Histoplasmosis Mimicking Crohn’s Disease

2021 ◽  
Author(s):  
Esfandiar Shojaei ◽  
Joanna C Walsh ◽  
Nikhil Sangle ◽  
Brian Yan ◽  
Michael S Silverman ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Antifungal Therapy ◽  
Immunocompetent Patient ◽  
Immunocompromised Patients ◽  
Disseminated Histoplasmosis ◽  
Gastrointestinal Histoplasmosis ◽  
Life Threatening ◽  
Inflammatory Drugs ◽  
Tissue Specimens

Abstract Disseminated histoplasmosis is a life-threatening disease usually seen in immunocompromised patients living in endemic areas. We present an apparently immunocompetent patient with gastrointestinal histoplasmosis who was initially diagnosed as biopsy-proven Crohn’s disease. Following discontinuation of anti-inflammatory drugs and institution of antifungal therapy, his GI illness completely improved. Specific fungal staining should be routinely included in histopathologic assessment of tissue specimens diagnosed as Crohn’s disease.

scholarly journals Disseminated Histoplasmosis with Oral Manifestation in an Immunocompetent Patient

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Debopriya Chatterjee ◽  
Aishwarya Chatterjee ◽  
Manoj Agarwal ◽  
Meetu Mathur ◽  
Setu Mathur ◽  
...  
Keyword(s):  
Case Report ◽  
Female Patient ◽  
Immunocompetent Patient ◽  
Oral Manifestation ◽  
Disseminated Histoplasmosis

A case of disseminated histoplasmosis (DH) in a 60-year-old female patient is reported from Jaipur, Rajasthan, India. The patient presented with multiple papules on the skin surrounding the lips, face, torso, trunk, and back. She also complained of growth in the palate. Histoplasmosis was confirmed by biopsy and histopathology of skin and palatal lesions. This case report highlights the presenting features and occurrence of histoplasmosis in nonendemic region in India.

scholarly journals Disseminated Histoplasmosis in an Immunocompetent Patient After COVID-19 Pneumonia

Cureus ◽  
2021 ◽  
Author(s):  
Matthew Taylor ◽  
Arjun Ghodasara ◽  
Ali Ismail ◽  
Umair Gauhar ◽  
Karim El-Kersh
Keyword(s):  
Immunocompetent Patient ◽  
Disseminated Histoplasmosis

scholarly journals Disseminated histoplasmosis presenting as diabetic keto-acidosis in an immunocompetent patient

2017 ◽  
pp. bcr2016217915 ◽  
Author(s):  
Negin Niknam ◽  
Prashant Malhotra ◽  
Angela Kim ◽  
Seth Koenig
Keyword(s):  
Immunocompetent Patient ◽  
Disseminated Histoplasmosis

scholarly journals Typical Facial Lesions: A Window of Suspicion for Progressive Disseminated Histoplasmosis—A Case of Asian Prototype

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Prasan K. Panda ◽  
Siddharth Jain ◽  
Rita Sood ◽  
Rajni Yadav ◽  
Naval K. Vikram
Keyword(s):  
Histoplasma Capsulatum ◽  
Bone Marrow Aspiration ◽  
Febrile Illness ◽  
Immunocompetent Patient ◽  
Dimorphic Fungus ◽  
Recent Onset ◽  
Disseminated Histoplasmosis ◽  
The Face ◽  
History Of ◽  
Progressive Disseminated Histoplasmosis

Histoplasmosis is caused by a dimorphic fungusHistoplasma capsulatumin endemic areas, mainly America, Africa, and Asia. In India, it is being reported from most states; however, it is endemic along the Ganges belt. We report a case of an apparently immunocompetent male who presented with 3-month history of fever, cough, and weight loss with recent onset odynophagia and had hepatosplenomegaly and mucocutaneous lesions over the face. The differential diagnosis of leishmaniasis, tuberculosis, leprosy, fungal infection, lymphoproliferative malignancy, and other granulomatous disorders was considered, but he succumbed to his illness. Antemortem skin biopsy and bone marrow aspiration along with postmortem liver, lung, and spleen biopsy showed disseminated histoplasmosis. This case highlights the need for an early suspicion of progressive disseminated histoplasmosis in the presence of classical mucocutaneous lesions even in an immunocompetent patient suffering from a febrile illness. Cure rate approaches almost 100% with early treatment, whereas it is universally fatal if left untreated.

Sign in / Sign up

Export Citation Format

Share Document