Spindle cell lipoma with predominant nerve sheath tumor-like areas: A potential diagnostic pitfall on aspiration cytology

2015 ◽  
Vol 43 (12) ◽  
pp. 1017-1019 ◽  
Author(s):  
Sanjay Gupta ◽  
Ruchika Gupta ◽  
Pushpa Sodhani
Keyword(s):  
Spindle Cell ◽  
Nerve Sheath Tumor ◽  
Spindle Cell Lipoma ◽  
Aspiration Cytology ◽  
Diagnostic Pitfall ◽  
Nerve Sheath

scholarly journals Metastatic small cell carcinoma of the lung with prominent spindle cell morphology and hemangiopericytoma-like vascular pattern: A sarcoma mimicker

2020 ◽  
Vol 8 ◽  
pp. 2050313X2098117
Author(s):  
Esra Nsour ◽  
Ali Al Khader ◽  
Bushra Al-Tarawneh
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Spindle Cell ◽  
Small Cell ◽  
Nerve Sheath Tumor ◽  
Vascular Pattern ◽  
Nerve Sheath ◽  
History Of ◽  
Wall Mass ◽  
Aggressive Clinical Behavior

Small cell carcinoma is a malignant neuroendocrine tumor with aggressive clinical behavior. Histologically, the tumor is characterized by the proliferation of small, round, blue cells. Here, we present the case of a 50-year-old man with a 1-month history of enlarging chest wall mass. Microscopic examination of the lesion revealed a highly cellular neoplasm composed of closely packed, atypical spindle cells with scant cytoplasm, inconspicuous nucleoli, and brisk mitotic activity. The hemangiopericytoma-like vascular pattern was prominent. Areas showing a fibrosarcoma-like fascicular pattern were also observed. The tumor was immunohistochemically positive for TTF1, synaptophysin, and chromogranin, confirming small cell carcinoma. Further investigations revealed a lung origin and widespread metastases. The tumor in this case closely mimicked synovial sarcoma or malignant peripheral nerve sheath tumor. Small cell carcinoma demonstrates a hemangiopericytoma-like pattern that can mimic sarcoma histologically. This is a serious pitfall that can significantly affect the speed of diagnosis and management.

EWSR1-SMAD3-Positive Fibroblastic Tumor

2020 ◽  
pp. 106689692093812
Author(s):  
Oliver Foot ◽  
Magnus Hallin ◽  
Robin L. Jones ◽  
Vaiyapuri P. Sumathi ◽  
Khin Thway
Keyword(s):  
Spindle Cell ◽  
Soft Tissue Tumors ◽  
Spindle Cell Sarcoma ◽  
Correct Identification ◽  
Nerve Sheath Tumor ◽  
Not Otherwise Specified ◽  
Nerve Sheath ◽  
Spindle Cells ◽  
Subcutaneous Tissues ◽  
Malignant Soft Tissue

EWSR1-SMAD3-positive fibroblastic tumor is a recently characterized neoplasm with distinct clinicopathologic features and recurrent EWSR1-SMAD3 gene fusion. ESFT typically presents as a small, painless tumor in extremity subcutaneous tissues. Their behavior is benign, although they are prone to local recurrence. They typically comprise two components: intersecting fascicles of overlapping, uniform plump spindle cells, and less cellular hyalinized areas containing stippled calcifications. Immunohistochemically, the cells consistently show diffuse ERG nuclear expression, while other markers are negative. The morphology of this neoplasm can lead to histologic confusion with both benign and malignant soft tissue tumors, including monophasic synovial sarcoma, malignant peripheral nerve sheath tumor, and spindle cell sarcoma, not otherwise specified. Correct identification of ESFT is critical, most importantly to avoid unnecessary overtreatment as sarcoma.

A Rare Cause of Primary Hepatic Neoplasm: Malignant Peripheral Nerve Sheath Tumor in the Age of Modern Liver Surgery

2008 ◽  
Vol 74 (1) ◽  
pp. 47-50 ◽  
Author(s):  
Douglas M. Iddings ◽  
Byron E. Wright ◽  
Anton Bilchik
Keyword(s):  
Peripheral Nerve ◽  
Biopsy Specimen ◽  
Spindle Cell ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Spindle Cells ◽  
Clinical Diagnoses ◽  
Impact On Treatment ◽  
Hepatic Neoplasm

Primary malignant peripheral nerve sheath tumor (MPNST) of the liver is rare. Histologic identification of spindle cells from a biopsy specimen and the potential clinical diagnoses are discussed. Potential metastatic and primary spindle cell lesions, as well as their impact on treatment decisions are considered. This was successfully treated with ablation assisted surgical resection and minimal blood loss.

Recurrence of acoustic neurilemoma as a malignant spindle-cell neoplasm

1990 ◽  
Vol 73 (6) ◽  
pp. 946-950 ◽  
Author(s):  
Catriona A. McLean ◽  
John D. Laidlaw ◽  
David S. B. Brownbill ◽  
Michael F. Gonzales
Keyword(s):  
Cerebellopontine Angle ◽  
Spindle Cell ◽  
Positive Staining ◽  
Nerve Sheath Tumor ◽  
Content Type ◽  
Spindle Cell Neoplasm ◽  
Nerve Sheath ◽  
Cell Neoplasm ◽  
Acoustic Nerve ◽  
S 100

✓ A 75-year-old man presented with a right cerebellopontine angle tumor 11 months after complete macroscopic resection of a right acoustic neurilemoma. Histological examination of the recurrent tumor showed a malignant spindle-cell neoplasm with positive staining for S-100 protein. The patient had no stigmata of von Recklinghausen's disease. It is proposed that this recurrence represents progression from a benign to a malignant acoustic nerve-sheath tumor, an event that is extremely rare outside the clinicopathological context of neurofibromatosis.

Superficial malignant peripheral nerve sheath tumor with overlying intradermal melanocytic nevus mimicking spindle cell melanoma

2016 ◽  
Vol 43 (12) ◽  
pp. 1220-1225 ◽  
Author(s):  
Christopher R. Jackson ◽  
Eugen C. Minca ◽  
Jyoti P. Kapil ◽  
Steven Christopher Smith ◽  
Steven D. Billings
Keyword(s):  
Peripheral Nerve ◽  
Spindle Cell ◽  
Melanocytic Nevus ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath
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