Mammary analog secretory carcinoma of salivary gland: Cytologic diagnosis and differential diagnosis of an unreported entity

2012 ◽  
Vol 41 (3) ◽  
pp. 239-241 ◽  
Author(s):  
Latha Pisharodi
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Secretory Carcinoma ◽  
Cytologic Diagnosis ◽  
Mammary Analog Secretory Carcinoma

scholarly journals Erratum: Searching for mammary analog secretory carcinoma of salivary gland among its mimics

2014 ◽  
Vol 27 (6) ◽  
pp. 918-918 ◽  
Author(s):  
Andre Pinto ◽  
Vania Nosé ◽  
Claudia Rojas ◽  
Yao-Shan Fan ◽  
Carmen Gomez-Fernandez
Keyword(s):  
Salivary Gland ◽  
Secretory Carcinoma ◽  
Mammary Analog Secretory Carcinoma

Mammary Analog Secretory Carcinoma of Salivary Gland Origin With the ETV6 Gene Rearrangement by FISH

2012 ◽  
Vol 36 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Ashton Connor ◽  
Bayardo Perez-Ordoñez ◽  
Mary Shago ◽  
Alena Skálová ◽  
Ilan Weinreb
Keyword(s):  
Salivary Gland ◽  
Gene Rearrangement ◽  
Secretory Carcinoma ◽  
Mammary Analog Secretory Carcinoma

scholarly journals Secretory Carcinoma: A Silent Mass Increasing in the Parotid Gland

2020 ◽  
Vol 8 (C) ◽  
pp. 191-194
Author(s):  
Cheng-Chieh Lu ◽  
Chien-Jui Cheng ◽  
Yu-Chien Kao ◽  
Mei-Chien Chen
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Regional Lymph Node ◽  
Surgical Excision ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Unique Case ◽  
Complete Surgical Excision ◽  
Immunohistochemical Studies ◽  
Mammary Analog Secretory Carcinoma

BACKGROUND: Secretory carcinoma (SC) of the salivary gland, also known as mammary analog secretory carcinoma, is a rare tumor in the parotid gland. This kind of tumor is characterized by generally indolent clinical behavior and expression of a break in the ETV6 gene. CASE REPORT: We present a unique case of secretory carcinoma and show its favorable prognoses. CONCLUSION: Secretory carcinoma of the salivary gland is a low-grade carcinoma with a favorable prognosis. It has low regional lymph node and distant metastasis potential. Due to the possibility of misdiagnosis, immunohistochemical studies and FISH are suggested. The most effective treatment is complete surgical excision with negative surgical margins.

scholarly journals Secretory Carcinoma of the Parotid: Making the Correct Diagnosis of a Rare Salivary Gland Carcinoma When Molecular Biology Testing Is Not Available

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Nelson Montalvo ◽  
David Galarza ◽  
Ligia Redrobán
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Molecular Biology ◽  
Cell Carcinoma ◽  
Molecular Analysis ◽  
Correct Diagnosis ◽  
Salivary Gland Carcinoma ◽  
Secretory Carcinoma ◽  
Not Otherwise Specified ◽  
Gland Carcinoma

Secretory carcinoma (SC) is a recently described entity occurring in the salivary glands. Before its description, SC was frequently classified as acinic cell carcinoma (ACC) or adenocarcinoma, not otherwise specified. Its particular histopathological and immunohistochemical characteristics are reminiscent of breast secretory carcinoma. Moreover, it displays a characteristic t(12;15) (p13;q25) translocation that results in the ETV6-NTRK3 gene fusion. This translocation has not been reported in any other salivary gland carcinoma. Identification of the t(12;15) (p13;q25) translocation is the gold standard for diagnosis, although some cases that do not present this specific translocation have already been reported. In such cases, diagnosis is challenging. In addition, some diagnostic pathology laboratories lack the resources to perform the molecular analysis to diagnose SC. In this scenario, morphology and immunohistochemistry are fundamental. Therefore, we report a case emphasizing the typical morphology of SC and its immunochemical profile to establish a final diagnosis without molecular biology tests. This case aims to demonstrate the importance of recognizing the typical presentation of a rare tumor so that clinicians will be informed or reminded of it and consider this entity among the differential diagnoses, when necessary. Moreover, in low-resource settings where molecular analysis is not available, being familiar enough with the histology of this tumor and using the immunoprofile as a key tool for differential diagnosis would be of great importance in establishing the correct diagnosis. The differential diagnosis includes, above all, acinic cell carcinoma and other salivary neoplasms such as intraductal carcinoma, low-grade mucoepidermoid carcinoma, and adenocarcinoma, not otherwise specified, which is actually a rule-out diagnosis.

scholarly journals The cytopathologic features of mammary analog secretory carcinoma and its mimics

CytoJournal ◽  
2014 ◽  
Vol 11 ◽  
pp. 24 ◽  
Author(s):  
T. Danielle Samulski ◽  
Virginia A. LiVolsi ◽  
Zubair Baloch
Keyword(s):  
Salivary Gland ◽  
Mucoepidermoid Carcinoma ◽  
Needle Aspiration ◽  
Definite Diagnosis ◽  
Secretory Carcinoma ◽  
Warthin Tumor ◽  
Fine Needle ◽  
Monomorphic Population ◽  
Mammary Analog Secretory Carcinoma ◽  
Foamy Cytoplasm

Mammary Analogue Secretory Carcinoma (MASC) is a newly recognized neoplasm of the salivary gland, first described in 2010. This tumor harbors a unique translocation, t(12;15)(p13;q25) that results in the fusion of ETV6 with NTRK3 which produces a transformative chimeric tyrosine kinase. To date, few cases of MASC sampled by fine needle aspiration have been reported. Cytologically, MASC can be confused with other oncocytic salivary gland tumors, including Warthin-tumor, acinic cell carcinoma (AciCC) and mucoepidermoid carcinoma. It is characterized by a monomorphic population of lesional cells with round nuclei, prominent nucleoli and abundant, eosinophilic foamy cytoplasm; forming papillary groups with transgressing vessels. Though, based on cytomorphology alone, the definite diagnosis can be challenging, in conjunction with available clinical clues (i.e. male patient, extra-parotid site) MASC should be included in the differential diagnosis of FNA specimens diagnosed as oncocytic salivary gland neoplasms or suspicious for AciCC. Here we present a case of MASC with FNA sampling at our institution.

scholarly journals Searching for mammary analog secretory carcinoma of salivary gland among its mimics

2013 ◽  
Vol 27 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Andre Pinto ◽  
Vania Nosé ◽  
Claudia Rojas ◽  
Yao-Shan Fan ◽  
Carmen Gomez-Fernandez
Keyword(s):  
Salivary Gland ◽  
Secretory Carcinoma ◽  
Mammary Analog Secretory Carcinoma
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