High-risk human papillomavirus DNA testing: A marker for atypical glandular cells

2006 ◽  
Vol 34 (3) ◽  
pp. 235-239 ◽  
Author(s):  
Anjali Saqi ◽  
Prabodh K. Gupta ◽  
Maria Erroll ◽  
Anamaria Babiac ◽  
Dorothy Blackmun ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Dna Testing ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Papillomavirus Dna

Human papillomavirus DNA detection and histological findings in women referred for atypical glandular cells or adenocarcinoma in situ in their Pap smears

2004 ◽  
Vol 95 (3) ◽  
pp. 618-623 ◽  
Author(s):  
Sophie Françoise Mauricette Derchain ◽  
Silvia Helena Rabelo-Santos ◽  
Luis Otávio Sarian ◽  
Luiz Carlos Zeferino ◽  
Eliane Regina de Oliveira Zambeli ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Dna Detection ◽  
Pap Smears ◽  
Adenocarcinoma In Situ ◽  
Histological Findings ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Papillomavirus Dna

Significance of High-Risk Human Papillomavirus Testing for Atypical Glandular Cells on Cervical Cytology

2018 ◽  
Vol 62 (5-6) ◽  
pp. 405-410 ◽  
Author(s):  
Hiroaki Komatsu ◽  
Tetsuro Oishi ◽  
Daiken Osaku ◽  
Mayumi Sawada ◽  
Akiko Kudoh ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Intraepithelial Neoplasia ◽  
Adenocarcinoma In Situ ◽  
Diagnostic Significance ◽  
Predictive Values ◽  
Squamous Cells ◽  
Glandular Cells ◽  
Atypical Glandular Cells

Objectives: The aim of this study was to evaluate the diagnostic significance of high-risk human papillomavirus (hrHPV) testing for managing women with atypical glandular cells (AGC) and to explore the distribution of hrHPV genotypes. Methods: We analyzed cytologic and histopathologic diagnoses in patients referred to our institution due to AGC or atypical squamous cells of undetermined significance (ASC-US). All patients underwent hrHPV testing and genotyping, and positive (PPV) and negative predictive values (NPV) for cervical intraepithelial neoplasia (CIN) 2 or worse [CIN2+/adenocarcinoma in situ (AIS)+] were calculated. Results: Among 41 cases previously diagnosed with AGC, 22 (53%) were classified as CIN2+ (2 squamous cell carcinomas), whereas only 2 were AIS or adenocarcinoma. Twenty-seven (65.8%) cases in the AGC group were hrHPV positive. The most frequent genotypes in both the ASC-US and AGC groups were HPV16 and HPV52. The PPV of hrHPV testing for CIN2+/AIS+ was significantly higher in the AGC than in the ASC-US group (74.1 vs. 35.0%; p = 0.0005). The NPV for CIN2+/AIS+ was significantly lower in the AGC than in the ASC-US group (74.4 vs. 100%; p = 0.0441). Conclusion: In patients with AGC, both glandular and squamous lesions must be monitored. hrHPV testing is useful for detecting CIN2+/AIS+ in AGC.

scholarly journals Urine-based human papillomavirus DNA testing as a screening tool for cervical cancer in high-risk women

2013 ◽  
Vol 124 (2) ◽  
pp. 151-155 ◽  
Author(s):  
Keimari Mendez ◽  
Josefina Romaguera ◽  
Ana P. Ortiz ◽  
Mariel López ◽  
Martin Steinau ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Screening Tool ◽  
Dna Testing ◽  
High Risk Women ◽  
Papillomavirus Dna
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