Adjunctive high-risk human papillomavirus DNA testing is a useful option for disease risk assessment in patients with negative Papanicolaou tests without an endocervical/transformation zone sample

Cancer ◽  
2008 ◽  
Vol 114 (4) ◽  
pp. 242-248 ◽  
Author(s):  
Chengquan Zhao ◽  
R. Marshall Austin
Keyword(s):  
Risk Assessment ◽  
Human Papillomavirus ◽  
High Risk ◽  
Disease Risk ◽  
Dna Testing ◽  
Transformation Zone ◽  
Papillomavirus Dna

Adjunctive Human Papillomavirus DNA Testing Is a Useful Option in Some Clinical Settings for Disease Risk Assessment and Triage of Females With ASC-H Papanicolaou Test Results

2008 ◽  
Vol 132 (12) ◽  
pp. 1874-1881 ◽  
Author(s):  
Sudeshna Bandyopadhyay ◽  
R. Marshall Austin ◽  
David Dabbs ◽  
Chengquan Zhao
Keyword(s):  
Risk Assessment ◽  
Human Papillomavirus ◽  
High Risk ◽  
Disease Risk ◽  
Pap Test ◽  
Intraepithelial Neoplasia ◽  
Test Results ◽  
Dna Testing ◽  
High Risk Hpv

Abstract Context.—Recent guidelines recommend colposcopy for women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H). Objective.—To determine whether adjunctive high-risk human papillomavirus (hrHPV) testing is useful for disease risk assessment in females with ASC-H Papanicolaou (Pap) test results. Design.—High-risk HPV prevalence and histopathologic follow-up data on 1187 females with ASC-H ThinPrep Pap test (TPPT) and hrHPV test results were analyzed. Results.—ASC-H was reported in 1646 (0.006%) of 277 400 (270 338 TPPT and 7062 conventional) Pap test results. The difference in ASC-H detection rates between TPPTs and conventional Pap smears was statistically significant (0.60% vs 0.38%; P = .02). High-risk HPV was detected in 589 (49.6%) of 1187 females with ASC-H TPPT and hrHPV testing. The hrHPV DNA–positive rate in females younger than 40 years was 54.7%, significantly higher than the 36.5% in women 40 years and older. Among 505 females with histopathologic follow-up, cervical intraepithelial neoplasia 2/3 was identified in 32.7% of hrHPV-positive females compared with 1.2% in hrHPV-negative females. The sensitivity, specificity, positive predictive value, and negative predictive value of ASC-H cytology in conjunction with hrHPV DNA testing results for detection of cervical intraepithelial neoplasia 2/3 were 96.1% versus 100.0%, 54.0% versus 68.4%, 35.8% versus 20.8%, and 98.1% versus 100.0% in females younger than 40 years and women 40 years and older, respectively. Conclusions.—Our data suggest that reflex hrHPV testing is a highly useful option for women with ASC-H Pap tests. Females with ASC-H and negative hrHPV testing may be more efficiently managed by follow-up with regular Pap and hrHPV testing rather than universal colposcopy, especially for women 40 years and older.

High-risk human papillomavirus DNA testing: A marker for atypical glandular cells

2006 ◽  
Vol 34 (3) ◽  
pp. 235-239 ◽  
Author(s):  
Anjali Saqi ◽  
Prabodh K. Gupta ◽  
Maria Erroll ◽  
Anamaria Babiac ◽  
Dorothy Blackmun ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Dna Testing ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Papillomavirus Dna

scholarly journals Urine-based human papillomavirus DNA testing as a screening tool for cervical cancer in high-risk women

2013 ◽  
Vol 124 (2) ◽  
pp. 151-155 ◽  
Author(s):  
Keimari Mendez ◽  
Josefina Romaguera ◽  
Ana P. Ortiz ◽  
Mariel López ◽  
Martin Steinau ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Screening Tool ◽  
Dna Testing ◽  
High Risk Women ◽  
Papillomavirus Dna
Sign in / Sign up

Export Citation Format

Share Document