scholarly journals Risk factors and comorbidity of ICD‐11 PTSD and complex PTSD: Findings from a trauma‐exposed population based sample of adults in the United Kingdom

2019 ◽  
Vol 36 (9) ◽  
pp. 887-894 ◽  
Author(s):  
Thanos Karatzias ◽  
Philip Hyland ◽  
Aoife Bradley ◽  
Marylène Cloitre ◽  
Neil P. Roberts ◽  
...  
Keyword(s):  
Risk Factors ◽  
United Kingdom ◽  
Population Based ◽  
Complex Ptsd ◽  
The United Kingdom ◽  
Exposed Population

Risk factors for first venous thromboembolism around pregnancy: a population-based cohort study from the United Kingdom

Blood ◽  
2013 ◽  
Vol 121 (19) ◽  
pp. 3953-3961 ◽  
Author(s):  
Alyshah Abdul Sultan ◽  
Laila J. Tata ◽  
Joe West ◽  
Linda Fiaschi ◽  
Kate M. Fleming ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
United Kingdom ◽  
Preterm Birth ◽  
Venous Thromboembolism ◽  
Population Based ◽  
The United Kingdom ◽  
Key Points ◽  
Modest Effect

Key Points Antepartum, we found that established risk factors only had a modest effect on rates of VTE. Postpartum, we found that among other factors, women with stillbirth or preterm birth had high rates of VTE.

scholarly journals Augmented renal clearance: a retrospective, cohort study of urinary creatinine clearance in critically ill patients in the United Kingdom

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110155
Author(s):  
Brian W Johnston ◽  
David Perry ◽  
Martyn Habgood ◽  
Miland Joshi ◽  
Anton Krige
Keyword(s):  
Risk Factors ◽  
United Kingdom ◽  
Creatinine Clearance ◽  
Renal Clearance ◽  
Repeated Measures ◽  
Apache Ii ◽  
Apache Ii Score ◽  
Augmented Renal Clearance ◽  
Urinary Creatinine ◽  
The United Kingdom

Objective Augmented renal clearance (ARC) is associated with sub-therapeutic antibiotic, anti-epileptic, and anticoagulant serum concentrations leading to adverse patient outcomes. We aimed to describe the prevalence and associated risk factors for ARC development in a large, single-centre cohort in the United Kingdom. Methods We conducted a retrospective observational study of critically unwell patients admitted to intensive care between 2014 and 2016. Urinary creatinine clearance was used to determine the ARC prevalence during the first 7 days of admission. Repeated measures logistic regression was used to determine risk factors for ARC development. Results The ARC prevalence was 47.0% (95% confidence interval [95%CI]: 44.3%–49.7%). Age, sex, Acute Physiology and Chronic Health Evaluation (APACHE) II score, and sepsis diagnosis were significantly associated with ARC. ARC was more prevalent in younger vs. older (odds ratio [OR] 0.95 [95%CI: 0.94–0.96]), male vs. female (OR 0.32 [95%CI: 0.26–0.40]) patients with lower vs. higher APACHE II scores (OR 0.94 [95%CI: 0.92–0.96]). Conclusions This patient group probably remains unknown to many clinicians because measuring urinary creatinine clearance is not usually indicated in this group. Clinicians should be aware of the ARC risk in this group and consider measurement of urinary creatinine clearance.

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