Clinical and functional outcomes of cannabis use among individuals with anxiety disorders: A 3‐year population‐based longitudinal study

2018 ◽  
Vol 35 (6) ◽  
pp. 490-501 ◽  
Author(s):  
Daniel Feingold ◽  
Jürgen Rehm ◽  
Hagai Factor ◽  
Avigayil Redler ◽  
Shaul Lev‐Ran
Keyword(s):  
Longitudinal Study ◽  
Anxiety Disorders ◽  
Functional Outcomes ◽  
Population Based ◽  
Cannabis Use

Initiation and progression of cannabis use in a population-based Australian adolescent longitudinal study

Addiction ◽  
2000 ◽  
Vol 95 (11) ◽  
pp. 1679-1690 ◽  
Author(s):  
C. Coffey ◽  
M. Lynskey ◽  
R. Wolfe ◽  
G. C. Patton
Keyword(s):  
Longitudinal Study ◽  
Population Based ◽  
Cannabis Use

The association between cannabis use and suicidality among men and women: A population-based longitudinal study

2016 ◽  
Vol 205 ◽  
pp. 216-224 ◽  
Author(s):  
Nadav Shalit ◽  
Gal Shoval ◽  
Dan Shlosberg ◽  
Daniel Feingold ◽  
Shaul Lev-Ran
Keyword(s):  
Longitudinal Study ◽  
Population Based ◽  
Cannabis Use ◽  
Men And Women

scholarly journals Understanding the nature of association between anxiety phenotypes and anorexia nervosa: a triangulation approach

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
E. Caitlin Lloyd ◽  
Hannah M. Sallis ◽  
Bas Verplanken ◽  
Anne M. Haase ◽  
Marcus R. Munafò
Keyword(s):  
Anorexia Nervosa ◽  
Longitudinal Study ◽  
Anxiety Disorder ◽  
Anxiety Disorders ◽  
Causal Effect ◽  
Causal Effects ◽  
Observational Research ◽  
Genome Wide Association Studies ◽  
Genetic Liability ◽  
Depressed Affect

Abstract Background Evidence from observational studies suggests an association between anxiety disorders and anorexia nervosa (AN), but causal inference is complicated by the potential for confounding in these studies. We triangulate evidence across a longitudinal study and a Mendelian randomization (MR) study, to evaluate whether there is support for anxiety disorder phenotypes exerting a causal effect on AN risk. Methods Study One assessed longitudinal associations of childhood worry and anxiety disorders with lifetime AN in the Avon Longitudinal Study of Parents and Children cohort. Study Two used two-sample MR to evaluate: causal effects of worry, and genetic liability to anxiety disorders, on AN risk; causal effects of genetic liability to AN on anxiety outcomes; and the causal influence of worry on anxiety disorder development. The independence of effects of worry, relative to depressed affect, on AN and anxiety disorder outcomes, was explored using multivariable MR. Analyses were completed using summary statistics from recent genome-wide association studies. Results Study One did not support an association between worry and subsequent AN, but there was strong evidence for anxiety disorders predicting increased risk of AN. Study Two outcomes supported worry causally increasing AN risk, but did not support a causal effect of anxiety disorders on AN development, or of AN on anxiety disorders/worry. Findings also indicated that worry causally influences anxiety disorder development. Multivariable analysis estimates suggested the influence of worry on both AN and anxiety disorders was independent of depressed affect. Conclusions Overall our results provide mixed evidence regarding the causal role of anxiety exposures in AN aetiology. The inconsistency between outcomes of Studies One and Two may be explained by limitations surrounding worry assessment in Study One, confounding of the anxiety disorder and AN association in observational research, and low power in MR analyses probing causal effects of genetic liability to anxiety disorders. The evidence for worry acting as a causal risk factor for anxiety disorders and AN supports targeting worry for prevention of both outcomes. Further research should clarify how a tendency to worry translates into AN risk, and whether anxiety disorder pathology exerts any causal effect on AN.

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