THE ASSOCIATION BETWEEN DEPRESSION AND LEUKOCYTE TELOMERE LENGTH: A META-ANALYSIS

2015 ◽  
Vol 32 (4) ◽  
pp. 229-238 ◽  
Author(s):  
Nicola S. Schutte ◽  
John M. Malouff
Keyword(s):  
Telomere Length ◽  
Meta Analysis ◽  
Leukocyte Telomere Length

Leukocyte telomere length in patients with bipolar disorder: An updated meta-analysis and subgroup analysis by mood status

2018 ◽  
Vol 270 ◽  
pp. 41-49 ◽  
Author(s):  
Yu-Chi Huang ◽  
Liang-Jen Wang ◽  
Ping-Tao Tseng ◽  
Chi-Fa Hung ◽  
Pao-Yen Lin
Keyword(s):  
Bipolar Disorder ◽  
Telomere Length ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Leukocyte Telomere Length

scholarly journals The contribution of parent-to-offspring transmission of telomeres to the heritability of telomere length in humans

2018 ◽  
Author(s):  
Dayana A. Delgado ◽  
Chenan Zhang ◽  
Kathryn Demanelis ◽  
Lin S. Chen ◽  
Jianjun Gao ◽  
...  
Keyword(s):  
Telomere Length ◽  
Genetic Relatedness ◽  
Meta Analysis ◽  
Telomere Maintenance ◽  
Leukocyte Telomere Length ◽  
Relative Pair ◽  
Identity By Descent ◽  
Novel Approach ◽  
Genome Wide ◽  
Heritable Trait

ABSTRACTLeukocyte telomere length (LTL) is a heritable trait with two potential sources of heritability (h2): inherited variation in non-telomeric regions (e.g., SNPs that influence telomere maintenance) and variability in the lengths of telomeres in gametes that produce offspring zygotes (i.e., “direct” inheritance). Prior studies of LTL h2have not attempted to disentangle these two sources. Here, we use a novel approach for detecting the direct inheritance of telomeres by studying the association between identity-by-descent (IBD) sharing at chromosome ends and phenotypic similarity in LTL. We measured genome-wide SNPs and LTL for a sample of 5,069 Bangladeshi adults with substantial relatedness. For each of the 7,254 relative pairs identified, we used SNPs near the telomeres to estimate the number of chromosome ends shared IBD, a proxy for the number of telomeres shared IBD (Tshared). We then estimated the association between Tsharedand the squared pairwise difference in LTL ((ΔLTL)2) within various classes of relatives (siblings, avuncular, cousins, and distant), adjusting for overall genetic relatedness (ϕ). The association between Tsharedand (ΔLTL)2was inverse among all relative pair types. In a meta-analysis including all relative pairs (ϕ >0.05), the association between Tsharedand (ΔLTL)2(P=0.002) was stronger than the association between ϕ and (ΔLTL)2(P=0.45). Our results provide strong evidence that telomere length (TL) in parental germ cells impacts TL in offspring cells and contributes to LTL h2despite telomere “reprogramming” during embryonic development. Applying our method to larger studies will enable robust estimation of LTL h2attributable to direction transmission.

scholarly journals Leukocyte telomere length and hippocampus volume: a meta-analysis

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 1073 ◽  
Author(s):  
Gustav Nilsonne ◽  
Sandra Tamm ◽  
Kristoffer N. T. Månsson ◽  
Torbjörn Åkerstedt ◽  
Mats Lekander
Keyword(s):  
Telomere Length ◽  
Meta Analysis ◽  
Gray Matter Volume ◽  
Apoe Genotype ◽  
Telomerase Activity ◽  
Brain Parenchyma ◽  
Leukocyte Telomere Length ◽  
The One ◽  
The Relationship ◽  
Hippocampus Volume

Leukocyte telomere length has been shown to correlate to hippocampus volume, but effect estimates differ in magnitude and are not uniformly positive. This study aimed primarily to investigate the relationship between leukocyte telomere length and hippocampus gray matter volume by meta-analysis and secondarily to investigate possible effect moderators. Five studies were included with a total of 2107 participants, of which 1960 were contributed by one single influential study. A random-effects meta-analysis estimated the effect to r = 0.12 [95% CI -0.13, 0.37] in the presence of heterogeneity and a subjectively estimated moderate to high risk of bias. There was no evidence that apolipoprotein E (APOE) genotype was an effect moderator, nor that the ratio of leukocyte telomerase activity to telomere length was a better predictor than leukocyte telomere length for hippocampus volume. This meta-analysis, while not proving a positive relationship, also is not able to disprove the earlier finding of a positive correlation in the one large study included in analyses. We propose that a relationship between leukocyte telomere length and hippocamus volume may be mediated by transmigrating monocytes which differentiate into microglia in the brain parenchyma.

scholarly journals Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaofeng Xu ◽  
Haochang Hu ◽  
Ying Lin ◽  
Fangzhong Huang ◽  
Huihui Ji ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Telomere Length ◽  
Design Method ◽  
Normal Population ◽  
Meta Analysis ◽  
Cardiovascular Death ◽  
Leukocyte Telomere Length ◽  
Asian Patients ◽  
Common Causes

Coronary heart disease (CHD) is one of the most common causes of death in the world. Numerous studies have shown that as the degree of atherosclerotic disease increases, leukocyte telomere length gradually decreases. Short telomeres increase the risk of all-cause death and cardiovascular death. However, the reported results are not consistent, since the experimental design method, the measurement method, and the disease outcome are different. Therefore, we searched five major literature databases (Pubmed, Web of science, Embase, CNKI, and Wangfang) and finally included 18 eligible articles (including 5,150 patients with CHD and 9341 controls). We found that telomere length in patients with CHD was significantly shorter than that in controls, and the telomere length was inversely correlated with the severity of CHD. Subgroup analysis showed that telomere shortening was the most significant in Asian patients with CHD, in CHD patients with an average age <65 years, and in men with CHD. The mechanism of shortening the telomere length leading to the occurrence and development of CHD is worthy of further study.

Leukocyte telomere length in patients with schizophrenia: A meta-analysis

2015 ◽  
Vol 165 (2-3) ◽  
pp. 195-200 ◽  
Author(s):  
G.B. Polho ◽  
V.J. De-Paula ◽  
G. Cardillo ◽  
B. dos Santos ◽  
D.S. Kerr
Keyword(s):  
Telomere Length ◽  
Meta Analysis ◽  
Leukocyte Telomere Length

No alteration in leukocyte telomere length in schizophrenia; evidence from a meta-analysis

2019 ◽  
Vol 208 ◽  
pp. 447-448
Author(s):  
Nafiseh Omidpanah ◽  
Fatemeh Zahra Darvishi ◽  
Mostafa Saadat
Keyword(s):  
Telomere Length ◽  
Meta Analysis ◽  
Leukocyte Telomere Length
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