The effect of Avoidant Personality Disorder on the persistence of Generalized Social Anxiety Disorder in the general population: results from a longitudinal, nationally representative mental health survey

2011 ◽  
Vol 28 (3) ◽  
pp. 250-255 ◽  
Author(s):  
Brian J. Cox ◽  
Danielle L. Turnbull ◽  
Jennifer A. Robinson ◽  
Bridget F. Grant ◽  
Murray B. Stein
PLoS ONE ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. e0188024 ◽  
Author(s):  
Michael M. Havranek ◽  
Fleur Volkart ◽  
Bianca Bolliger ◽  
Sophie Roos ◽  
Maximilian Buschner ◽  
...  

2014 ◽  
Vol 45 (8) ◽  
pp. 1581-1589 ◽  
Author(s):  
K. Isomura ◽  
M. Boman ◽  
C. Rück ◽  
E. Serlachius ◽  
H. Larsson ◽  
...  

BackgroundWe aimed to provide unbiased estimates of familial risk and heritability of social anxiety disorder (SAD) and avoidant personality disorder (AVPD).MethodWe identified 18 399 individuals diagnosed with SAD and 2673 with AVPD in the Swedish National Patient Register between 1997 and 2009. Risks (odds ratios; OR) for SAD in all biological and non-biological relatives of probands, compared to relatives of unaffected individuals were calculated. We also estimated the risks for AVPD in relatives of probands with SAD.ResultsThe risk for SAD among relatives of SAD probands increased proportionally to the degree of genetic relatedness. The risks for first-degree relatives [OR 4.74, 95% confidence interval (CI) 4.28–5.25] were significantly higher than for second-degree and third-degree relatives. Second-degree relatives (OR 2.30, 95% CI 2.01–2.63) had significantly higher risk than third-degree relatives (OR 1.72, 95% CI 1.52–1.94). Relatives at similar genetic distances had similar risks for SAD, despite different degrees of shared environment. Heritability was estimated to be approximately 56%. There were no significant sex differences in the familial patterns. The risk of AVPD in relatives of SAD probands was significantly elevated, even after excluding individuals with both diagnoses (first-degree OR 3.54, second-degree OR 2.20, third-degree OR 1.62). Non-biological relatives (spouses/partners) also had elevated risks for both SAD (OR 4.01) and AVPD (OR 3.85).ConclusionsSAD clusters in families primarily due to genetic factors. SAD and AVPD are aetiologically related and may represent different expressions of the same vulnerability. The strong marital concordance observed in SAD/AVPD may indicate assortative mating but the exact mechanisms and implications require further investigation.


2012 ◽  
Vol 26 (6) ◽  
pp. 665-672 ◽  
Author(s):  
Luana Marques ◽  
Eliora Porter ◽  
Aparna Keshaviah ◽  
Mark H. Pollack ◽  
Michael Van Ameringen ◽  
...  

2016 ◽  
Vol 125 (1) ◽  
pp. 114-124 ◽  
Author(s):  
Fartein Ask Torvik ◽  
Audun Welander-Vatn ◽  
Eivind Ystrom ◽  
Gun Peggy Knudsen ◽  
Nikolai Czajkowski ◽  
...  

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