Natural remedies for anxiety disorders: potential use and clinical applications

2009 ◽  
Vol 26 (3) ◽  
pp. 259-265 ◽  
Author(s):  
Gustavo Kinrys ◽  
Eliza Coleman ◽  
Ethan Rothstein
Keyword(s):  
Anxiety Disorders ◽  
Clinical Applications ◽  
Natural Remedies ◽  
Potential Use

Potential clinical applications of circulating cell-free DNA in ovarian cancer patients

2018 ◽  
Vol 20 ◽  
Author(s):  
Ana Barbosa ◽  
Ana Peixoto ◽  
Pedro Pinto ◽  
Manuela Pinheiro ◽  
Manuel R. Teixeira
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Liquid Biopsy ◽  
Clinical Applications ◽  
Epigenetic Alterations ◽  
Cell Free Dna ◽  
Non Invasive ◽  
Free Dna ◽  
Potential Use ◽  
Circulating Cell Free Dna

AbstractCirculating cell-free DNA (cfDNA) consists of small fragments of DNA that circulate freely in the bloodstream. In cancer patients, a fraction of cfDNA is derived from tumour cells, therefore containing the same genetic and epigenetic alterations, and is termed circulating cell-free tumour DNA. The potential use of cfDNA, the so-called ‘liquid biopsy’, as a non-invasive cancer biomarker has recently received a lot of attention. The present review will focus on studies concerning the potential clinical applications of cfDNA in ovarian cancer patients.

Potential use of Internet-based screening for anxiety disorders: a pilot study

2010 ◽  
Vol 27 (11) ◽  
pp. 1006-1010 ◽  
Author(s):  
Michael Van Ameringen ◽  
Catherine Mancini ◽  
William Simpson ◽  
Beth Patterson
Keyword(s):  
Pilot Study ◽  
Anxiety Disorders ◽  
Use Of Internet ◽  
Potential Use

Integration of biosensors based on microfluidic: a review

Sensor Review ◽  
2015 ◽  
Vol 35 (2) ◽  
pp. 190-199 ◽  
Author(s):  
Amin TermehYousefi ◽  
Samira Bagheri ◽  
Nahrizul Adib
Keyword(s):  
Design Methodology ◽  
Biological Fluids ◽  
Clinical Applications ◽  
Selective Detection ◽  
Content Type ◽  
Technological Advances ◽  
Biological Studies ◽  
Reliable Monitoring ◽  
Monitoring Devices ◽  
Potential Use

Purpose – Biotechnology is closely associated to microfluidics. During the last decade, designs of microfluidic devices such as geometries and scales have been modified and improved according to the applications for better performance. Numerous sensor technologies existing in the industry has potential use for clinical applications. Fabrication techniques of microfluidics initially rooted from the electromechanical systems (EMS) technology. Design/methodology/approach – In this review, we emphasized on the most available manufacture approaches to fabricate microchannels, their applications and the properties which make them unique components in biological studies. Findings – Major fundamental and technological advances demonstrate the enhancing of capabilities and improving the reliability of biosensors based on microfluidic. Several researchers have been reported verity of methods to fabricate different devices based on EMS technology due to the electroconductivity properties and their small size of them. Therefore, controlled fabrication method of MEMS plays an important role to design and fabricate a highly selective detection of medical devices in a variety of biological fluids. Stable, tight and reliable monitoring devices for biological components still remains a massive challenge and several studies focused on MEMS to fabricate simple and easy monitoring devices. Originality/value – This paper is not submitted or under review in any other journal.

scholarly journals Potential Use of Modulators of Oxidative Stress as Add-on Therapy in Patients with Anxiety Disorders

2018 ◽  
Vol 19 (6) ◽  
pp. 636-650 ◽  
Author(s):  
Paolo Boldrini ◽  
Antonella Fusco ◽  
Ferdinando Nicoletti ◽  
Aldo Badiani ◽  
Luciano Saso
Keyword(s):  
Oxidative Stress ◽  
Anxiety Disorders ◽  
Potential Use

scholarly journals Epigenetic Alterations in Renal Cell Cancer With TKIs Resistance: From Mechanisms to Clinical Applications

2021 ◽  
Vol 11 ◽  
Author(s):  
Qinhan Li ◽  
Zhenan Zhang ◽  
Yu Fan ◽  
Qian Zhang
Keyword(s):  
Renal Cell ◽  
Kinase Inhibitors ◽  
Cell Cancer ◽  
Poor Response ◽  
Clinical Applications ◽  
Current Evidence ◽  
Epigenetic Alterations ◽  
Antitumor Therapy ◽  
Non Coding Rnas ◽  
Potential Use

The appearance of tyrosine kinase inhibitors (TKIs) has been a major breakthrough in renal cell carcinoma (RCC) therapy. Unfortunately, a portion of patients with TKIs resistance experience disease progression after TKIs therapy. Epigenetic alterations play an important role in the development of TKIs resistance. Current evidence suggests that epigenetic alterations occur frequently in RCC patients with poor response to TKIs therapy, and modulation of them could enhance the cytotoxic effect of antitumor therapy. In this review, we summarize the currently known epigenetic alterations relating to TKIs resistance in RCC, focusing on DNA methylation, non-coding RNAs (ncRNAs), histone modifications, and their interactions with TKIs treatment. In addition, we discuss application of epigenetic alteration analyses in the clinical setting to predict prognosis of patients with TKIs treatment, and the potential use of epigenetics-based therapies to surmount TKIs resistance.

scholarly journals Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics

2019 ◽  
Vol 20 (18) ◽  
pp. 4496 ◽  
Author(s):  
Celeste Caruso Bavisotto ◽  
Calogero Cipolla ◽  
Giuseppa Graceffa ◽  
Rosario Barone ◽  
Fabio Bucchieri ◽  
...  
Keyword(s):  
Molecular Chaperones ◽  
Tumor Tissue ◽  
Thyroid Tissue ◽  
Endocrine System ◽  
Clinical Applications ◽  
Benign Goiter ◽  
Ablative Surgery ◽  
Before And After ◽  
Peritumoral Tissue ◽  
Potential Use

The thyroid is a major component of the endocrine system and its pathology can cause serious diseases, e.g., papillary carcinoma (PC). However, the carcinogenic mechanisms are poorly understood and clinical useful biomarkers are scarce. Therefore, we determined if there are quantitative patterns of molecular chaperones in the tumor tissue and circulating exosomes that may be useful in diagnosis and provide clues on their participation in carcinogenesis. Hsp27, Hsp60, Hsp70, and Hsp90 were quantified by immunohistochemistry in PC, benign goiter (BG), and normal peritumoral tissue (PT). The same chaperones were assessed in plasma exosomes from PC and BG patients before and after ablative surgery, using Western blotting. Hsp27, Hsp60, and Hsp90 were increased in PC in comparison with PT and BG but no differences were found for Hsp70. Similarly, exosomal levels of Hsp27, Hsp60, and Hsp90 were higher in PC than in BG, and those in PC were higher before ablative surgery than after it. Hsp27, Hsp60, and Hsp90 show distinctive quantitative patterns in thyroid tissue and circulating exosomes in PC as compared with BG, suggesting some implication in the carcinogenesis of these chaperones and indicating their potential as biomarkers for clinical applications.

Evidence-Based Treatment for Anxiety Disorders and Depression

2021 ◽  
Keyword(s):  
Anxiety Disorders ◽  
Clinical Psychology ◽  
Clinical Applications ◽  
Cutting Edge ◽  
Evidence Based ◽  
Diverse Populations ◽  
Post Graduate ◽  
Evidence Based Treatment ◽  
Case Examples

Written by internationally recognized experts, this comprehensive CBT clinician's manual provides disorder-specific chapters and accessible pedagogical features. The cutting-edge research, advanced theory, and attention to special adaptations make this an appropriate reference text for qualified CBT practitioners, students in post-graduate CBT courses, and clinical psychology doctorate students. The case examples demonstrate clinical applications of specific interventions and explain how to adapt CBT protocols for a range of diverse populations. It strikes a balance between core, theoretical principles and protocol-based interventions, simulating the experience of private supervision from a top expert in the field.

scholarly journals Metal-Phenolic Network-Coated Hyaluronic Acid Nanoparticles for pH-Responsive Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 636 ◽  
Author(s):  
Jung Min Shin ◽  
Gwan Hyun Choi ◽  
Seok Ho Song ◽  
Hyewon Ko ◽  
Eun Sook Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Targeted Drug Delivery ◽  
Drug Carrier ◽  
Clinical Applications ◽  
Targeted Cancer Therapy ◽  
Ph Responsive ◽  
Tumor Microenvironments ◽  
Rapid Release ◽  
Potential Use

Although self-assembled nanoparticles (SNPs) have been used extensively for targeted drug delivery, their clinical applications have been limited since most of the drugs are released into the blood before they reach their target site. In this study, metal-phenolic network (MPN)-coated SNPs (MPN-SNPs), which consist of an amphiphilic hyaluronic acid derivative, were prepared to be a pH-responsive nanocarrier to facilitate drug release in tumor microenvironments (TME). Due to their amphiphilic nature, SNPs were capable of encapsulating doxorubicin (DOX), chosen as the model anticancer drug. Tannic acid and FeCl3 were added to the surface of the DOX-SNPs, which allowed them to be readily coated with MPNs as the diffusion barrier. The pH-sensitive MPN corona allowed for a rapid release of DOX and effective cellular SNP uptake in the mildly acidic condition (pH 6.5) mimicking TME, to which the hyaluronic acid was exposed to facilitate receptor-mediated endocytosis. The DOX-loaded MPN-SNPs exhibited a higher cytotoxicity for the cancer cells, suggesting their potential use as a drug carrier in targeted cancer therapy.

scholarly journals Trauma Ultrasound in Civilian Tactical Medicine

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Lori Whelan ◽  
William Justice ◽  
Jeffrey M. Goodloe ◽  
Jeff D. Dixon ◽  
Stephen H. Thomas
Keyword(s):  
Decision Making ◽  
Law Enforcement ◽  
Emergency Medical Services ◽  
Hospital Setting ◽  
Clinical Applications ◽  
Medical Services ◽  
Medical Support ◽  
Emergency Medical ◽  
Tactical Medicine ◽  
Potential Use

The term “tactical medicine” can be defined in more than one way, but in the nonmilitary setting the term tactical emergency medical services (TEMS) is often used to denote medical support operations for law enforcement. In supporting operations involving groups such as special weapons and tactics (SWAT) teams, TEMS entail executing triage, diagnosis, stabilization, and evacuation decision-making in challenging settings. Ultrasound, now well entrenched as a part of trauma evaluation in the hospital setting, has been investigated in the prehospital arena and may have utility in TEMS. This paper addresses potential use of US in the tactical environment, with emphasis on the lessons of recent years’ literature. Possible uses of US are discussed, in terms of both specific clinical applications and also with respect to informing triage and related decision making.

scholarly journals Applications of PEDOT in bioelectronic medicine

2019 ◽  
Vol 2 (2) ◽  
pp. 89-99 ◽  
Author(s):  
Christian Boehler ◽  
Zaid Aqrawe ◽  
Maria Asplund
Keyword(s):  
Large Scale ◽  
New Technologies ◽  
Short Review ◽  
Polymer Coatings ◽  
Clinical Applications ◽  
Point Of View ◽  
Bioelectronic Medicine ◽  
Stability Point ◽  
Potential Use ◽  
Functional Versatility

The widespread use of conducting polymers, especially poly(3,4-ethylene dioxythiophene) (PEDOT), within the space of bioelectronics has enabled improvements, both in terms of electrochemistry and functional versatility, of conventional metallic electrodes. This short review aims to provide an overview of how PEDOT coatings have contributed to functionalizing existing bioelectronics, the challenges which meet conducting polymer coatings from a regulatory and stability point of view and the possibilities to bring PEDOT-based coatings into large-scale clinical applications. Finally, their potential use for enabling new technologies for the field of bioelectronics as biodegradable, stretchable and slow-stimulation materials will be discussed.

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