scholarly journals High-throughput linear optical stretcher for mechanical characterization of blood cells

2015 ◽  
Vol 89 (4) ◽  
pp. 391-397 ◽  
Author(s):  
Kevin B. Roth ◽  
Keith B. Neeves ◽  
Jeff Squier ◽  
David W. M. Marr
Keyword(s):  
High Throughput ◽  
Blood Cells ◽  
Mechanical Characterization ◽  
Optical Stretcher ◽  
Linear Optical

Development of microfluidic structures for high throughput flow cy-tometric characterization of blood cells

2007 ◽  
Author(s):  
A. Kummrow ◽  
H. Yildirim ◽  
J. Theisen ◽  
K. Brattke ◽  
C. Sprenger ◽  
...  
Keyword(s):  
High Throughput ◽  
Blood Cells

High-throughput mechanical characterization of free-standing polymer films

2005 ◽  
Vol 76 (6) ◽  
pp. 062214 ◽  
Author(s):  
Joe-Lahai Sormana ◽  
Santanu Chattopadhyay ◽  
J. Carson Meredith
Keyword(s):  
High Throughput ◽  
Polymer Films ◽  
Mechanical Characterization ◽  
Free Standing

Development of microfluidic structures for high throughput flow cytometric characterization of blood cells

2007 ◽  
Author(s):  
A. Kummrow ◽  
H. Yildirim ◽  
J. Theisen ◽  
K. Brattke ◽  
C. Sprenger ◽  
...  
Keyword(s):  
High Throughput ◽  
Blood Cells ◽  
Flow Cytometric

scholarly journals High-throughput microfluidic characterization of erythrocyte shape and mechanical variability

2018 ◽  
Author(s):  
Felix Reichel ◽  
Johannes Mauer ◽  
Ahmad Ahsan Nawaz ◽  
Gerhard Gompper ◽  
Jochen Guck ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Red Blood Cells ◽  
High Throughput ◽  
Blood Cells ◽  
Microvascular Blood Flow ◽  
Flow Conditions ◽  
Wide Range ◽  
Single Well ◽  
Good Agreement

The motion of red blood cells (RBCs) in microchannels is important for microvascular blood flow and biomedical applications such as blood analysis in microfluidics. The current understanding of the complexity of RBC shapes and dynamics in microchannels is mainly based on several simulation studies, but there are a few systematic experimental investigations. Here, we present a combined study, which systematically characterizes RBC behavior for a wide range of flow rates and channel sizes. Even though simulations and experiments generally show good agreement, experimental observations demonstrate that there is no single well-defined RBC state for fixed flow conditions, but rather a broad distribution of states. This result can be attributed to the inherent variability in RBC mechanical properties, which is confirmed by a model that takes the variation in RBC shear elasticity into account. This represents a significant step toward a quantitative connection between RBC behavior in microfluidic devices and their mechanical properties, which is essential for a high-throughput characterization of diseased cells.Significance StatementThe ability to change shape is crucial for the proper functioning of red blood cells under harsh conditions in the microvasculature, since their shapes strongly affect the flow behavior of whole blood. Our results from simulations and systematic experiments reveal the shapes and dynamics of red blood cells for different flow conditions and channel dimensions, generally in good agreement. However, in the experiments, cells do not exhibit a single well-defined shape for fixed flow conditions. We show that this distribution of shapes can be attributed to the variability in mechanical properties of red blood cells.

scholarly journals A high throughput array microscope for the mechanical characterization of biomaterials

2015 ◽  
Vol 86 (2) ◽  
pp. 023711 ◽  
Author(s):  
Jeremy Cribb ◽  
Lukas D. Osborne ◽  
Joe Ping-Lin Hsiao ◽  
Leandra Vicci ◽  
Alok Meshram ◽  
...  
Keyword(s):  
High Throughput ◽  
Mechanical Characterization

Self-referencing digital holographic microscopes for bio-physical and bio-mechanical characterization of blood cells

2021 ◽  
Author(s):  
Chetna Patel ◽  
Viral Kapadia ◽  
Vani Chhaniwal ◽  
Bahram Javidi ◽  
Arun Anand
Keyword(s):  
Blood Cells ◽  
Mechanical Characterization

scholarly journals Spectroscopical and mechanical characterization of normal and thalassemic red blood cells by Raman Tweezers

2008 ◽  
Vol 16 (11) ◽  
pp. 7943 ◽  
Author(s):  
Anna Chiara De Luca ◽  
Giulia Rusciano ◽  
Rosanna Ciancia ◽  
Vincenzo Martinelli ◽  
Giuseppe Pesce ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Mechanical Characterization
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