scholarly journals Integrative genomic analysis reveals a conserved role for prolactin signalling in the regulation of adrenal function

2021 ◽  
Vol 11 (11) ◽  
Author(s):  
Carmen Ruggiero ◽  
Barbara Altieri ◽  
Edith Arnold ◽  
Lourdes Siqueiros‐Marquez ◽  
Mabrouka Doghman‐Bouguerra ◽  
...  
Keyword(s):  
Genomic Analysis ◽  
Adrenal Function

Genomic analysis of C-type lectins

2002 ◽  
Vol 69 ◽  
pp. 59-72 ◽  
Author(s):  
Kurt Drickamer ◽  
Andrew J. Fadden
Keyword(s):  
Biological Effects ◽  
Cell Signalling ◽  
Genomic Analysis ◽  
Binding Activity ◽  
Immunoglobulin Superfamily ◽  
Carbohydrate Binding ◽  
Carbohydrate Recognition ◽  
Calcium Dependent ◽  
Binding Domains ◽  
Carbohydrate Recognition Domains

Many biological effects of complex carbohydrates are mediated by lectins that contain discrete carbohydrate-recognition domains. At least seven structurally distinct families of carbohydrate-recognition domains are found in lectins that are involved in intracellular trafficking, cell adhesion, cell–cell signalling, glycoprotein turnover and innate immunity. Genome-wide analysis of potential carbohydrate-binding domains is now possible. Two classes of intracellular lectins involved in glycoprotein trafficking are present in yeast, model invertebrates and vertebrates, and two other classes are present in vertebrates only. At the cell surface, calcium-dependent (C-type) lectins and galectins are found in model invertebrates and vertebrates, but not in yeast; immunoglobulin superfamily (I-type) lectins are only found in vertebrates. The evolutionary appearance of different classes of sugar-binding protein modules parallels a development towards more complex oligosaccharides that provide increased opportunities for specific recognition phenomena. An overall picture of the lectins present in humans can now be proposed. Based on our knowledge of the structures of several of the C-type carbohydrate-recognition domains, it is possible to suggest ligand-binding activity that may be associated with novel C-type lectin-like domains identified in a systematic screen of the human genome. Further analysis of the sequences of proteins containing these domains can be used as a basis for proposing potential biological functions.

EVALUATION OF PITUITARY ADRENAL FUNCTION IN CHILDREN

1964 ◽  
Vol 45 (3_Suppl) ◽  
pp. S13
Author(s):  
D. de Wied ◽  
T. Wiegman ◽  
B. van der Wal ◽  
]. F. Janssen ◽  
A. Delver
Keyword(s):  
Adrenal Function

IMPAIRMENT OF THE PITUITARY-ADRENAL AXIS FOLLOWING PROLONGED THERAPY WITH CORTICOTROPHIN

1970 ◽  
Vol 65 (4) ◽  
pp. 608-616 ◽  
Author(s):  
M. J. Levell ◽  
S. R. Stitch ◽  
M. J. Noronha
Keyword(s):  
Multiple Sclerosis ◽  
Adrenal Function ◽  
Withdrawal Symptoms ◽  
Prolonged Therapy ◽  
Adrenal Axis ◽  
Lysine Vasopressin ◽  
Subsequent Response ◽  
Pituitary Adrenal Axis

ABSTRACT Pituitary-adrenal function was tested in a group of 33 patients with multiple sclerosis who had been treated with corticotrophin for at least 1 year. Assessment was made by measuring the change in the plasma 11-hydroxycorticosteroid concentration following lysine vasopressin (LVP) administration. Ten patients showed abnormally small increases after LVP. Two of the 5 patients with the smallest increases still showed impairment 8 months later. The patients with no withdrawal symptoms had normal or nearly normal increases following LVP. There was an association between the concentration of 11-hydroxycorticosteroids immediately after withdrawal of ACTH and the subsequent response to LVP.

PITUITARY-ADRENAL FUNCTION IN RATS FOLLOWING LONG-TERM CORTISOL TREATMENT

1969 ◽  
Vol 61 (1_Suppl) ◽  
pp. S113
Author(s):  
J. R. Hodges ◽  
Janet Sadow
Keyword(s):  
Adrenal Function

DETERMINATION OF BLOOD CORTICOIDS USING THE IN VITRO RESIN UPTAKE OF 3H-PREDNISOLONE

1968 ◽  
Vol 57 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Hironori Nakajima ◽  
Mitsunori Murala ◽  
Masumitsu Nakata ◽  
Takeshi Naruse ◽  
Seiji Kubo
Keyword(s):  
Thyroid Function Test ◽  
Normal Subjects ◽  
Adrenal Function ◽  
Function Test ◽  
Before And After ◽  
Adrenal Response ◽  
Suppression Test

ABSTRACT The in vitro resin uptake of 3H-prednisolone was used for the determination of blood cortisol after addition of radioactive prednisolone followed by Amberlite CG 400 Type 1 to the test serum, and incubation of the mixture. The radioactivity of the supernatant was compared before and after the addition of the resin. The principle of this method is similar to that of the 131I-triiodothyronine resin uptake for the thyroid function test. The tests for the specificity, reproducibility and sensitivity gave satisfactory results. The mean basal value ± SD of the 3H-prednisolone resin uptake was 35.3 ± 9.2% in normal subjects, and 27.1 ± 4.8% in pregnant women. This method was valid in various adrenal function tests, i. e. the adrenal circadian rhythm, corticotrophin (ACTH) test, dexamethasone suppression test and the adrenal response to lysine-8-vasopressin. It proved to be a sensitive indicator of the adrenal function. These results suggest that this method should be useful for a routine adrenal function test.

Late onset autosomal dominant hypophosphatemic rickets; confirmation of the diagnosis with genomic analysis

2013 ◽  
Author(s):  
Symeon Tournis ◽  
Ioannis Stathopoulos ◽  
Kalliopi Lampropoulou-Adamidou ◽  
Theodora Koromila ◽  
Nikolaos Chatzistamatas ◽  
...  
Keyword(s):  
Autosomal Dominant ◽  
Late Onset ◽  
Genomic Analysis ◽  
Hypophosphatemic Rickets ◽  
Autosomal Dominant Hypophosphatemic Rickets
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