scholarly journals Root coverage stability: A systematic overview of controlled clinical trials with at least 5 years of follow‐up

2021 ◽  
Author(s):  
Kristina Bertl ◽  
Loukia M. Spineli ◽  
Khalid Mohandis ◽  
Andreas Stavropoulos
Keyword(s):  
Clinical Trials ◽  
Root Coverage ◽  
Controlled Clinical Trials ◽  
Systematic Overview

scholarly journals Intra-articular injections with corticosteroids and sodium hyaluronate for treating temporomandibular joint disorders: a systematic review

2013 ◽  
Vol 18 (5) ◽  
pp. 128-133 ◽  
Author(s):  
Eduardo Machado ◽  
Daniel Bonotto ◽  
Paulo Afonso Cunali
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Temporomandibular Joint ◽  
Sodium Hyaluronate ◽  
Temporomandibular Joint Disorders ◽  
Controlled Clinical Trials ◽  
Double Blind ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled

INTRODUCTION: In some cases, conservative treatment of internal derangements of the Temporomandibular Joint (TMJ) is considered little responsive. Thus, it is necessary to accomplish treatments that aim at reducing pain and improve patients' functions who present arthrogenic temporomandibular disorders. OBJECTIVE: This study, by means of a systematic review of the literature, aimed to analyze the effectiveness of intra-articular injections with corticosteroids and sodium hyaluronate for treating internal derangements of the TMJ. METHODS: Carry out a research in the following databases: MEDLINE, Cochrane, EMBASE, Pubmed, Lilacs, and BBO, considering publications issued between 1966 and October of 2010, focusing on randomized or quasi-randomized controlled clinical trials, single or double-blind. RESULTS: After applying the inclusion criteria we collected 9 articles, 7 of which were randomized controlled double-blind clinical trials and 2 randomized controlled single-blind clinical trials. CONCLUSION: After analyzing the literature, it was found that intra-articular injection with corticosteroids and sodium hyaluronate seems to be an effective method for treating internal derangements of the TMJ. However, further randomized controlled clinical trials, with representative samples and longer follow-up time must be carried out in order to assess the real effectiveness of this technique.

A Noninterventional Study Documenting Use and Success of Implants With a New Chemically Modified Titanium Surface in Daily Dental Practice

2010 ◽  
Vol 36 (4) ◽  
pp. 305-314 ◽  
Author(s):  
Giuseppe Luongo ◽  
Giacomo Oteri
Keyword(s):  
Clinical Trials ◽  
Titanium Surface ◽  
Dental Practice ◽  
Success Rates ◽  
Controlled Clinical Trials ◽  
Chemically Modified ◽  
Modified Surface ◽  
Noninterventional Study ◽  
Augmentation Procedure

Abstract A new chemically modified titanium surface, SLActive, has recently been developed. The results obtained in controlled clinical trials indicate that this implant can be safely used and that it offers predictable results. The goal of this noninterventional study was to verify that the success rates of implants used in daily dental practice are comparable to those reported in controlled clinical trials. This study was a prospective, noninterventional study using implants with a chemically modified surface according to the daily dental practice procedures applied by private practitioners. The choice of the implantation procedure and the loading protocol were the responsibility of the investigator and were chosen according to the patient's needs. Thirty clinical centers actively participated in this study, and 226 patients were treated, of which, 8 patients were lost to follow-up. Because of the noninterventional design of the study, the patients were not selected according to strictly defined inclusion/exclusion criteria. Thus, the study included individuals with risk factors such as smoking (24%), untreated gingivitis or periodontitis (9%), and bruxism (6%). The implants were equally distributed between mandible (46%) and maxilla (54%). A bone augmentation procedure was done in 31% of the cases. Early loading (functional loading between 48 hours and 3 months after implant insertion) was applied most frequently (48%), followed by the conventional loading protocol (3 to 6 months after implant placement, 34%). Immediate restoration and immediate loading were rare (7% and 2%, respectively). Of 276 implants inserted and documented, 5 implants failures were reported, all of which were associated with a sinus floor augmentation procedure. The survival rate was 98.2% at the 1-year follow-up visit. The results showed that implants with a chemically modified surface can be successfully restored with success rates similar to those reported in formal clinical trials under more controlled conditions.

Anxiety and Its Treatment in the Elderly

1999 ◽  
Vol 11 (1) ◽  
pp. 25-45 ◽  
Author(s):  
Christopher Krasucki ◽  
Robert Howard ◽  
Anthony Mann
Keyword(s):  
Clinical Trials ◽  
Serotonin Receptor ◽  
Research Evidence ◽  
The Elderly ◽  
Controlled Clinical Trials ◽  
New Agents ◽  
Psychological Therapies ◽  
Quality Of Life Measures

A search for references relating to the treatment of anxiety disorders in the elderly was made using the BIDS computerized database back to 1981, the Medline computerized database back to 1983, and the PsycLIT computerized database back to 1974, together with a search of relevant citations. The profusion of clinical recommendations was found to contrast with the lack of adequate supporting controlled clinical trials. There was evidence of a trend away from the benzodiazepine class of anxiolytics and an upsurge in interest in agents active at the serotonin receptor, although with the possible exception of buspirone, there is so far little research evidence for advocating use of the new agents in the elderly. Psychological therapies may be useful for many types of anxiety in the elderly, but their efficacy is also as yet unproven. Rational prescribing recommendations for anxiety in this age group will require controlled clinical trials incorporating a multiaxial approach to anxiety assessment, quality-of-life measures, psychological and placebo controls, and adequate follow-up intervals.

Home-Based Behavioral Treatments for chronic Benign Headache

Cephalalgia ◽  
1997 ◽  
Vol 17 (2) ◽  
pp. 113-118 ◽  
Author(s):  
C Keith Haddock ◽  
AB Rowan ◽  
F Andrasik ◽  
PG Wilson ◽  
G Wayne Talcott ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Meta Analysis ◽  
Future Research ◽  
Controlled Clinical Trials ◽  
Home Study ◽  
Study Materials ◽  
Home Based ◽  
Behavioral Treatments ◽  
Quantitative Analyses

Controlled clinical trials have consistently demonstrated that behavioral treatments for chronic benign headache produce clinically beneficial outcomes both post-treatment and at follow-up. Given these results there is interest in cost-reduction and redesign of these treatments to improve their accessibility. One promising approach in this regard is home-based headache treatment. These treatments seek to provide the same amount of treatment as clinic-based treatments; however, some of the material typically presented to the patient by a clinician is presented through home-study materials (e.g., manuals, audiotapes). To date, the published literature contains 20 controlled clinical trials which have examined the outcomes produced by home-based treatments. This article presents the first comprehensive meta-analysis of these clinical outcome studies. Results of the quantitative analyses suggest that home-based treatments produce comparable, or with certain outcome measures, superior results to clinic-based treatments. Moreover, cost-effectiveness scores of home-based treatments were found to be more than five times larger than those of clinic-based therapies. Methodological analyses are also presented along with suggestions for future research.

scholarly journals A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy

2020 ◽  
Author(s):  
Jason B Luoma
Keyword(s):  
Mental Health ◽  
Clinical Trials ◽  
Effect Size ◽  
Monoamine Oxidase Inhibitor ◽  
Health Conditions ◽  
Control Group ◽  
Placebo Control ◽  
Controlled Clinical Trials ◽  
Mental Health Conditions

After a two-decade hiatus in which research on psychedelics was essentially halted, placebo-controlled clinical trials of psychedelic-assisted therapy for mental health conditions have begun to be published. We identified nine randomized, placebo-controlled clinical trials of psychedelic-assisted therapy published since 1994. Studies examined psilocybin, LSD (lysergic acid diethylamide), ayahuasca (which contains a combination of N,N-dimethyltryptamine and harmala monoamine oxidase inhibitor alkaloids), and MDMA (3,4-methylenedioxymethamphetamine). We compared the standardized mean difference between the experimental and placebo control group at the primary endpoint. Results indicated a significant mean between-groups effect size of 1.21 (Hedges g), which is larger than the typical effect size found in trials of psychopharmacological or psychotherapy interventions. For the three studies that maintained a placebo control through a follow-up assessment, effects were generally maintained at follow-up. Overall, analyses support the efficacy of psychedelic-assisted therapy across four mental health conditions—post-traumatic stress disorder, anxiety/depression associated with a life-threatening illness, unipolar depression, and social anxiety among autistic adults. While study quality was high, we identify several areas for improvement regarding the conduct and reporting of trials. Larger trials with more diverse samples are needed to examine possible moderators and mediators of effects, and to establish whether effects are maintained over time.

scholarly journals A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy

2020 ◽  
Author(s):  
Jason B Luoma ◽  
Christina Chwyl ◽  
Geoff Bathje ◽  
Alan K. Davis ◽  
Rafael Lancelotta
Keyword(s):  
Mental Health ◽  
Clinical Trials ◽  
Effect Size ◽  
Monoamine Oxidase Inhibitor ◽  
Health Conditions ◽  
Control Group ◽  
Placebo Control ◽  
Controlled Clinical Trials ◽  
Mental Health Conditions

After a two-decade hiatus in which research on psychedelics was essentially halted, placebo-controlled clinical trials of psychedelic-assisted therapy for mental health conditions have begun to be published. We identified nine randomized, placebo-controlled clinical trials of psychedelic-assisted therapy published since 1994. Studies examined psilocybin, LSD (lysergic acid diethylamide), ayahuasca (which contains a combination of N,N-dimethyltryptamine and harmala monoamine oxidase inhibitor alkaloids), and MDMA (3,4-methylenedioxymethamphetamine). We compared the standardized mean difference between the experimental and placebo control group at the primary endpoint. Results indicated a significant mean between-groups effect size of 1.21 (Hedges g), which is larger than the typical effect size found in trials of psychopharmacological or psychotherapy interventions. For the three studies that maintained a placebo control through a follow-up assessment, effects were generally maintained at follow-up. Overall, analyses support the efficacy of psychedelic-assisted therapy across four mental health conditions—post-traumatic stress disorder, anxiety/depression associated with a life-threatening illness, unipolar depression, and social anxiety among autistic adults. While study quality was high, we identify several areas for improvement regarding the conduct and reporting of trials. Larger trials with more diverse samples are needed to examine possible moderators and mediators of effects, and to establish whether effects are maintained over time.

scholarly journals Lung Cancer–Related Mortality With Inhaled Insulin or a Comparator: Follow-Up Study of patients previously enrolled in Exubera Controlled Clinical Trials (FUSE) Final Results

Diabetes Care ◽  
2019 ◽  
Vol 42 (9) ◽  
pp. 1708-1715 ◽  
Author(s):  
Nicolle M. Gatto ◽  
Daniel O. Koralek ◽  
Michael B. Bracken ◽  
William T. Duggan ◽  
Joanna Lem ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Trials ◽  
Controlled Clinical Trials ◽  
Inhaled Insulin ◽  
Follow Up Study ◽  
Related Mortality

scholarly journals Root Coverage for Single Deep Gingival Recessions: Outcomes Based on a Decision-Making Algorithm

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
João B. César Neto ◽  
Marília C. Cavalcanti ◽  
Ricardo T. Sekiguchi ◽  
Claudio M. Pannuti ◽  
Giuseppe A. Romito ◽  
...  
Keyword(s):  
Decision Making ◽  
Clinical Trials ◽  
Class Ii ◽  
Class Iii ◽  
Root Coverage ◽  
Coronally Advanced Flap ◽  
Connective Tissue Graft ◽  
Keratinized Tissue ◽  
Practical Implications

Aim. The aim of this study is to report root coverage outcomes in single deep gingival recessions (GR) following a proposed decision-making algorithm. Materials and Methods. A retrospective, practice-based study included single deep (≥5 mm) Miller Class II and III defects. The step-by-step decision-making algorithm led to a choice among three different flap designs (coronally advanced flap (CAF), double papilla envelope flap (DPE) or modified lateral sliding flap (LSF)) used with a connective tissue graft. Recession depth (RD) at 6 months follow-up and the corresponding root coverage (RC) were the primary outcomes assessed. Results. Sixteen GR defects were included, with baseline RD of 6.7 ± 1.8 mm. Six months postoperatively, RD was significantly reduced to 1.2 ± 0.8 mm (p<0.05). Mean RC was 81.7 ± 13.0%, without significant differences between Miller Class II (87.1 ± 9.2%; n=9) and Class III (74.6 ± 14.5%; n=7) GRs (p=0.07). Postoperatively, keratinized tissue width increase was greater for LSF (3.5 ± 1.1) and DPE (4.2 ± 1.4 mm) than for CAF (1.9 ± 0.9 mm). Conclusions. Following the proposed decision-making algorithm, root coverage outcomes for GR defects ≥5 mm were comparable to outcomes reported for shallow defects. Prospective clinical trials are needed to validate the proposed approach and techniques. Practical Implications. The proposed algorithm allows the clinician to select the appropriate surgical technique for treatment of single deep gingival recessions with good predictability.

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