scholarly journals Performance of Plasma Coproporphyrin I and III as OATP1B1 Biomarkers in Humans

2021 ◽  
Author(s):  
Mikko Neuvonen ◽  
Aleksi Tornio ◽  
Päivi Hirvensalo ◽  
Janne T. Backman ◽  
Mikko Niemi
Keyword(s):  
Coproporphyrin I

scholarly journals Relationship of Hemoglobin Level and Plasma Coproporphyrin‐I Concentrations as an Endogenous Probe for Phenotyping OATP1B

2021 ◽  
Author(s):  
Yosuke Suzuki ◽  
Yuri Sasamoto ◽  
Teruhide Koyama ◽  
Chisato Yoshijima ◽  
Ayako Oda ◽  
...  
Keyword(s):  
Hemoglobin Level ◽  
Relationship Of ◽  
Coproporphyrin I

scholarly journals Comprehensive Evaluation of the Utility of 20 Endogenous Molecules as Biomarkers of OATP1B Inhibition Compared with Rosuvastatin and Coproporphyrin I

2018 ◽  
Vol 368 (1) ◽  
pp. 125-135 ◽  
Author(s):  
Shelby Barnett ◽  
Kayode Ogungbenro ◽  
Karelle Ménochet ◽  
Hong Shen ◽  
W. Griffith Humphreys ◽  
...  
Keyword(s):  
Comprehensive Evaluation ◽  
Coproporphyrin I

Development of an LC–MS method to quantify coproporphyrin I and III as endogenous biomarkers for drug transporter-mediated drug-drug interactions

2018 ◽  
Vol 1073 ◽  
pp. 80-89 ◽  
Author(s):  
Emmanuel Njumbe Ediage ◽  
Lieve Dillen ◽  
Ann Vroman ◽  
Luc Diels ◽  
Annett Kunze ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Drug Transporter ◽  
Coproporphyrin I

scholarly journals Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III

2020 ◽  
Vol 376 (1) ◽  
pp. 29-39
Author(s):  
Sagnik Chatterjee ◽  
Sambuddho Mukherjee ◽  
L.V.J. Sankara Sivaprasad ◽  
Tanvi Naik ◽  
Shashyendra Singh Gautam ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Coproporphyrin I

scholarly journals High-performance liquid chromatography of coproporphyrin isomers

1983 ◽  
Vol 209 (2) ◽  
pp. 553-555 ◽  
Author(s):  
D J Wright ◽  
J M Rideout ◽  
C K Lim
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Reversed Phase ◽  
Phase System ◽  
Preparative Separation ◽  
Retention Behaviour ◽  
Coproporphyrin Isomers ◽  
Coproporphyrin I

A reversed-phase system is described for the simultaneous isocratic separation of coproporphyrin I, II, III and IV isomers. The retention behaviour of coproporphyrin I and III is studied in detail. The method is suitable for both analytical and semi-preparative separation.

Prototype Application of a Robot in the Clinical Laboratory Enabling Fully Automated Quantification of Fecal Porphyrins

1992 ◽  
Vol 38 (4) ◽  
pp. 516-521 ◽  
Author(s):  
E I Minder ◽  
J P Vuilleumier ◽  
D J Vonderschmitt
Keyword(s):  
Return On Investment ◽  
Clinical Laboratory ◽  
Protoporphyrin Ix ◽  
Manual Operation ◽  
Automated Quantification ◽  
Reference Limits ◽  
Full Capacity ◽  
Chromatographic Procedure ◽  
Present Characteristic ◽  
Coproporphyrin I

Abstract Unpleasant specimens, sensitive analytes, and a lengthy chromatographic procedure were the main reasons we implemented fecal porphyrin analysis with a laboratory robot. We describe the system in detail and compare it with the same technique performed manually. The day-to-day variation of assays of standards was lower with the robot than with the manual operation: 8% (CV) for coproporphyrin I and 11% for protoporphyrin IX. We repeatedly analyzed a specimen from a healthy volunteer and determined that the specimen contained (in nmol/g dry wt) 7.1 (SD 0.7) for coproporphyrin I, 3.0 (SD 0.4) for coproporphyrin III, and 44.4 (SD 4.3) for protoporphyrin IX. Upper reference limits as measured in 20 healthy volunteers were 20 nmol/g dry wt for coproporphyrin I, 12 nmol/g for coproporphyrin III, and 80 nmol/g for protoporphyrin IX. We also present characteristic chromatograms for samples from various different porphyrias that exhibit abnormal fecal porphyrin excretion. Calculations of return on investment show that the robot, working at full capacity, is a profitable tool.

scholarly journals Substantially Increased Plasma Coproporphyrin‐I Concentrations Associated With OATP1B1*15 Allele in Japanese General Population

2020 ◽  
Author(s):  
Yosuke Suzuki ◽  
Yuri Sasamoto ◽  
Teruhide Koyama ◽  
Chisato Yoshijima ◽  
Masahiro Nakatochi ◽  
...  
Keyword(s):  
General Population ◽  
Japanese General Population ◽  
Coproporphyrin I
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