Biomarkers and Precision Therapy for Primary Immunodeficiencies: An In Vitro Study Based on Induced Pluripotent Stem Cells From Patients

2020 ◽  
Vol 108 (2) ◽  
pp. 358-367 ◽  
Author(s):  
Elena Genova ◽  
Federica Cavion ◽  
Marianna Lucafò ◽  
Marco Pelin ◽  
Gaetana Lanzi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
In Vitro Study ◽  
Vitro Study ◽  
Primary Immunodeficiencies ◽  
Precision Therapy ◽  
Induced Pluripotent

DEVELOPMENT OF AN IN VITRO STUDY MODEL OF PRKAG2 CARDIOMYOPATHY USING HUMAN INDUCED PLURIPOTENT STEM CELLS

Cytotherapy ◽  
2021 ◽  
Vol 23 (4) ◽  
pp. 9-10
Author(s):  
IPS Bezerra ◽  
MERS Siqueira ◽  
RAQ Barbosa ◽  
EB Sternick ◽  
TH Kasai-Brunswick ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
In Vitro Study ◽  
Vitro Study ◽  
Induced Pluripotent

scholarly journals Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia

2021 ◽  
Vol 22 (9) ◽  
pp. 4334
Author(s):  
Katrina Albert ◽  
Jonna Niskanen ◽  
Sara Kälvälä ◽  
Šárka Lehtonen
Keyword(s):  
Stem Cells ◽  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Induced Pluripotent Stem Cells ◽  
Glial Cells ◽  
Pluripotent Stem Cells ◽  
Cell Types ◽  
Human Ipscs ◽  
Induced Pluripotent

Induced pluripotent stem cells (iPSCs) are a self-renewable pool of cells derived from an organism’s somatic cells. These can then be programmed to other cell types, including neurons. Use of iPSCs in research has been two-fold as they have been used for human disease modelling as well as for the possibility to generate new therapies. Particularly in complex human diseases, such as neurodegenerative diseases, iPSCs can give advantages over traditional animal models in that they more accurately represent the human genome. Additionally, patient-derived cells can be modified using gene editing technology and further transplanted to the brain. Glial cells have recently become important avenues of research in the field of neurodegenerative diseases, for example, in Alzheimer’s disease and Parkinson’s disease. This review focuses on using glial cells (astrocytes, microglia, and oligodendrocytes) derived from human iPSCs in order to give a better understanding of how these cells contribute to neurodegenerative disease pathology. Using glia iPSCs in in vitro cell culture, cerebral organoids, and intracranial transplantation may give us future insight into both more accurate models and disease-modifying therapies.

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