Practical Assessment of Clinical Drug–Drug Interactions in Drug Development Using Physiologically Based Pharmacokinetics Modeling

2019 ◽  
Vol 105 (6) ◽  
pp. 1326-1328 ◽  
Author(s):  
Mohamad Shebley ◽  
Heidi J. Einolf
Keyword(s):  
Drug Development ◽  
Drug Interactions ◽  
Physiologically Based Pharmacokinetics ◽  
Physiologically Based ◽  
Clinical Drug

scholarly journals Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

2015 ◽  
Vol 7 (4) ◽  
pp. 383-391 ◽  
Author(s):  
Hasan Erbil Abaci ◽  
Michael L. Shuler
Keyword(s):  
Drug Development ◽  
Development Studies ◽  
Human Tissues ◽  
Design Strategies ◽  
Physiologically Based Pharmacokinetics ◽  
Microfluidic Platforms ◽  
Chip Design ◽  
Microphysiological Systems ◽  
Physiologically Based

Advances in maintaining multiple human tissues on microfluidic platforms has led to a growing interest in the development of microphysiological systems for drug development studies.

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